Remote Triggering of Waves in an Electrochemical System

Christoph, Johannes; Strasser, Peter; Eiswirth, M.; Ertl, G.

doi:10.1126/science.284.5412.291

Cited by 63 publications

(39 citation statements)

References 8 publications

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“…Bistability produces local amplification of the spreading signal, and the combination of local amplification and diffusion may generate traveling waves. In fact, traveling waves in bistable systems have been extensively studied in physics, chemistry and biology (Castiglione et al, 2002;Christoph et al, 1999;Keener and Sneyd, 1998;Shvartsman et al, 2002;Zhabotinsky and Zaikin, 1973). MAPK cascades and the PI3K/PDK1/Akt cascade coupled with the PIP3 synthesis pathway might be candidates for bistable protein kinase cascades that are capable of propagating traveling waves.…”

Section: Traveling Waves Of Activated Protein Kinasesmentioning

confidence: 99%

Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors

Kholodenko

2003

Journal of Experimental Biology

150

122

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SUMMARYExtracellular signals received by membrane receptors are processed, encoded and transferred to the nucleus via phosphorylation and spatial relocation of protein members of multiple component pathways, such as mitogen activated protein kinase (MAPK) cascades. The receptor-induced membrane recruitment of the cytoplasmic protein SOS results in the activation of the Ras/MAPK cascade. It has been suggested that the membrane recruitment of signaling proteins causes an increase in the diffusion-limited rates. We have recently shown that this increase is too small to be responsible for enhanced signal transduction. Instead we demonstrate that the function of membrane localization is to increase the number (or average lifetime) of complexes between signaling partners. A hallmark of signaling pathways is the spatial separation of activation and deactivation mechanisms; e.g. a protein can be phosphorylated at the cell surface by a membrane-bound kinase and dephosphorylated in the cytosol by a cytosolic phosphatase. Given the measured values of protein diffusion coefficients and of phosphatase and kinase activities, the spatial separation is shown to result in precipitous phospho-protein gradients. When information transfer is hampered by slow protein diffusion and rapid dephosphorylation, phospho-protein trafficking within endocytic vesicles may be an efficient way to deliver messages to physiologically relevant locations. The proposed mechanism explains recent observations that various inhibitors of endocytosis can inhibit MAPK activation. Additional mechanisms facilitating the relay of signals from cell-surface receptors to the nucleus can involve the assembly of protein kinases on a scaffolding protein and active transport of signaling complexes by molecular motors. We also discuss long-range signaling within a cell, such as survival signaling in neurons. We hypothesize that ligand-independent waves of receptor activation or/and traveling waves of phosphorylated kinases emerge to spread the signals over long distances.

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Section: Traveling Waves Of Activated Protein Kinasesmentioning

confidence: 99%

Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors

Kholodenko

2003

Journal of Experimental Biology

150

122

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“…[4][5][6] The patterns arise through the interaction of nonlinear reaction and coupling among the reacting sites. Coupling can occur through the potential field and/or transport of chemical species.…”

Section: Introductionmentioning

confidence: 99%

Phase synchronization of nonidentical chaotic electrochemical oscillators

Kiss

Hudson

2002

Phys. Chem. Chem. Phys.

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Experiments on two coupled chaotic electrochemical oscillators with different frequencies are presented. We consider two types of coupling. The first is imposed through a set of external resistors. The second arises from the potential drop in the electrolyte and generally depends on cell geometry and reaction rate. Phase synchronization is observed with the addition of weak coupling of both types. Along with the onset of phase synchronization an increase in the amplitude of the mean current oscillations occurs. Simulations using a coupled form of an electrochemical model support the experimental findings.

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“…10 In many standard electrochemical applications, the setup creates strong, long-range coupling through the electrolyte, which hampers the formation of pronounced spatial patterns. For the case of weak, long-range coupling, however, complex spatiotemporal oscillations [11][12][13][14] as well as accelerating 15 and "remote-triggered" fronts 16 have been observed. Short-range or local coupling can be achieved by establishing an equipotential surface (e.g., the counter electrode) or similar boundary conditions in close distance to the working electrode.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Waves on Patterned Surfaces: Propagation through Narrow Gaps and Channels

2001

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The dissolution and corrosion of iron and certain types of steel can involve the propagation of electrochemical waves. Low-carbon steel plates covered by nitric acid solutions self-organize pseudo-two-dimensional wave patterns which share many features with reaction-diffusion waves in excitable systems. Here, we investigate the dynamics of these electrodissolution waves in the presence of geometrical constraints. A simple procedure for the preparation of insulating, millimeter-scale obstacles is presented, which allows the controlled, local protection of the metal surface. This method is used in the measurement of the material consumption rate per wave [(850 ( 50) nm/wave or 6-7 g/(m 2 wave)] as well as for the study of front propagation through narrow gaps and long channels. In channels, the wave velocity decreases with decreasing width from 10 to 4 mm/s. Propagation failures occur within the channel if its width is smaller than 0.2-0.4 mm. These results indicate that the obstacles have sink-like boundaries. For the estimation of the critical nucleation size in this system, we prepared short and narrow gaps that induce wave blockage for openings smaller than 0.65 ( 0.1 mm.

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Remote Triggering of Waves in an Electrochemical System

Cited by 63 publications

References 8 publications

Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors

Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors

Phase synchronization of nonidentical chaotic electrochemical oscillators

Electrochemical Waves on Patterned Surfaces: Propagation through Narrow Gaps and Channels

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