Drinking water shortage is a major concern in villages across southern Jiangxi, and this has impacted economic and social development. In order to address this challenge, groundwater prospecting was carried out in the villages under the support of Drinking Water Safety Project of China Geological Survey. In this study, we present two example sites in Ningdu County selected to demonstrate the combined hydrogeological survey, and the direct current electrical resistivity method was utilized for the present study for groundwater exploration in karst-granite distribution areas. First, a hydrogeological study was effectively used to delineate shallow severely weathered structural fissures as prospective target water-bearing beds. Then, a direct current electrical resistivity survey was used to confirm the distribution, thickness scale, and water-bearing features. The structural fractured zone whose distribution and trend were first established through hydrogeological surveys and whose development characteristics and water-richness were investigated by the direct current electrical resistivity method is the target layer for water exploration in the karst-granite rock areas. The water-bearing fracture zone shows a groove or strip-shape low resistivity anomaly and can be identified in its aquifer position according to its IP half decay time (Th), apparent polarizability (ηs), and apparent resistivity (ρs). The findings demonstrate that the above methods were successful in locating water potential areas, providing information for comparison and accurate borehole positioning. The results of the subsequent drilling and pumping tests supported the interpretation of the geophysical exploration data, and the water output from both boreholes met the objectives of this study. This groundwater search might serve as a guide for future exploration projects in similar areas.