Remotely nano-rupturable yolk/shell capsules for magnetically-triggered drug release

Hu, Shang Hsiu; Liu, Ta Chung; Tung, Tsan Hua; LIu, Dean-Mo; Chen, San‐Yuan

doi:10.1039/c0cc03998e

Cited by 51 publications

(38 citation statements)

References 20 publications

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Section: Therapymentioning

confidence: 96%

“…Here, silica layer acted as an effective barrier to prevent unexpected passive diffusion of drug molecules and enhance the efficiency of site-specific release (Fig. 11a) [170]. Without the assistance of polymer, the inorganic core/shell structural combination of magnetic nanoclusters and layered double hydroxides (LDH) was also applied as a drug delivery vehicle, and magnetically controlled release of doxifluridine was in good response to the simulation of external magnetic field [171].…”

Section: Therapymentioning

confidence: 98%

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Biogenic and biomimetic magnetic nanosized assemblies

Dong

Zhang

et al. 2012

Nano Today

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Section: Therapymentioning

confidence: 96%

Section: Therapymentioning

confidence: 98%

Biogenic and biomimetic magnetic nanosized assemblies

Dong

Zhang

et al. 2012

Nano Today

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“…For instance, Hu et al fabricated core/shell particles containing an IONP core and a thermally responsive polymer shell into which hydrophobic drugs were encapsulated [142]. …”

Section: Engineering Of Nanoparticles For Tumor Detectionmentioning

confidence: 99%

Nanoparticles for improving cancer diagnosis

Chen

Zhen

Todd

et al. 2013

Materials Science and Engineering: R: Reports

105

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Despite the progress in developing new therapeutic modalities, cancer remains one of the leading diseases causing human mortality. This is mainly attributed to the inability to diagnose tumors in their early stage. By the time the tumor is confirmed, the cancer may have already metastasized, thereby making therapies challenging or even impossible. It is therefore crucial to develop new or to improve existing diagnostic tools to enable diagnosis of cancer in its early or even pre-syndrome stage. The emergence of nanotechnology has provided such a possibility. Unique physical and physiochemical properties allow nanoparticles to be utilized as tags with excellent sensitivity. When coupled with the appropriate targeting molecules, nanoparticle-based probes can interact with a biological system and sense biological changes on the molecular level with unprecedented accuracy. In the past several years, much progress has been made in applying nanotechnology to clinical imaging and diagnostics, and interdisciplinary efforts have made an impact on clinical cancer management. This article aims to review the progress in this exciting area with emphases on the preparation and engineering techniques that have been developed to assemble “smart” nanoprobes.

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“…[17][18] One such area of focus has centered on encapsulated polymeric particulate systems; with conceptual designs demonstrated in bi-layer, multi-layered and several other complex systems. [19][20][21] Among all polymeric particulate formats with compartmentalized (interior) structures, yolkshell particles (YSPs) appear least explored although they display unique features and physical properties; including low densities, large surface areas and excellent loading capacities.…”

Section: Introductionmentioning

confidence: 99%

Tri-Needle Coaxial Electrospray Engineering of Magnetic Polymer Yolk–Shell Particles Possessing Dual-Imaging Modality, Multiagent Compartments, and Trigger Release Potential

Zhang¹,

Yao²,

Ding³

et al. 2017

ACS Appl. Mater. Interfaces

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ABSTRACT:Particulate platforms capable of delivering multiple actives while providing diagnostic features have gained considerable interest over the last few years. In this study, magnetic polymer yolkshell particles (YSPs) were engineered using a tri-needle coaxial electrospraying technique enabling dual-mode (ultrasonic and magnetic resonance) imaging capability with specific multidrug compartments via an advanced single-step encapsulation process. YSPs comprised magnetic Fe 3 O 4 nanoparticles (MNPs) embedded in the polymeric shell, an interfacing oil layer and a polymeric core (i.e. composite shell-oil interface-polymeric core). Ultrasound backscatter signal frequency was modulated through YSP loading dosage, and both T 1 and T 2 weighted MRI signal intensities were shown to reduce with increasing MNP content (YSP outer shell). Three fluorescent dyes (selected as model probes with varying hydrophobicities) were co-encapsulated separately to confirm YSP structure. Probe release profiles were tuned by varying power or frequency of an external auxillary magnetic field (AMF, 0.7 mT (LAMF) or 1.4 mT (HAMF)).In addition, an "inversion" phenomenon for AMF-enhanced drug release process was captured and is reported. Low YSP cytotoxicity (5mg/ml) and biocompatibility (murine, L929) was confirmed. In summary, magnetic YSPs demonstrate timely potential as multifunctional theranostic agents for dual-imaging modality and magnetically controlled co-active delivery.

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Remotely nano-rupturable yolk/shell capsules for magnetically-triggered drug release

Cited by 51 publications

References 20 publications

Biogenic and biomimetic magnetic nanosized assemblies

Biogenic and biomimetic magnetic nanosized assemblies

Nanoparticles for improving cancer diagnosis

Tri-Needle Coaxial Electrospray Engineering of Magnetic Polymer Yolk–Shell Particles Possessing Dual-Imaging Modality, Multiagent Compartments, and Trigger Release Potential

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