Remote Preconditioning and Vascular Surgery

Healy, Donagh; Walsh, Stewart R.

doi:10.1177/1074248417702892

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…32 Both events are performed to build ischemia tolerance for few hours/days. 32,39 Our adoptive transfer data used ischemic-trained monocytes isolated 2 or even 7 days after the ischemia insult had ended. Herein, we are evaluating a effect of ischemia training that perpetuates at least for a week and can have a long-term effect on the hindlimb ischemia scenario.…”

Section: Discussionmentioning

confidence: 99%

Ischemic-Trained Monocytes Improve Arteriogenesis in a Mouse Model of Hindlimb Ischemia

Falero-Díaz

Barboza

Pires

et al. 2022

ATVB

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Objective: Monocytes, which play an important role in arteriogenesis, can build immunologic memory by a functional reprogramming that modifies their response to a second challenge. This process, called trained immunity, is evoked by insults that shift monocyte metabolism, increasing HIF (hypoxia-inducible factor)-1α levels. Since ischemia enhances HIF-1α, we evaluate whether ischemia can lead to a functional reprogramming of monocytes, which would contribute to arteriogenesis after hindlimb ischemia. Methods and Results: Mice exposed to ischemia by 24 hours of femoral artery occlusion (24 hours trained) or sham were subjected to hindlimb ischemia one week later; the 24-hour trained mice showed significant improvement in blood flow recovery and arteriogenesis after hindlimb ischemia. Adoptive transfer using bone marrow-derived monocytes (BM-Mono) from 24-hour trained or sham donor mice, demonstrated that recipients subjected to hindlimb ischemia who received 24 hours ischemic-trained monocytes had remarkable blood flow recovery and arteriogenesis. Further, ischemic-trained BM-Mono had increased HIF-1α and GLUT-1 gene expression during femoral artery occlusion. Circulating cytokines and GLUT-1 were also upregulated during femoral artery occlusion.Transcriptomic analysis and confirmatory qPCR performed in 24 hours trained and sham BM-Mono revealed that among the 15 top differentially expressed genes, 4 were involved in lipid metabolism in the ischemic-trained monocytes. Lipidomic analysis confirmed that ischemia training altered the cholesterol metabolism of these monocytes. Further, several histone-modifying epigenetic enzymes measured by qPCR were altered in mouse BM-Mono exposed to 24 hours hypoxia. Conclusions: Ischemia training in BM-Mono leads to a unique gene profile and improves blood flow and arteriogenesis after hindlimb ischemia.

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Section: Discussionmentioning

confidence: 99%

Ischemic-Trained Monocytes Improve Arteriogenesis in a Mouse Model of Hindlimb Ischemia

Falero-Díaz

Barboza

Pires

et al. 2022

ATVB

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“…There have been preclinical 2 , 3 as well as clinical 4 studies showing the effectiveness of RIPC in preventing heart injury from ischemia reperfusion (IR) injury. The clinical application of RIPC has been translated in protecting hearts from IR injury in patients undergoing cardiac surgeries 5 , 6 . However, the precise mechanisms involved in RIPC-induced cardioprotection are not fully explored.…”

Section: Introductionmentioning

confidence: 99%

Remote ischemic preconditioning-induced late cardioprotection: possible role of melatonin-mitoKATP-H2S signaling pathway

Zhang

Jin

2023

Acta Cir. Bras.

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Purpose: Remote ischemic preconditioning (RIPC) confers cardioprotection against ischemia reperfusion (IR) injury. However, the precise mechanisms involved in RIPC-induced cardioprotection are not fully explored. The present study was aimed to identify the role of melatonin in RIPC-induced late cardioprotective effects in rats and to explore the role of H 2 S, TNF-α and mitoK ATP in melatonin-mediated effects in RIPC. Methods: Wistar rats were subjected to RIPC in which hind limb was subjected to four alternate cycles of ischemia and reperfusion of 5 min duration by using a neonatal blood pressure cuff. After 24 h of RIPC or ramelteon-induced pharmacological preconditioning, hearts were isolated and subjected to IR injury on the Langendorff apparatus. Results: RIPC and ramelteon preconditioning protected the hearts from IR injury and it was assessed by a decrease in LDH-1, cTnT and increase in left ventricular developed pressure (LVDP). RIPC increased the melatonin levels (in plasma), H 2 S (in heart) and decreased TNF-α levels. The effects of RIPC were abolished in the presence of melatonin receptor blocker (luzindole), ganglionic blocker (hexamethonium) and mitochondrial K ATP blocker (5-hydroxydecanoic acid). Conclusions: RIPC produce delayed cardioprotection against IR injury through the activation of neuronal pathway, which may increase the plasma melatonin levels to activate the cardioprotective signaling pathway involving the opening of mitochondrial K ATP channels, decrease in TNF-α production and increase in H 2 S levels. Ramelteon-induced pharmacological preconditioning may also activate the cardioprotective signaling pathway involving the opening of mitochondrial K ATP channels, decrease in TNF-α production and increase in H 2 S levels.

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“…12 Evaluation of RIC has not been limited to cardiac surgery and, moreover, has not been limited to heart 13 ∓15 : The scope of RIC includes (but is not limited to) cardioprotection in the settings of acute myocardial infarction and elective percutaneous coronary intervention, better maintenance of renal function in acute kidney injury and kidney transplant, as well as organ protection in patients undergoing vascular surgery—facets of RIC that are all addressed by leaders in their respective fields. 16 ∓20 In addition, an intriguing hypothesis is presented to suggest that the salutary effects of RIC may extend beyond organ protection: RIC may serve as a novel strategy to maintain uterine quiescence during pregnancy and thus limit the incidence (and potentially devastating consequences) of preterm birth. 21 Part II of the focused issue, scheduled for publication in September 2017, expands on novel aspects of RIC to include evidence that local and remote conditioning have a favorable, inhibitory effect on platelet-mediated thrombosis, that exercise may serve as a RIC-like stimulus and initiate a cardioprotective phenotype, and, interestingly, that RIC may enhance exercise performance.…”

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confidence: 99%