Remote post-conditioning reduces hypoxic damage early after experimental stroke

Hasseldam, Henrik; Hansen-Schwartz, Jacob; Munkholm, Nina; Hou, Jack

doi:10.1179/1743132812y.0000000130

Cited by 11 publications

(8 citation statements)

References 17 publications

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“…Loukogeorgakis et al demonstrated for the first time in humans that RIPC can be induced by transient limb ischemia and provides protection from the effects of acute ischemic brain injury [25]. Multiple subsequent studies also have shown beneficial neuroprotective effects of RIPC in adult cerebral ischemic models [26], [27], [28]. Zhou et al first applied RIPC in a rat neonatal HI model and showed that rapid RIPC immediately following HI significantly reduced the infarct volume and improved neurologic effects [8].…”

Section: Discussionmentioning

confidence: 99%

Delayed Remote Ischemic Postconditioning Improves Long Term Sensory Motor Deficits in a Neonatal Hypoxic Ischemic Rat Model

Perera

Tang

et al. 2014

PLoS ONE

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ObjectiveRemote Ischemic Postconditioning (RIPC) is a promising therapeutic intervention wherein a sub-lethal ischemic insult induced in one organ (limb) improves ischemia in an organ distant to it (brain). The main objective of this study was to investigate the long-term functional effects of delayed RIPC in a neonatal hypoxia-ischemia (HI) rat model.Method10 day old rat pups were subjected to delayed RIPC treatment and randomized into four groups: 1) Sham, 2) HI induced, 3) HI +24 hr delayed RIPC, and 4) HI +24 hr delayed RIPC with three consecutive daily treatments. Neurobehavioral tests, brain weights, gross and microscopic brain tissue morphologies, and systemic organ weights were evaluated at five weeks post surgery.ResultsHI induced rats performed significantly worse than sham but both groups of delayed RIPC treatment showed improvement of sensory motor functions. Furthermore, compared to the HI induced group, the delayed RIPC treatment groups showed no further detrimental changes on brain tissue, both grossly and morphologically, and no changes on the systemic organ weights.ConclusionDelayed RIPC significantly improves long term sensory motor deficits in a neonatal HI rat model. A 24 hr delayed treatment does not significantly attenuate morphological brain injury but does attenuate sensory motor deficits. Sensory motor deficits improve with both a single treatment and with three consecutive daily treatments, and the consecutive treatments are possibly being more beneficial.

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Section: Discussionmentioning

confidence: 99%

Delayed Remote Ischemic Postconditioning Improves Long Term Sensory Motor Deficits in a Neonatal Hypoxic Ischemic Rat Model

Perera

Tang

et al. 2014

PLoS ONE

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“…There is evidence showing that ischemic/hypoxic conditioning is neuroprotective due to improving CBF in ischemic stroke, likely through reduced reflow vasospasm (Gao et al , 2008a; Hasseldam et al , 2013). Using 14 C iodoantipyrine autoradiography to measure CBF at varied occlusion intervals, a striking recovery of CBF during permanent MCAO in preconditioned spontaneously hypertensive rats was observed, presaging reductions in infarct volume (Zhao and Nowak, 2006).…”

Section: Ischemic/hypoxic Conditioningmentioning

confidence: 99%

Non-pharmaceutical therapies for stroke: Mechanisms and clinical implications

Chen

Luo

et al. 2014

Progress in Neurobiology

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Stroke is deemed a worldwide leading cause of neurological disability and death, however, there is currently no promising pharmacotherapy for acute ischemic stroke aside from intravenous or intra-arterial thrombolysis. Yet because of the narrow therapeutic time window involved, thrombolytic application is very restricted in clinical settings. Accumulating data suggest that non-pharmaceutical therapies for stroke might provide new opportunities for stroke treatment. Here we review recent research progress in the mechanisms and clinical implications of non-pharmaceutical therapies, mainly including neuroprotective approaches such as hypothermia, ischemic/hypoxic conditioning, acupuncture, medical gases, transcranial laser therapy, etc. In addition, we briefly summarize mechanical endovascular recanalization devices and recovery devices for the treatment of the chronic phase of stroke and discuss the relative merits of these devices.

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“…In spite of numerous investigative efforts, finding efficient therapy for the ischemic stroke remains elusive [1,2]. Naturally occurring well-established phenomena of "preconditioning" [3] and "postconditioning" [4] suggest the existence of internal neuroprotective mechanisms [5]. Recruitment of internal neuroprotective mechanisms provides attractive alternative for the existing methods [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Forehead Stimulation Decreases Volume of the Infarction Triggered by Permanent Occlusion of Middle Cerebral Artery in Rats

Shiflett¹,

Parent²,

Golanov³

2015

JNSK

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Background: Universally present in animals diving response triggered by stimulation of the trigeminal nerve is known as "oxygen conserving reflex". This powerful integrative response includes apnea, bradycardia, and blood flow redistribution targeted to protect the brain against hypoxia. We hypothesized that diving response triggered by forehead stimulation can be neuroprotective in rat. Methods:Male Sprague-Dawley rats were anesthetized, intubated, and artificially ventilated while blood gases and body temperature were maintained at physiologic levels. Arterial pressure, heart rate and temperature and in some cases, CBF were monitored. The forehead skin selectively was continuously selectively cooled or electrically stimulated for one hour. Middle cerebral artery was permanently occluded and infarction volume was determined 24 hours later.Results: Forehead cooling to +11 °C decreased infarction volume by 31% compared to control (58±14 mm 3 vs. 87±12 mm 3 , corrected for edema, p<0.05). Electrical stimulation of the forehead decreased infarction volume by 65% (30±7 mm 3 vs. 81±10 mm 3 corrected for edema, p<0.01) while temporal muscle temperature remained unchanged. Blood gases, body temperatures were comparable in all groups. Forehead cooling alone triggered changes in arterial pressure and cerebral blood flow comparable to changes observed during diving response in rats. Conclusion:Stimulation, temperature or electrical, of the forehead in rats decreases volume of the infarction produced by permanent occlusion of middle cerebral artery. Diving response may have neuroprotective component, and its activation can be beneficial for brain protection. Submit Manuscript | http://medcraveonline.com J Neurol Stroke 2015, 2(5): 00067We hypothesize that activation of the facial areas innervated by the first branch of the trigeminal nerve may have neuroprotective effect. Here we demonstrate that stimulation of the forehead in rats, area innervated by the trigeminal nerve [26], effectively decreases volume of the brain infarction triggered by permanent middle cerebral artery occlusion (MCAO).

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Remote post-conditioning reduces hypoxic damage early after experimental stroke

Cited by 11 publications

References 17 publications

Delayed Remote Ischemic Postconditioning Improves Long Term Sensory Motor Deficits in a Neonatal Hypoxic Ischemic Rat Model

Delayed Remote Ischemic Postconditioning Improves Long Term Sensory Motor Deficits in a Neonatal Hypoxic Ischemic Rat Model

Non-pharmaceutical therapies for stroke: Mechanisms and clinical implications

Forehead Stimulation Decreases Volume of the Infarction Triggered by Permanent Occlusion of Middle Cerebral Artery in Rats

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