Removal of annexin V–positive sperm cells for intracytoplasmic sperm injection in ovum donation cycles does not improve reproductive outcome: a controlled and randomized trial in unselected males

Romany, L.; Garrido, Nicolás; Motato, Y.; Aparicio, Belén; Remohı́, José; Meseguer, Marcos

doi:10.1016/j.fertnstert.2014.09.001

Cited by 73 publications

(65 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results revealed similar results for the parameters studied when MACS was applied and in the control group (in which only swim up was performed) [12]. Once the efficiency of sperm selection by MACS has been evaluated, it should be further validated by confirming the safety of the technique through analyzing obstetric and perinatal outcomes of the babies conceived following transfer of embryos done from ICSI with MACS in order to compare these outcomes with those observed in pregnancies and live births achieved in ICSI conducted with swim up only.…”

Section: Introductionsupporting

confidence: 82%

“…The results revealed similar results for all the parameters studied in the experimental group (MACS) and among controls (in which only swim up was performed) [12].…”

Section: Discussionsupporting

confidence: 65%

“…Semen specimens from the control group (n = 125) were prepared by swim up, as previously described [14]. Samples from the study group (n = 138) were prepared by swim up followed by MACS and incubation with AVconjugated microbeads (MB) in order to remove AV+ sperm cells [12]. All the cycles were performed according to ICSI procedures [15].…”

Section: Ivf Proceduresmentioning

confidence: 99%

“…The main IVF parameters recorded have been described previously by Romany et al 2014 [12] and constituted the first report of the finalized RCT. The main pregnancy outcome measures were gestational hypertension, preterm birth, and other pregnancy-related complications.…”

Section: Data Source and Outcome Measurementsmentioning

confidence: 99%

“…Male characteristics and sperm parameters (concentration, motility, and morphology) have been described in a previous manuscript [12].…”

Section: Baseline Characteristics Of the Study Populationmentioning

confidence: 99%

See 4 more Smart Citations

Obstetric and perinatal outcome of babies born from sperm selected by MACS from a randomized controlled trial

Romany

Garrido

Cobo

et al. 2016

J Assist Reprod Genet

Self Cite

View full text Add to dashboard Cite

Purpose The purpose of this study is to assess outcomes after magnetic-activated cell sorting (MACS) technology on obstetric and perinatal outcomes compared with those achieved after swim up from randomized controlled trial. Methods This is a two-arm, unicentric, prospective, randomized, and triple-blinded trial and has a total of 237 infertile couples, between October 2010 and January 2013. A total of 65 and 66 newborns from MACS and control group, respectively, were described. Results MACS had no clinically relevant adverse effects on obstetric and perinatal outcomes. No differences were found for obstetric problems including premature rupture of membranes 6.1% (CI95% 0-12.8) vs. 5.9% (CI95% 0-12.4), 1st trimester bleeding 28.6% (CI95% 15.9-41.2) vs. 23.5% (CI95% 11.9-35.1), invasive procedures as amniocentesis 2.0% (CI95% 0-5.9) vs. 3.9% (CI95% 0-9.2), diabetes 14.3% (CI95% 4.5-24.1) vs. 9.8% (CI95% 1.6-17.9), anemia 6.1% (CI95% 0-12.8) vs. 5.9%(CI95% 0-12.4), 2nd and 3rd trimesters 10.2% (CI95% 1.7-18.7) vs. 5.9% (CI95% 0-12.4), urinary tract infection 8.2% (CI95% 0.5-15.9) vs. 3.9% (CI95% 0-9.2), pregnancy-induced hypertension 6.1% (CI95% 0-12.8) vs. 15.7% (CI95% 5.7-25.7), birth weight (g) 2684.10 (CI95% 2499.48-2868.72) vs. 2676.12 (CI95% 2499.02-2852.21), neonatal height (cm) 48.3 (CI95% 47.1-49.4) vs. 46.5 (CI95% 44.6-48.4), and gestational cholestasis 0%(CI95% 0-0) vs. 3.9% (CI95% 0-9.2), respectively, in MACS group compared with control group. Conclusions Our data suggest that MACS technology does not increase or decrease Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation adverse obstetric and perinatal outcomes in children conceived when this technology was performed, being the largest randomized control trial with live birth reported results with MACS.

show abstract

Section: Introductionsupporting

confidence: 82%

“…The results revealed similar results for all the parameters studied in the experimental group (MACS) and among controls (in which only swim up was performed) [12].…”

Section: Discussionsupporting

confidence: 65%