Background
The analysis of risk factors for predicting related complications has not
been reported to date.
Objective
This study aims to investigate the risk factors of related complications of
percutaneous transluminal septal myocardial ablation (PTSMA) for
hypertrophic obstructive cardiomyopathy (HOCM) retrospectively.
Method
Clinical data, and one-year follow-up results of patients with HOCM, who
underwent PTSMA between January 2000 and July 2013 in the Department of
Cardiology, Liaoning Province People’s Hospital, Liaoning Province, China,
were retrospectively analyzed to determine risk factors for operative
complications with multiple logistic regression analysis. All p values are
two-sided, with values of p < 0.05 being considered statistically
significant.
Results
Among 319 patients with HOCM, PTSMA was performed in 224 patients (120 males
and 104 females, mean age was 48.20 ± 14.34 years old). The incidence
of PTSMA procedure-related complications was 36.23% (66/224), which included
three cardiac deaths, two cardiac shocks, one ST-segment elevated myocardial
infarction, two ventricular fibrillations, 20 third-degree atrioventricular
(AV) blocks (four patients were implanted with a permanent pacemaker (PPM)),
32 complete right bundle branch blocks, two complete left bundle branch
blocks, and four puncture-related complications. After multivariate logistic
regression analysis, it was found that age, gender, coronary artery
diseases, diabetes, heart rate, cardiac function on admission, the number of
septal ablations, and the volume of alcohol were not independent risk
factors correlated to the whole complications, except for hypertension (OR:
4.856; 95% CI: 1.732-13.609). Early experience appears to be associated with
the occurrence of complications.
Conclusion
Hypertension was an independent risk factor for PTSMA procedure-related
complications. It might be much safer and more efficient if PTSMA procedures
are restricted to experienced centers, according to the analysis results for
the learning curve.