Remote Ischemic Preconditioning and Endothelial Function in Patients with Acute Myocardial Infarction and Primary PCI

Sympathetic nervous response to ischemia-reperfusion injury in humans is altered with remote ischemic preconditioning

“…We noted that RHI, an index of endothelial function, was significantly higher following IR in the subjects submitted to RIPC, suggesting improved local endothelial function. This finding is in line with a recent report showing improvement in the endothelial function of patients undergoing ischemic preconditioning before primary percutaneous coronary intervention (22). In the present study, the possibilities to explain the enhanced RHI induced by RIPC may include the protection of the availability of NO (26), the reduced formation of ROS, such as was recently demonstrated in a rat model of mesenteric ischemia (7), or the reduced activation of the sympathetic nervous system activity.…”

“…RIPC may also act by improving endothelial dysfunction and reducing inflammation and reactive oxygen species (ROS) formation (20). Indeed, studies in humans have shown that RIPC can either improve endothelial function (22), or prevent ischemiareperfusion (IR)-induced endothelial dysfunction as well as prevent systemic neutrophil activation (15). Sympathetic nervous activation and norepinephrine overflow is a key component of the IR-induced organ injury (11), and pharmacological sympathoinhibition was found to prevent the ischemic kidney injury in rats (32), thereby indicating the potential deleterious effect of ischemia-induced sympathetic activation.…”

MicroRNA-29a/b/c targets iNOS and is involved in protective remote ischemic preconditioning in an ischemia-reperfusion rat model of non-alcoholic fatty liver disease

“…In recent decades, IR injury has become a topic of particular interest in the context of liver surgery and research. Studies have predominantly focused on RIPC, which is a strategy for harnessing the body's endogenous protective capabilities against the injury that is incurred during IR (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). NO is an essential mediator of the protection that is afforded by hind-limb RIPC against liver IR injury (25).…”

“…Increasing evidence indicates that remote ischemic preconditioning (RIPC) represents a strategy for harnessing the body's endogenous protective capabilities to counter the injury that is incurred by IR in various organs (5)(6)(7)(8)(9)(10)(11)(12)(13), including the normal liver (14)(15)(16)(17). The protective mechanism of RIPC is highly complex (18)(19)(20)(21)(22) and involves the improvement of hepatic oxygenation (23), reduction of serum cytokine-induced neutrophil chemoattractant-1 levels (24), modulation of hepatic microcirculation (15) and activation of the soluble guanylate cyclase-cyclic guanosine monophosphate pathway (20), resulting in protective effects against IR injury.…”

Remote ischemic preconditioning versus intermittent hypoxia training: a comparative analysis for cardioprotection

“…Recent studies of Manchurov and coauthors [64] from Russia demonstrated that RIPC prior to primary percutaneous coronary intervention (PCI) significantly improves endothelial function in patients with acute myocardial infarction and this effect remains constant at least for a week. Forty eight patients with AMI were enrolled.…”