Removal of miconazole from water by O3, UV/H2O2 and electrochemical advanced oxidation: Real-time process monitoring and degradation pathway elucidation

Souza, Allisson Barros de; Mielcke, J.; Ali, Izba; Dewil, Raf; Goor, Tom van de; Cabooter, Deirdre

doi:10.1016/j.jece.2023.109993

Cited by 17 publications

(3 citation statements)

References 57 publications

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“…The rearrangement of the structure likely occurred due to the presence of the free amine group, which served as an electron donor to the carbon atom in the benzene ring after the detachment of the chlorine atom. The formation of this product in degradation studies was also reported by de Souza et al [18].…”

Section: Metabolite Identification and Transformation Pathwaysupporting

confidence: 79%

“…Drawing from the insights provided by Rietjens et al, who presented a hypothesis for predicting the regioselectivity of the cytochrome P450 hydroxylation of halogenated benzenes, we can infer that in the case of M3, hydroxylation occurred at the C4 position of the benzene ring, while in the case of M4, hydroxylation took place in the meta position relative to the chloro substituents [22]. De Souza et al have previously identified a product in which hydroxylation took place in the benzene ring of miconazole [18]. However, this was not a miconazole metabolism product, but a transformation product formed during the ozonation and electro-oxidation of miconazole.…”

Section: Metabolite Identification and Transformation Pathwaymentioning

confidence: 88%

“…For instance, the E-peroxone process, utilizing a Pt anode and carbon-PTFE cathode at 15 • C, demonstrated superior efficacy in miconazole elimination, achieving faster results compared to conventional ozonation [17]. De Souza et al also concluded that miconazole under optimal conditions exhibits high degradability, with 98% removal achieved within 5 min of ozonation and 94% removal achieved after 180 min of electrochemical oxidation on a boron-doped diamond anode with an applied current of 10 mA [18]. The study identified eight transformation products resulting from electrochemical oxidation and twelve products arising from ozonation.…”

Section: Introductionmentioning

confidence: 99%

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Identification of New Hepatic Metabolites of Miconazole by Biological and Electrochemical Methods Using Ultra-High-Performance Liquid Chromatography Combined with High-Resolution Mass Spectrometry

Wroński,

Trawiński,

Skibiński

2024

Molecules

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The main objective of this study was to investigate the metabolism of miconazole, an azole antifungal drug. Miconazole was subjected to incubation with human liver microsomes (HLM) to mimic phase I metabolism reactions for the first time. Employing a combination of an HLM assay and UHPLC-HRMS analysis enabled the identification of seven metabolites of miconazole, undescribed so far. Throughout the incubation with HLM, miconazole underwent biotransformation reactions including hydroxylation of the benzene ring and oxidation of the imidazole moiety, along with its subsequent degradation. Additionally, based on the obtained results, screen-printed electrodes (SPEs) were optimized to simulate the same biotransformation reactions, by the use of a simple, fast, and cheap electrochemical method. The potential toxicity of the identified metabolites was assessed using various in silico models.

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Section: Metabolite Identification and Transformation Pathwaysupporting

confidence: 79%

Section: Metabolite Identification and Transformation Pathwaymentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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Identification of New Hepatic Metabolites of Miconazole by Biological and Electrochemical Methods Using Ultra-High-Performance Liquid Chromatography Combined with High-Resolution Mass Spectrometry

Wroński,

Trawiński,

Skibiński

2024

Molecules

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Degradation of the Antibiotic Sulfamethoxazole by Ozonation: A Comprehensive Review

Martini,

Ighalo,

Emenike

et al. 2024

CleanMat

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Sulfamethoxazole (SMX) is an antibiotic widely used for the treatment of several diseases, especially respiratory and urinary. Due to its widespread use, its presence in the environment has been on the rise. This study discusses the degradation of the antibiotic SMX through the ozonation process. SMX is preferentially degraded by the direct action of O3 on the molecule, starting by breaking the double bonds in the aromatic ring. Through ozonation it is possible to obtain complete SMX degradation within 10 min, but the mineralization of the solution is not achieved, reaching total organic carbon removal efficiencies of 5%–60%, depending on the reaction time. Factors such as the presence of organic matter (OM) and the pH of the solution interfere with the degradation of SMX. The OM acts as a radical scavenger, decreasing the efficiency of degradation, while the pH interferes with the decomposition of O3 into radicals and the dissolution of the oxidant in the medium, in addition to influencing the state of ionization of the SMX making it more or less prone to reactions. In general, most other remediation processes are carried out on a laboratory scale. To increase the level of these processes to a full scale, more pilot‐scale studies are needed. In addition, it is necessary to focus on the practice of reusing materials, avoiding the generation of secondary pollution, and increasing the useful life of the material. The review also discusses the reaction mechanisms, intermediate compounds formed, mineralization of the solution, and factors that influence the process, which can help in making decisions for future studies to be carried out in the area. Prospects in the research area revolve around using metal–organic frameworks as molecular imprinting technology to modify heterogeneous catalysts, integration of external energy, bimetallic systems, and evaluation of deactivation mechanisms.

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Removal of Staphylococcus aureus using electro-fenton, UV/H2O2, and combination of electro-fenton and UV/H2O2 processes; optimization of operational parameters

Dokhani,

kheirkhah,

Kalantar-Neyestanaki

et al. 2024

Appl Water Sci

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Staphylococcus aureus (S. aureus) is an opportunistic pathogen of the gram-positive variety, known to cause a range of severe infections including cellulitis, pneumonia, osteomyelitis, endocarditis, and sepsis. These infections are associated with significant morbidity and mortality rates in both hospital and community settings. Therefore, it is important to remove S. aureus from the aqueous solution. The present study employed response surface methodology as an effective strategy to optimize the removal of S. aureus through the electro-Fenton (EF), UV/H2O2, and combination EF-UV/H2O2 processes. Under the optimized conditions, the maximum removal efficiency in the EF process of 48.5%, UV/H2O2 process of 36.2%, and combination EF-UV/H2O2 process of 100%. The optimum condition for removal efficiency using combination EF-UV/H2O2 process of 100% was attained at S. aureus concentration of 5 × 106 CFU mL−1, current density of 8.0 mA cm−2, H2O2 dosage of 170 µL L−1, and 2 lamps UV during 7.0 min. Both the production of •OH in the EF and UV/H2O2 process and the additive oxidation effect of UV/H2O2 are the main reasons for the better performance of combination EF-UV/H2O2 process. The results indicate that the EF-UV/H2O2 process is highly promising and environmentally sustainable method for treating wastewater samples contaminated with S. aureus.

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Removal of miconazole from water by O3, UV/H2O2 and electrochemical advanced oxidation: Real-time process monitoring and degradation pathway elucidation

Cited by 17 publications

References 57 publications

Identification of New Hepatic Metabolites of Miconazole by Biological and Electrochemical Methods Using Ultra-High-Performance Liquid Chromatography Combined with High-Resolution Mass Spectrometry

Identification of New Hepatic Metabolites of Miconazole by Biological and Electrochemical Methods Using Ultra-High-Performance Liquid Chromatography Combined with High-Resolution Mass Spectrometry

Degradation of the Antibiotic Sulfamethoxazole by Ozonation: A Comprehensive Review

Removal of Staphylococcus aureus using electro-fenton, UV/H2O2, and combination of electro-fenton and UV/H2O2 processes; optimization of operational parameters

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