Removal of endobronchial mucormycosis lesion through a rigid bronchoscope.

Al-Majed, Sulaiman; Al-Kassimi, Feisal A.; Ashour, Mahmoud; Mekki, M.; Sadiq, Sobia

doi:10.1136/thx.47.3.203

Cited by 13 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In patients with EB disease, radiographic findings are usually nonspecific and can vary from focal consolidation to mass effect [62, 67, 116]. Specific radiological signs of infarction, or cavitary lesions including air crescent sign, have seldom been reported.…”

Section: Discussionmentioning

confidence: 99%

“…As it is an angioinvasive organism, infarction is its hallmark and hemoptysis is a common clinical symptom as well as cause of death. If EB involvement occurs, it mainly affects large bronchi and is also associated with high mortality [62, 67]. Patients with EB disease mainly present with dyspnea and hemoptysis; the latter can sometimes be massive due to angioinvasion leading to bronchoarterial fistulas (n = 6, 19%).…”

Section: Discussionmentioning

confidence: 99%

“…Consistent with this, the most common underlying condition was diabetes mellitus (n = 20, 65%) in EB mucormycosis. Hematologic malignancies, prolonged neutropenia, treatment with corticosteroids or deferoxamine, bronchogenic cancer, renal transplantation and acquired immunodeficiency syndrome were other reported risk factors [6,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73]. Consistent with this, 7 patients (23%) were reported to be immunocompromised hosts; including diabetic patients, the number increased to 25 (81%), reflecting the opportunistic behavior of this organism.…”

Section: Discussionmentioning

confidence: 99%

“…Reviewing the English literature, we recognized that the most common agents causing EBFI are Aspergillus spp. [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45], Coccidioides immitis [46] , agents of zygomycosis [6,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73], Candida spp. [6, 34,74,75,76], Cryptococcus neoformans [77,78,79,80,81,82,83,84,85,86,87,88], and Histoplasma capsulatum [89,…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Endobronchial Fungal Disease: An Under-Recognized Entity

Karnak

Avery²,

Gildea

et al. 2006

Respiration

View full text Add to dashboard Cite

Most fungi enter the human body via inhalation; however, endobronchial fungal infection (EBFI) seems to be a rare manifestation compared to pulmonary or systemic disease. This presentation seems to be related to environmental factors as well as to the host status. With the increasing popularity of flexible bronchoscopy, it is being recognized with a higher frequency. Bronchoscopic findings in EBFI vary from mild mucosal inflammation to central airway obstruction. We searched English literature related to the topic and found 228 total cases of EBFI: Aspergillus species (121), Coccidioides immitis (38), Zygomycetes (31), Candida species (14) Cryptococcus neoformans (13), and Histoplasma capsulatum (11). We have also included a single case of endobronchial Pseudallescheria boydii infection in a lung transplant recipient that has not been reported previously. Most patients were immunocompromised, exhibited systemic manifestations of the primary infection, and responded to appropriate therapy. EBFI should be included in the differential diagnosis of any form of airway lesions in immunocompromised patients, especially among residents from the endemic areas.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Endobronchial Fungal Disease: An Under-Recognized Entity

Karnak

Avery²,

Gildea

et al. 2006

Respiration

View full text Add to dashboard Cite

show abstract

“…Mucor and Rhizopus are the most commonly reported pathogens of mucormycosis. The endoscopic appearance most commonly seen are mucoid plugs, yellowish or whitish in color, endobronchial mass or polypoid lesions, white cheese like masses, plaques, and areas of necrosis (18,46,59,(74)(75)(76)(77)(78). In patients with airway cryptococcal infections, the bronchoscopic appearance has been reported as whitish or yellowish masses, mucous plugs, red or white thrush-like plaques, mucosal granularity, white granulation tissue, elevated ulcerated lesions, and polypoid masses ( Figure 2) (6,44,64,(79)(80)(81).…”

Section: Bronchoscopic Findings In Fungal Caoimentioning

confidence: 99%

Infections causing central airway obstruction: role of bronchoscopy in diagnosis and management

Keshishyan¹,

DeLorenzo²,

Hammoud³

et al. 2017

J. Thorac. Dis.

View full text Add to dashboard Cite

Central airway obstructive infections (CAOI) are challenging medical conditions that may represent an advanced and complicated process of ongoing infections. The epidemiology of CAOI is unknown as well as the pathophysiology and the mechanism of development. This is due to sparse data in the literature that consists mainly of case reports and retrospective case series. CAOI can be caused by fungal, bacterial, parasitic and viral infections. Most patients with CAOI can be diagnosed clinically and with chest imaging, which demonstrate obstruction of the central airways. However, bronchoscopy is commonly used to confirm and obtain a specific diagnosis to guide specific therapy. In recent years, interventional pulmonology (IP) is becoming widely available and offer a minimally invasive approach for the management of central airway diseases such as cancers, benign strictures, and other conditions. Various bronchoscopic modalities are used to treat central airway obstruction (CAO), such as mechanical debulking, endobronchial laser therapy, electrocautery, argon plasma coagulation, cryotherapy, and airway stenting. In patients with CAOI, the role of therapeutic bronchoscopy is not clearly defined, but many isolated reports in the literature described bronchoscopic intervention in combination with medical therapy as the initial management approach. In this paper, we present cases of CAOI that underwent bronchoscopic intervention as part of their management. We described the infectious etiology, locations, bronchoscopic findings and bronchoscopic modalities for airway management.

show abstract

Pulmonary Mucormycosis

Lee

Mossad²,

Adal³

1999

Arch Intern Med

330

125

View full text Add to dashboard Cite

Pulmonary mucormycosis is relatively uncommon but an important opportunistic fungal infection in immunocompromised persons. The literature on the subject is sparse. We describe a recent case and review the literature to delineate the clinical characteristics of this infection. We searched the MEDLINE database for articles published in the English-language literature since 1970 and carefully analyzed 87 cases. The main risk factors were diabetes mellitus, hematologic cancers, renal insufficiency, and organ transplantation. Several patients had no apparent immune compromise. There was a predilection for involvement of the upper lobes. Air crescent signs on chest x-ray films were predictors of pulmonary hemorrhage and death from hemoptysis. Fiberoptic bronchoscopy was a useful diagnostic method, and histopathologic examination was more sensitive than fungal cultures. The overall survival rate was 44%. Patients treated with a combined medical-surgical approach had a better outcome than patients who did not undergo surgery. Thus, this relatively rare but often fatal disease should be suspected in immunocompromised patients who fail to respond to antibacterial therapy. Early recognition and aggressive management are warranted to maximize chances for cure. Optimal therapy requires systemic antifungal therapy, surgical resection, and, when possible, control of the patient's underlying disease.

show abstract

Removal of endobronchial mucormycosis lesion through a rigid bronchoscope.

Cited by 13 publications

References 9 publications

Endobronchial Fungal Disease: An Under-Recognized Entity

Endobronchial Fungal Disease: An Under-Recognized Entity

Infections causing central airway obstruction: role of bronchoscopy in diagnosis and management

Pulmonary Mucormycosis

Contact Info

Product

Resources

About