Removal of Cr(VI) from aqueous solutions using EDCC-MCM-41: Isotherm, kinetics and thermodynamic evaluation

Shah, Bhavna A.; Patel, Akash D; Bagia, Maryam I.; Oluyinka, Olutayo A.

doi:10.1080/01932691.2018.1544081

Cited by 7 publications

(4 citation statements)

References 47 publications

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“…In the BET curves, type IV International Union of Pure and Applied Chemistry (IUPAC) isotherms were observed for all nanoformulations [29]. These isotherms are distinctive to MSNs [30], thus indicating that MCM and FBZ-MCM nanoparticles, such as MSNs-based particles, were successfully synthesized. The BET surface area for FBZ-MCM nanoparticles was 112 m 2 /g, which is less than that of MCM nanoparticles (264 m 2 /g).…”

Section: Brunauer-emmett-teller (Bet) Surface Area Analysismentioning

confidence: 85%

β-Lactoglobulin-Modified Mesoporous Silica Nanoparticles: A Promising Carrier for the Targeted Delivery of Fenbendazole into Prostate Cancer Cells

et al. 2022

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The clinical utilization of fenbendazole (FBZ) as a potential anticancer drug has been limited due to its low water solubility, which causes its low bioavailability. The development of a drug nanoformulation that includes the solubilizing agent as a drug carrier can improve solubility and bioavailability. In this study, Mobil Composition of Matter Number 48 (MCM-48) nanoparticles were synthesized and functionalized with succinylated β-lactoglobulin (BLG) to prevent early-burst drug release. The BLG-modified amine-functionalized MCM-48 (MCM-BLG) nanoparticles were loaded with FBZ to produce the drug nanoformulation (FBZ-MCM-BLG) and improved the water solubility and, consequently, its anticancer effects against human prostate cancer PC-3 cells. The prepared FBZ-MCM-BLG was characterized in terms of size, zeta potential, drug loading capacity, morphology, thermal and chemical analyses, drug release, cellular uptake, cell viability, cell proliferation, production of reactive oxygen species (ROS), and cell migration. The results demonstrated that the FBZ-MCM-BLG nanoparticles have a spherical morphology with a size and zeta potential of 369 ± 28 nm and 28 ± 0.4 mV, respectively. The drug loading efficiency of the new nanoformulation was 19%. The release of FBZ was pH-dependent; a maximum cumulative release of about 76 and 62% in 12 h and a burst release of 53 and 38% in the first 0.5 h was observed at pH 1.2 and 6.8, respectively. The prepared FBZ-MCM-BLG formulation demonstrated higher cytotoxicity effects against PC-3 cells by 5.6- and 1.8-fold, respectively, when compared to FBZ and FBZ-MCM nanoparticles. The new formulation also increased the production of ROS by 1.6- and 1.2-fold and inhibited the migration of PC-3 cells when compared to the FBZ and FBZ-MCM nanoparticles, respectively. Overall, FBZ-MCM-BLG nanoparticles improved FBZ delivery to PC-3 cells and have the potential to be evaluated for the treatment of prostate cancer following a comprehensive in vivo study.

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Section: Brunauer-emmett-teller (Bet) Surface Area Analysismentioning

confidence: 85%

β-Lactoglobulin-Modified Mesoporous Silica Nanoparticles: A Promising Carrier for the Targeted Delivery of Fenbendazole into Prostate Cancer Cells

et al. 2022

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“…N 2 -BET was used to measure the pore size, volume, and surface area of the NPs. Both MCM and MCM-FBZ NPs demonstrated type IV International Union of Pure and Applied Chemistry (IUPAC) isotherms, which are characteristic of MSNPs [ 32 ]. Three distinct stages were observed in the MCM isotherm, containing two steps at P/P 0 = 0.29 and P/P 0 = 0.34 ( Figure 2 C).…”

Section: Resultsmentioning

confidence: 99%

“…Increasing the relative pressure caused an abrupt increase in the amount of N 2 adsorption due to the capillary condensation within the uniform pores. The third stage in the adsorption isotherm occurred at 0.33 < P/P 0 < 0.98 owing to multilayer N 2 adsorption on the external surface of MCM NPs [ 32 ]. In addition, the average pore volume of MCM NPs was larger than that of MCM-FBZ NPs (1.10 versus 0.53 cm 3 /g·nm) ( Figure 2 D).…”

Section: Resultsmentioning

confidence: 99%

PEGylated Mesoporous Silica Nanoparticles (MCM-41): A Promising Carrier for the Targeted Delivery of Fenbendazole into Prostrate Cancer Cells

et al. 2021

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Low water solubility and thus low bioavailability limit the clinical application of fenbendazole (FBZ) as a potential anticancer drug. Solubilizing agents, such as Mobil Composition of Matter Number 41 (MCM) as a drug carrier, can improve the water solubility of drugs. In this study, PEGylated MCM (PEG-MCM) nanoparticles (NPs) were synthesized and loaded with FBZ (PEG-MCM-FBZ) to improve its solubility and, as a result, its cytotoxicity effect against human prostate cancer PC-3 cells. The loading efficiency of FBZ onto PEG-MCM NPs was 17.2%. The size and zeta potential of PEG-MCM-FBZ NPs were 366.3 ± 6.9 nm and 24.7 ± 0.4 mV, respectively. They had a spherical shape and released the drug in a controlled manner at pH 1.2 and pH 6.2. PEG-MCM-FBZ were found to inhibit the migration of PC-3 cells, increase the cytotoxicity effects of FBZ against PC-3 cells by 3.8-fold, and were more potent by 1.4-fold, when compared to the non-PEGylated NPs. In addition, PEG-MCM-FBZ promoted the production of reactive oxygen species by 1.3- and 1.2-fold, respectively, when compared to FBZ and MCM-FBZ. Overall, the results demonstrate that PEG-MCM-FBZ NPs enhanced FBZ delivery to PC-3 cells; therefore, they have the potential to treat prostate cancer after a comprehensive in vivo study.

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“…9,27-31 Some surface modication includes decorating MCM-41 with amino ligands, EDCC ligand, graing of TiO 2 with MCM-41, impregnation of CuO on ZrO-MCM-41 for the reduction of Cr(VI) to less toxic Cr(III) etc. [32][33][34][35] Very few reports are available regarding the adsorption of Cr(VI) using metal ion complex. 36 We report here Fe(III) chelated MCM-41-AEAPTMS for the abstraction of Cr(VI).…”

Section: Introductionmentioning

confidence: 99%

Efficient removal of chromate ions from aqueous solution using a highly cost-effective ferric coordinated [3-(2-aminoethylamino)propyl]trimethoxysilane–MCM-41 adsorbent

2021

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Removal of Cr(VI) from aqueous solutions using EDCC-MCM-41: Isotherm, kinetics and thermodynamic evaluation

Cited by 7 publications

References 47 publications

β-Lactoglobulin-Modified Mesoporous Silica Nanoparticles: A Promising Carrier for the Targeted Delivery of Fenbendazole into Prostate Cancer Cells

β-Lactoglobulin-Modified Mesoporous Silica Nanoparticles: A Promising Carrier for the Targeted Delivery of Fenbendazole into Prostate Cancer Cells

PEGylated Mesoporous Silica Nanoparticles (MCM-41): A Promising Carrier for the Targeted Delivery of Fenbendazole into Prostrate Cancer Cells

Efficient removal of chromate ions from aqueous solution using a highly cost-effective ferric coordinated [3-(2-aminoethylamino)propyl]trimethoxysilane–MCM-41 adsorbent

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