Removal of Leukocytes from Whole Blood and Erythrocyte Suspensions by Filtration through Cotton Wool

Diepenhorst, P; Sprokholt, R.; Hk, Prins

doi:10.1111/j.1423-0410.1972.tb03465.x

Cited by 117 publications

(6 citation statements)

References 7 publications

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“…It was found that most of the phenomena observed during leukocyte filtration experiments could be explained by a general mathematical formulation of the process [Eqs. (8) and (9)]. Simplification of this theory, by neglecting the explicit effects of cell-cell interaction in the filter on the filter efficiency, allowed a quantitative description of the filtration process.…”

Section: Discussionmentioning

confidence: 99%

“…To describe the results of filtration experiments by means of the general mathematical formulation for the filtration process [Eqs. (8) and (9)], at least three filtration parameters, c, urnax and A, , should be solved independently. Since theoretical relations for these parameters in terms of the properties of the filter are not yet well developed, this can only be achieved by trial and error.…”

Section: Curve Fitting Experimentsmentioning

confidence: 99%

“…Recently, Prins and Steneke? 8 have developed a computer model to explain the depletion of leukocytes in filters composed of filter segments with different leukocyte trapping efficiencies. With the use of this model, they were able to simulate a number of different filtration experiments.…”

Section: Introductionmentioning

confidence: 99%

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A mathematical model for the leukocyte filtration process

Bruil¹,

Beugeling²,

Feijén³

1995

Biotech & Bioengineering

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Leukocyte filters are applied clinically to remove leukocytes from blood. In order to optimize leukocyte filters, a mathematical model to describe the leukocyte filtration process was developed by modification of a general theoretical model for depth filtration. The model presented here can be used to predict the time-dependent leukocyte filtration as a function of cell-cell interaction in the filter, filter efficiency, filter capacity, filter dimensions, and leukocyte concentration in the suspension applied to the filter. The results of different leukocyte filtration experiments previously reported in the literature could be well described by the present model. 0 1995 John Wiley & Sons, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Curve Fitting Experimentsmentioning

confidence: 99%

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A mathematical model for the leukocyte filtration process

Bruil¹,

Beugeling²,

Feijén³

1995

Biotech & Bioengineering

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“…Additive components include citrate (binds calcium to hinder clotting), 4 phosphate (reduces cellular loss of phosphate necessary to maintain adenosine triphosphate [ATP] levels), 5,6 glucose/dextrose (energy source), saline (osmotic agent) and mannitol (free radical scavenger and membrane stabilizer). They can increase RBC storage life from 2 weeks 7 to 5 weeks 8 . But the effect that replacing plasma with such additive solutions has on RBC response to crystalloid exposure is unknown.…”

Section: Introductionmentioning

confidence: 99%

Mixing commonly used crystalloid solutions with red blood cells in five common additives does not negatively impact hemolysis, aggregometry, or deformability

Yarnoff

Dodd‐o

2020

Transfusion

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Background: Literature is beginning to challenge the belief that it is unsafe to coinfuse red blood cells (RBCs) with solutions other than isotonic saline. We recently showed that additive-free RBCs tolerated coincubation with Plasma-Lyte or catecholamines dissolved in normal saline (NS), though 5% dextrose in water (D5W) promoted hemolysis. Herein, we evaluate the effect of coincubating crystalloids on additive-preserved RBC hemolysis, aggregation, and membrane deformability. Study Design and Methods: RBCs were coincubated 5 minutes with plasma, NS, Plasma-Lyte, lactated Ringer's (LR) or D5W (1 mL PRBC +131.3 μL solution). Samples were then assessed for hemolysis (free hemoglobin), aggregation (critical shear stress [mPa]), and membrane deformability (elongation index [EI]). Significance (P ≤ .05) by t test or ANOVA with post-hoc Tukey-Kramer test. Results: Additive-prepared RBCs coincubated with crystalloid instead of plasma demonstrated: (a) no increase in hemolysis as indicated by plasma free hemoglobin levels that is likely to be clinically relevant; (b) no increase, but in some cases a decrease, in aggregation as indicated by critical shear stress; and (c) in some combinations, a deterioration in deformability. When present, the deformability decrease was likely clinically insignificant in degree, and always returned to normal when the crystalloid was subsequently diluted out with plasma. Conclusion: Our data suggest that additive-prepared RBCs coincubated for 5 minutes with any of four common crystalloids demonstrate no clinically relevant increased lysis, increased aggregation, or decreased deformability.

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“…Cotton wool fibers were first used as the filter material to remove leucocytes from blood [6]. Subsequently, different synthetic material fibers were developed for the leucocyte filtration technique, which includes cellulose acetate [7], polyethylene terephthalate (PET) [5], polyurethane [8], polybutylene terephthalate [9,10], polypropylene (PP) [11], polyethylene vinyl alcohol (EVAL) [12], etc.…”

Section: Introductionmentioning

confidence: 99%

Application of 4T-PET fibers/nonwovens for leucocyte filters

Huang

Lin

et al. 2018

Journal of Industrial Textiles

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Polyethylene terephthalate (PET) fiber with four T-lobe cross section (4T-fiber) has been applied to textile products due to the structural characteristic of micro-grooved channels to provide the high wicking, warming, and elastic properties. In this study, nonwoven (NW) filters composed of one layer of 4T-PET NW (containing 65% 4T-fibers) with one, three, or five layers of polypropylene (PP) NW (4T-PET NW + PP NW × 1, 3, or 5) were proposed for blood filtration to remove leucocytes to reduce blood transfusion-related adverse reactions. The removal rate of leucocytes could be enhanced when the PP NW layers were increased. The presence of the 4T-PET NW on the surface of five layers of PP NW (4T-PET NW + PP NW × 5) filters resulted in a higher erythrocyte recovery rate without losing the capability to remove leucocytes and platelets. Based on the theoretical analysis, leucodepletion filters were further prepared by stacking four 4T-PET NW + PP NW × 5 units together. The optimum filtration results of the filters for filtrating 110 mL of red blood cell concentrates could be prepared when four units of 4T-PET NW + PP × 5 NW placed in a series combination.

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Removal of Leukocytes from Whole Blood and Erythrocyte Suspensions by Filtration through Cotton Wool

Cited by 117 publications

References 7 publications

A mathematical model for the leukocyte filtration process

A mathematical model for the leukocyte filtration process

Mixing commonly used crystalloid solutions with red blood cells in five common additives does not negatively impact hemolysis, aggregometry, or deformability

Application of 4T-PET fibers/nonwovens for leucocyte filters

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