Removal of cockroach allergen from inner-city homes

Eggleston, Peyton A.; Wood, Robert A.; Rańd, Cynthia S.; Nixon, W.J.; Chen, Pei Hua; Lukk, Peter

doi:10.1016/s0091-6749(99)70296-4

Cited by 97 publications

(57 citation statements)

References 9 publications

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“…The homes in this study were all cockroach infested row homes and low-rise apartments with adjacent units not involved in the intervention. These homes are similar to those found in other urban areas11 , 12 , [14][15][16] , although they may not be representative of cockroach infested homes in high-rise apartment buildings.…”

Section: Discussionsupporting

confidence: 60%

Cockroach allergen reduction by cockroach control alone in low-income urban homes: A randomized control trial

Sever¹,

Arbes²,

Gore³

et al. 2007

Journal of Allergy and Clinical Immunology

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Section: Discussionsupporting

confidence: 60%

Cockroach allergen reduction by cockroach control alone in low-income urban homes: A randomized control trial

Sever¹,

Arbes²,

Gore³

et al. 2007

Journal of Allergy and Clinical Immunology

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“…15 Settled dust samples were collected by vacuum (DataVac, Metropolitan Vacuum Cleaner Corp, Suffern, NY) from the child_s bed and bedroom floor using an unwoven fabric sleeve inserted into the nozzle. 4 The mattress, bedding, and a 1-m 2 area near and underneath the bed were vacuumed for 2 minutes. An aqueous extract of sieved dust (sieve size 300 mm) was prepared in PBS-Tween (1:20 weight/ volume).…”

Section: Study Populationmentioning

confidence: 99%

“…2 The reasons for this disparity are complex and include unhealthy home environ-ments. [3][4][5] Home environmental surveys in the inner city have documented that homes are frequently old and in poor repair, with leaky roofs, water damage, and mold contamination. In addition, cigarette smoking rates are high, cockroach and rodent infestation is common, 3,[5][6][7][8] and indoor NO 2 and particulate levels have been reported to be high.…”

Section: Introductionmentioning

confidence: 99%

Indoor Environmental Differences between Inner City and Suburban Homes of Children with Asthma

et al. 2007

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We conducted this study to compare environmental exposures in suburban homes of children with asthma to exposures in inner city homes of children with asthma, to better understand important differences of indoor pollutant exposure that might contribute to increased asthma morbidity in the inner city. Indoor PM 10 , PM 2.5 , NO 2 , O 3 , and airborne and dust allergen levels were measured in the homes of 120 children with asthma, 100 living in inner city Baltimore and 20 living in the surrounding counties. Home conditions and health outcome measures were also compared. The inner city and suburban homes differed in ways that might affect airborne environmental exposures. The inner city homes had more cigarette smoking (67% vs. 5%, pG.001), signs of disrepair (77% vs. 5%, pG.001), and cockroach (64% vs. 0%, pG.001) and mouse (80% vs. 5%, pG.001) infestation. The inner city homes had higher geometric mean (GM) levels (pG.001) of PM 10 (47 vs. 18 mg/m 3 ), PM 2.5 (34 vs. 8.7 mg/m 3 ), NO 2 [19 ppb vs. below detection (BD)], and O 3 (1.9 vs. .015 ppb) than suburban homes. The inner city homes had lower GM bedroom dust allergen levels of dust mite (.29 vs. 1.2 mg/g, p=.022), dog (.38 vs. 5.5 mg/g, pG.001) and cat (.75 vs. 2.4 mg/g, p=.039), but higher levels of mouse (3.2 vs. .013 mg/g, pG.001) and cockroach (4.5 vs. .42 U/g, pG.001). The inner city homes also had higher GM airborne mouse allergen levels (.055 vs. .016 ng/m 3 , p=.002). Compared with the homes of suburban children with asthma, the homes of inner city Baltimore children with asthma had higher levels of airborne pollutants and home characteristics that predispose to greater asthma morbidity.

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“…In particular, low-income and minority children have the highest morbidity and mortality rates for asthma in the United States (1). A number of studies have shown that environmental allergen exposure, particularly that of the cockroach, is the major contributing factor for asthma exacerbations among inner-city children (2)(3)(4).…”

mentioning

confidence: 99%

Eotaxin Represents the Principal Eosinophil Chemoattractant in a Novel Murine Asthma Model Induced by House Dust Containing Cockroach Allergens

Kim

Merry

Nemzek

et al. 2001

The Journal of Immunology

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Asthma represents a serious health problem particularly for inner city children, and recent studies have identified that cockroach allergens trigger many of these asthmatic attacks. This study tested the concept that asthma-like pulmonary inflammation may be induced by house dust containing cockroach allergens. An aqueous extract was prepared from a house dust sample containing endotoxin and high levels of cockroach allergens. BALB/c mice were immunized with the house dust extract (HDE) and received two additional pulmonary challenges. Bronchoalveolar lavage (BAL) eosinophil counts and eotaxin levels were significantly increased in immunized mice exposed to the HDE, whereas neutrophils were the predominant BAL inflammatory cell in the unimmunized mice. Kinetics studies in immunized mice demonstrated a peak pulmonary inflammatory response 48 h after the last challenge. The allergic response in this model was further confirmed by histological and physiological studies demonstrating a significant influx of eosinophils and lymphocytes in the peribronchial area, and severe airway hyperreactivity through whole-body plethysmography. The specificity of the response was established by immunizing with HDE and challenging with purified cockroach allergen, which induced pulmonary eosinophilia and airway hyperreactivity. Ab inhibition of eotaxin significantly inhibited the number of BAL eosinophils. These data describe a novel murine model of asthma-like pulmonary inflammation induced by house dust containing endotoxin and cockroach allergens and further demonstrate that eotaxin represents the principal chemoattractant for the recruitment of the pulmonary eosinophils.

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Removal of cockroach allergen from inner-city homes

Cited by 97 publications

References 9 publications

Cockroach allergen reduction by cockroach control alone in low-income urban homes: A randomized control trial

Cockroach allergen reduction by cockroach control alone in low-income urban homes: A randomized control trial

Indoor Environmental Differences between Inner City and Suburban Homes of Children with Asthma

Eotaxin Represents the Principal Eosinophil Chemoattractant in a Novel Murine Asthma Model Induced by House Dust Containing Cockroach Allergens

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