Remote Postconditioning Induced by Trauma Protects the Mouse Heart against Ischemia Reperfusion Injury. Involvement of the Neural Pathway and Molecular Mechanisms

Song, Yang; Shan, Jufang; Xue, Ziyi; Wang, S. Y.; Xu, Hui; Liu, Y.; Guo, Yueping; Ren, Xiaoping

doi:10.1007/s10557-016-6661-6

Cited by 6 publications

(13 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More specifically, the models have been limited to young, male mice. There has been no evidence offered that RIC is effective in aged rodents and only some evidence of its effectiveness is seen in females ( 49 , 59 , 78 ). Actually, in clinical studies, RIC would be used to treat aged persons and persons with comorbidities, such as hypertension, diabetes, and dyslipidemia.…”

Section: Discussionmentioning

confidence: 99%

Limb Remote Ischemic Conditioning: Mechanisms, Anesthetics, and the Potential for Expanding Therapeutic Options

et al. 2018

View full text Add to dashboard Cite

Novel and innovative approaches are essential in developing new treatments and improving clinical outcomes in patients with ischemic stroke. Remote ischemic conditioning (RIC) is a series of mechanical interruptions in blood flow of a distal organ, following end organ reperfusion, shown to significantly reduce infarct size through inhibition of oxidation and inflammation. Ischemia/reperfusion (I/R) is what ultimately leads to the irreversible brain damage and clinical picture seen in stroke patients. There have been several reports and reviews about the potential of RIC in acute ischemic stroke; however, the focus here is a comprehensive look at the differences in the three types of RIC (remote pre-, per-, and postconditioning). There are some limited uses of preconditioning in acute ischemic stroke due to the unpredictability of the ischemic event; however, it does provide the identification of biomarkers for clinical studies. Remote limb per- and postconditioning offer a more promising treatment during patient care as they can be harnessed during or after the initial ischemic insult. Though further research is needed, it is imperative to discuss the importance of preclinical data in understanding the methods and mechanisms involved in RIC. This understanding will facilitate translation to a clinically feasible paradigm for use in the hospital setting.

show abstract

Section: Discussionmentioning

confidence: 99%

Limb Remote Ischemic Conditioning: Mechanisms, Anesthetics, and the Potential for Expanding Therapeutic Options

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Furthermore, the concept of RPC confirmed that D r a f t interorgan communication may afford protection against I/R not only in the heart but also in the spinal cord, brain, liver, intestine or kidney (Haapanen et al 2016;Hausenloy and Yellon 2008). Moreover, RPC has been shown to be evoked by numerous other stimuli, such as surgical trauma (Song et al 2016), peripheral nerve stimulation (Reddington et al 2012) or by local release of autacoids (Schulz et al 1998 as depicted in Fig. 1.…”

Section: Introductionmentioning

confidence: 83%

“…The triggering stimulus can originate not only from local I/R, but also from peripheral nociception associated with surgical incision (Jones et al 2009), local surgical trauma (Song et al 2016), local activation of sensory fibers by capsaicin or electrical nerve stimulation (Redington et al 2012).…”

Section: Triggering Mechanisms and Pathways From Remote Organ To Targmentioning

confidence: 99%

Noninvasive approach to mend the broken heart: Is “remote conditioning” a promising strategy for application in humans?

Ravíngerová

Farkasova

Griecsova

et al. 2017

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

Currently, there are no satisfactory interventions to protect the heart against the detrimental effects of ischemia-reperfusion injury. Although ischemic preconditioning (PC) is the most powerful form of intrinsic cardioprotection, its application in humans is limited to planned interventions, due to its short duration and technical requirements. However, many organs/tissues are capable of producing "remote" PC (RPC) when subjected to brief bouts of ischemia-reperfusion. RPC was first described in the heart where brief ischemia in one territory led to protection in other area. Later on, RPC started to be used in patients with acute myocardial infarction, albeit with ambiguous results. It is hypothesized that the connection between the signal triggered in remote organ and protection induced in the heart can be mediated by humoral and neural pathways, as well as via systemic response to short sublethal ischemia. However, although RPC has a potentially important clinical role, our understanding of the mechanistic pathways linking the local stimulus to the remote organ remains incomplete. Nevertheless, RPC appears as a cost-effective and easily performed intervention. Elucidation of protective mechanisms activated in the remote organ may have therapeutic and diagnostic implications in the management of myocardial ischemia and lead to development of pharmacological RPC mimetics.

show abstract

“…However, it has been demonstrated that beta-blockers reduce infarct size in STEMI patients undergoing PCI [ 61 ], and this group of drugs is currently included in the guidelines for the management of these patients [ 60 ]. It has been shown that beta-adrenoreceptors are involved in the mechanisms of myocardial infarct-limiting effect of remote pre- and postconditioning of trauma [ 128 , 129 ]. The existence of some common, inherent mechanisms, such as the activation of C sensory fibers and the K(ATP) channels for both remote preconditioning of trauma [ 65 ] and RIPre/RIPer [ 5 , 83 , 117 ], may be an argument to suggest that sympathetic beta-adrenergic activation is involved in the mechanisms of RIC cardioprotection.…”

Section: Unresolved Questions and Discrepancies On The Mechanisms Of mentioning

confidence: 99%

Neural mechanisms in remote ischaemic conditioning in the heart and brain: mechanistic and translational aspects

et al. 2018

View full text Add to dashboard Cite

Remote ischaemic conditioning (RIC) is a promising method of cardioprotection, with numerous clinical studies having demonstrated its ability to reduce myocardial infarct size and improve prognosis. On the other hand, there are several clinical trials, in particular those conducted in the setting of elective cardiac surgery, that have failed to show any benefit of RIC. These contradictory data indicate that there is insufficient understanding of the mechanisms underlying RIC. RIC is now known to signal indiscriminately, protecting not only the heart, but also other organs. In particular, experimental studies have demonstrated that it is able to reduce infarct size in an acute ischaemic stroke model. However, the mechanisms underlying RIC-induced neuroprotection are even less well understood than for cardioprotection. The existence of bidirectional feedback interactions between the heart and the brain suggests that the mechanisms of RIC-induced neuroprotection and cardioprotection should be studied as a whole. This review, therefore, addresses the topic of the neural component of the RIC mechanism.

show abstract

Remote Postconditioning Induced by Trauma Protects the Mouse Heart against Ischemia Reperfusion Injury. Involvement of the Neural Pathway and Molecular Mechanisms

Cited by 6 publications

References 44 publications

Limb Remote Ischemic Conditioning: Mechanisms, Anesthetics, and the Potential for Expanding Therapeutic Options

Limb Remote Ischemic Conditioning: Mechanisms, Anesthetics, and the Potential for Expanding Therapeutic Options

Noninvasive approach to mend the broken heart: Is “remote conditioning” a promising strategy for application in humans?

Neural mechanisms in remote ischaemic conditioning in the heart and brain: mechanistic and translational aspects

Contact Info

Product

Resources

About