Remote metastases from intracranial tumours.

Abstract

SUMMARY A review of the primary tumours of the nervous system encountered over the past 16 years from the population of the west of Scotland uncovered only three tumours in which remote extracranial metastases had developed. In all three, there had been surgical intervention before the appearance of metastases. The findings in these patients are compared with those in other published accounts of this unusual complication. Primary brain tumours probably account for less than I % of all deaths, and the vast majority of these kill as a result of their intracranial effects, in contrast to most malignant tumours elsewhere in the body which are lethal largely as a result of metastases. However, it is now well recognised that primary intracranial tumours can give rise to extracranial metastases (Drachman et al

Prognostic Factors After Extraneural Metastasis of Medulloblastoma

“…In 1936, Nelson (11) reported the first case of medulloblastoma that had metastasized outside of the CNS. Subsequently, a number of case series or reports of ENM of medulloblastoma have been published (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29). Patients diagnosed with ENM have traditionally been treated with different chemotherapeutic agents including vincristine, cisplatin, carboplatin, and cyclophosphamide (4,30); however, despite treatment, ENM has historically been associated with a poor prognosis (30).…”

Transferral of malignancy as a complication of organ transplantation: an insuperable problem?

“…It is pertinent to note that central nervous system lesions may occasionally metastasise systemically. 23 Secondly, as stated previously by Barnes and Fox,24 the donor must have a full laparotomy during removal of the organ. If the donor is a cadaver a necropsy should automatically follow.…”

Metastasi intraperitoneali da medulloblastoma

“…L'accesso al sistema venoso o linfatico delle cellule tumorali è sicuramente promosso dalla craniotomia 5,13,19,22 , ma può prescindere da questa 16 . Il prolungamento della sopravvivenza dei pazienti e l'affinamento dei mezzi diagnostici contribuisce alla loro sempre maggiore frequenza 8,26 .…”