In recent years, remote sensing has become an indispensable supplementary method for determining water depth in the seaports. At present, many scholars use multi-spectral satellite data to invert the water depth of the seaports, but how to select the appropriate satellite data in the seaports area is worth exploring. In this article, the differences in the retrieving ability between domestic and foreign multispectral images are compared, through building the random forest model and the band ratio model, which use different multispectral images to conduct retrieving water depth in Nanshan Port in conjunction with the WBMS multi-beam sounding system. The band ratio model and random forest model are chosen for water depth exploration, remote sensing images use GF-6, GF-2, Sentinel-2B, and Landsat 8 OLI data, which are all popular and easily accessible. The final experiment results from the constant adjustment of the model parameter show that the domestic series of GF-6 images performed the best in this experiment. The Root Mean Square Error (RMSE) and Mean Relative Error (MRE) of the random forest model are only 1.202 and 0.187, respectively. Simultaneously, it is discovered that the ‘Red Edge’ band of GF-6 is also very helpful in improving the accuracy of water depth inversion, which is rarely mentioned in previous studies. To some extent, the preceding studies demonstrate that it is possible to investigate water depth using common multispectral remote sensing images. In the case of some bathymetry inversion models or in some waters, the aforementioned study demonstrates that it is possible to examine the water depth using domestic remote sensing images that are superior to foreign multispectral images in terms of bathymetry inversion ability.