Removal of soluble biologic response modifiers (complement and chemokines) by a bedside white cell‐reduction filter

El, Snyder; Mechanic, S.; Baril, Laurence; Davenport, R. D.

doi:10.1046/j.1537-2995.1996.36896374374.x

Cited by 29 publications

(22 citation statements)

References 40 publications

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“…Moreover, it has been shown that some biofilter materials can absorb complement split products as well as other inflammatory mediators, e.g. cytokines [8, 25], and we have recently demonstrated that polysulfone absorbs serum factors that have a leucocyte-activating effect [26]. However, the levels of C3a measured in our study are within the range found in predialysis serum samples, analysed by the same technique, from uremic patients [27], making the clinical impact of C3a in our platelet concentrates ambiguous.…”

Section: Discussionmentioning

confidence: 99%

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Kinetics of Bradykinin Levels during and after Leucocyte Filtration of Platelet& ;Concentrates

et al. 1998

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Objective: To measure beadykinin levels in platelet concentrates during and after leucocyte filtration. Methods: Platelet concentrates were leukocyte depleted using three different leucocyte-depletion filters selected to represent filters with negative, positive or neutral charge, respectively. Bradykinin levels were analysed before, during and up to 90 min post-filtration. Results: Significant levels of bradykinin were generated when negatively charged leucocyte depletion filters were used. However, we found a high variation between platelet concentrates prepared from different donors as well as within the same concentrate when this was divided into three aliquots. Generated bradykinin was rapidly degraded in the collection bag and no bradykinin was detectable 60 min post-filtration. Conclusion: Bradykinin generation is more pronounced when negatively charged leucocyte removal filters are used. Due to a rapid degradation of bradykinin in the storage bag, pre-storage filtration should minimise the risk of bradykinin related adverse reactions during transfusion with some filters.

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Section: Discussionmentioning

confidence: 99%

“…It has also been proposed that post-storage filtration can remove biologically active products generated during storage (e.g. C3a) [8]. …”

Section: Introductionmentioning

confidence: 99%

Kinetics of Bradykinin Levels during and after Leucocyte Filtration of Platelet& ;Concentrates

et al. 1998

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“…In non-leucocyte-reduced platelets, whether prepared from whole blood, by the buffy-coat method, or by apheresis, there is progressive accumulation of CXCL4, CXCL7, CCL5 and CXCL8 [68][69][70][71][72][73]. CXCL8 can reach particularly high levels in non-leucoreduced platelets by the end of the storage period.…”

Section: Accumulation Of Chemokines During Blood Component Storagementioning

confidence: 99%

“…CXCL8 can reach particularly high levels in non-leucoreduced platelets by the end of the storage period. Pre-storage leucocyte reduction can prevent the accumulation of leucocyte-derived CXCL8, but not platelet-derived chemokines [68,69,71,[73][74][75][76]. Photochemical pathogen reduction treatment or ultraviolet B irradiation prevents accumulation of leucocyte-derived chemokines, but γ -irradiation does not [70,77,78].…”

Section: Accumulation Of Chemokines During Blood Component Storagementioning

confidence: 99%

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An introduction to chemokines and their roles in transfusion medicine

Davenport

2009

Vox Sanguinis

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Chemokines are a set of structurally related peptides that were first characterized as chemoattractants and have subsequently been shown to have many functions in homeostasis and pathophysiology. Diversity and redundancy of chemokine function is imparted by both selectivity and overlap in the specificity of chemokine receptors for their ligands. Chemokines have roles impacting transfusion medicine in haematopoiesis, haematologic malignancies, transfusion reactions, graft-versus-host disease, and viral infections. In haematopoietic cell transplantation, chemokines are active in mobilization and homing of progenitor cells, as well as mediating T-cell recruitment in graft-versus-host disease. Platelets are rich source of chemokines that recruit and activate leucocytes during thrombosis. Important transfusion-transmissible viruses such as cytomegalovirus and human immunodeficiency virus exploit chemokine receptors to evade host immunity. Chemokines may also have roles in the pathophysiology of haemolytic and non-haemolytic transfusion reactions.

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Assessment of complement activation during membrane‐based plasmapheresis procedures

Burnouf¹,

Eber²,

Kientz

et al. 2004

J of Clinical Apheresis

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Previous studies have suggested that plasmapheresis procedures using a separation membrane may activate the complement system and release anaphylatoxins. This study determines the content in C3a/C3a(des Arg) and C5a/C5a(des Arg) in plasma donations obtained by the new Haemonetics Filter Core (FC) procedure and compares it to Baxter Autopheresis C (Auto-C). FC performs sequential blood centrifugation and plasma filtration on a microporous polyethersulfone membrane, while Auto-C removes blood cells by simultaneous gravitation and filtration on a rotating nylon membrane. One group of 34 donors donated on FC and two groups of 30 and 10 donors on Auto-C. Plasma aliquots were taken from the plasma units within 30 min of the end of the collection procedures, frozen at < -30 degrees C and assessed for C3a and C5a at various time points of storage. Mean C3a/C3a(des Arg) in FC plasma (N = 34) was 1,151 (range: 526-2,991), 1,092 (range: 349-3498), and 507 (range: 307-815) ng/ml at time of collection and after 6 and 12 months of storage, respectively. Respective C5a/C5a(des Arg) was 26.6 (range 4.9-74), 18.9 (9.5-42.6), and 30.9 (range: 10.7-62.3) ng/ml. Mean C3a/C3a(des Arg) was higher in Auto-C (P < 0.001): 4,724 ng/ml (N = 10; range: 2,400-7 ,360) and > 4,149 ng/ml (N = 30; 2,408- > 6,430) after 3 and 18 months storage, respectively. Mean C5a/C5a(des Arg) was 32.1 ng/ml (N = 30; range: 10.6-57.2) after 18 months of storage. Complement activation in FC plasmas appears limited compared to Auto-C, suggesting better biocompatibility of this collection device and/or a favourable impact of the sequential cell centrifugation/filtration technology used. Further studies are needed to explain differences in complement activation between apheresis procedures and to assess clinical impacts, if any.

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Removal of soluble biologic response modifiers (complement and chemokines) by a bedside white cell‐reduction filter

Cited by 29 publications

References 40 publications

Kinetics of Bradykinin Levels during and after Leucocyte Filtration of Platelet& ;Concentrates

Kinetics of Bradykinin Levels during and after Leucocyte Filtration of Platelet& ;Concentrates

An introduction to chemokines and their roles in transfusion medicine

Assessment of complement activation during membrane‐based plasmapheresis procedures

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