Remote Postconditioning is More Potent than Classic Postconditioning in Reducing the Infarct Size in Anesthetized Rabbits

Gritsopoulos, G.; Iliodromitis, E K; Ζώγα, Αναστασία; Farmakis, Dimitrios; Demerouti, Eftychia; Papalois, Αpostolos; Paraskevaidis, Ioannis; Kremastinos, Dimitrios Th.

doi:10.1007/s10557-009-6168-5

Cited by 57 publications

(42 citation statements)

References 21 publications

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“…Of note, uremic animals treated with RIPC fared no better than their shamoperated counterparts. It is interesting to compare these results with those of Gritsopoulos et al, 38 who found that remote postconditioning was a more potent cytoprotective strategy than classic postconditioning, suggesting that further direct interference with the dependent vascular bed, which had experienced the index ischemic episode, was not entirely without consequence.…”

Section: Discussionmentioning

confidence: 68%

Ischemic Conditioning Protects the Uremic Heart in a Rodent Model of Myocardial Infarction

et al. 2012

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Background— Outcomes after acute myocardial infarction in patients with chronic kidney disease are extremely poor. Ischemic conditioning techniques are among the most powerful cytoprotective strategies discovered to date. However, experimental data suggest that comorbidity may attenuate the protective effects of ischemic conditioning. Methods and Results— We conducted investigations into the effects of chronic uremia on myocardial infarct size and the protective effects of ischemic preconditioning (IPC), remote ischemic preconditioning, and ischemic postconditioning in 2 rodent models of chronic uremia. In addition, a limited investigation into the signaling mechanisms involved in cardioprotection after IPC was performed in both uremic and nonuremic animals. Myocardial infarct size was increased in uremic animals, but all 3 conditioning strategies (IPC, remote IPC, ischemic postconditioning) proved highly efficacious in reducing myocardial infarct size (relative reduction, 86%, 39%, and 65% [ P <0.005, P <0.05, and P <0.05], respectively). Moreover, some protocols (IPC and ischemic postconditioning) appeared to be more effective in uremic than in sham (nonuremic) animals. Analysis of the signaling mechanisms revealed that components of both the reperfusion injury salvage kinase and survivor activating factor enhancement pathways were similarly upregulated in both uremic and nonuremic animals after an IPC stimulus. Conclusion— Conditioning strategies may present the best opportunity to improve outcomes for patients with chronic kidney disease after an acute coronary syndrome.

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Section: Discussionmentioning

confidence: 68%

Ischemic Conditioning Protects the Uremic Heart in a Rodent Model of Myocardial Infarction

et al. 2012

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“…Furthermore, the remote ischemic conditioning procedure can be applied before and during sustained ischemia 76 and at the onset of reperfusion. 77 An experimental study showed that the infarct-size-limiting effects 78 It remains unclear how remote ischemic conditioning exerts cardioprotection; however, 2 major hypotheses have been proposed (Figure 3). The neural hypothesis states that autacoids released from the ischemic remote organ affect the local afferent neural pathway, which in turn, activates the efferent neural pathways to trigger endorgan protection.…”

Section: Remote Ischemic Conditioningmentioning

confidence: 99%

Cardioprotection From Ischemia/Reperfusion Injury

Minamino

2012

Circ J

106

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“…7 Clinically, postconditioning is achieved by repeated inflation and deflation of the angioplasty balloon after emergency coronary intervention. 8 It is now known that postconditioning can be induced experimentally and in humans, remotely, using a transient limb ischemia stimulus identical to that of remote pre-and preconditioning, and in a recent study, remote postconditioning was more effective than local postconditioning in experimental MI 9 . We have shown that repeated daily remote conditioning by limb ischemia leads to significant downregulation of neutrophil activation and proinflammatory responses in humans.…”

mentioning

confidence: 99%

Repeated Remote Ischemic Postconditioning Protects Against Adverse Left Ventricular Remodeling and Improves Survival in a Rat Model of Myocardial Infarction

Wang

Xin²,

Li³

et al. 2011

Circulation Research

159

124

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Rationale: Remote ischemic conditioning induced by repeated episodes of transient limb ischemia is a clinicallyapplicable method for protecting the heart against injury at the time of reperfusion.Objective: To assess the effect of chronic, repeated, remote conditioning on infarct size and long-term remodeling after myocardial infarction. Methods and Results: Rats with ischemia/reperfusion injury received different protocols of remote limbconditioning. While a single early episode of remote ischemic conditioning during coronary occlusion (perconditioning) resulted in a decrease in infarct size on both day 4 and day 28, when it was repeated (postconditioning) intermittently (every 3 days) and intensively (every day), it was not associated with a further decrease in infarct size. However, the protection against adverse remodeling offered by a single episode of limb perconditioning was further enhanced by repeated remote postconditioning therapy in a dose-dependent manner. In separate experiments there was a dose-dependent improvement in survival at 84 days by Kaplan-Meier analysis. Conclusions:

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Remote Postconditioning is More Potent than Classic Postconditioning in Reducing the Infarct Size in Anesthetized Rabbits

Abstract: Remote postconditioning consisted of 1 min isc/1 min rep protects the ischemic rabbit heart in vivo, independently of the site of the remote artery. This intervention seems to confer a stronger protection than the classic postconditioning.

Cited by 57 publications

References 21 publications

Ischemic Conditioning Protects the Uremic Heart in a Rodent Model of Myocardial Infarction

Ischemic Conditioning Protects the Uremic Heart in a Rodent Model of Myocardial Infarction

Cardioprotection From Ischemia/Reperfusion Injury

Repeated Remote Ischemic Postconditioning Protects Against Adverse Left Ventricular Remodeling and Improves Survival in a Rat Model of Myocardial Infarction

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