Endocrine-disrupting chemicals are a new class of pollutants that can affect hormonal metabolic processes in animals and humans. They can enter the aquatic environment through various pathways and gradually become enriched, thus posing a serious threat to the endocrine and physiological systems of both animals and humans. Nano zero-valent iron has promising applications in endocrine disruptor removal due to its excellent reducing properties and high specific surface area. However, given the dispersed focus and fragmented results of current studies, a comprehensive review is still lacking. In this paper, it was analyzed that the types of endocrine disruptors and their emission pathways reveal the sources of these compounds. Then, the main technologies currently used for endocrine disruptor treatment are introduced, covering physical, chemical, and biological treatment methods, with a special focus on persulfate oxidation among advanced oxidation technologies. Also, the paper summarizes the various activation methods of persulfate oxidation technology and proposes the nZVI-activated persulfate technology as the most promising means of treatment. In addition, this paper reviews the research progress of different modification methods of nZVI in activating persulfate for the removal of EDCs. Finally, the discussion includes recycling studies of nZVI/PS technology and emphasizes the urgency and importance of endocrine disruptor treatment. The review of this paper provides further scientific basis and technical support for nZVI/PS technology in the field of endocrine disruptor management.