Remote Ischemic Conditioning Enhances Collateral Circulation Through Leptomeningeal Anastomosis and Diminishes Early Ischemic Lesions and Infarct Volume in Middle Cerebral Artery Occlusion

Saito, Misa; Hoshino, Takao; Ishizuka, Kôzô; Iwasaki, S; Toi, Sono; Shibata, Noriyuki; Kitagawa, Kazuo

doi:10.1007/s12975-022-01108-2

Cited by 6 publications

(2 citation statements)

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“…In this study, we further found that previous hypertension history might be associated with poor efficacy of RIC. We speculate that this may be related to pathological vascular remodeling induced by hypertension 33,34 . Long‐term hypertension would reduce cerebral flow reserve and cerebral perfusion and impair cerebral autoregulation 35–38 .…”

Section: Discussionmentioning

confidence: 99%

“…We speculate that this may be related to pathological vascular remodeling induced by hypertension. 33 , 34 Long‐term hypertension would reduce cerebral flow reserve and cerebral perfusion and impair cerebral autoregulation. 35 , 36 , 37 , 38 In patients with hypertension history, the improving effect of RIC on cerebral flow reserve and autoregulation may be discounted greatly because of the deterioration of vasoregulation capacity due to long duration hypertension.…”

Section: Discussionmentioning

confidence: 99%

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Baseline systolic blood pressure, hypertension history, and efficacy of remote ischemic conditioning

Cai,

Zhang,

Cui

et al. 2024

Ann Clin Transl Neurol

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ObjectiveWe performed a post hoc exploratory analysis of Remote Ischemic Conditioning for Acute Moderate Ischemic Stroke (RICAMIS) to determine whether hypertension history and baseline systolic blood pressure (SBP) affect the efficacy of remote ischemic conditioning (RIC).MethodsBased on the full analysis set of RICAMIS, patients were divided into hypertension versus non‐hypertension group, or <140 mmHg versus ≥140 mmHg group. Each group was further subdivided into RIC and control subgroups. The primary outcome was modified Rankin Scale (mRS) 0–1 at 90 days. Efficacy of RIC was compared among patients with hypertension versus nonhypertension history and SBP of <140 mmHg versus ≥140 mmHg. Furthermore, the interaction effect of treatment with hypertension and SBP was assessed.ResultsCompared with control group, RIC produced a significantly higher proportion of patients with excellent functional outcome in the nonhypertension group (RIC vs. control: 65.7% vs. 57.0%, OR 1.45, 95% CI 1.06–1.98; p = 0.02), but no significant difference was observed in the hypertension group (RIC vs. control: 69.1% vs. 65.2%, p = 0.17). Similar results were observed in SBP ≥140 mmHg group (RIC vs. control: 68.0% vs. 61.2%, p = 0.009) and SBP <140 mmHg group (RIC vs. control: 65.6% vs. 64.7%, p = 0.77). No interaction effect of RIC on primary outcome was identified.InterpretationHypertension and baseline SBP did not affect the neuroprotective effect of RIC, but they were associated with higher probability of excellent functional outcome in patients with acute moderate ischemic stroke who received RIC treatment.

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Section: Discussionmentioning

confidence: 99%