Removal of surface-attached micro- and nanobubbles by ultrasonic cavitation in microfluidics

Ren, Zibo; Xu, Peng; Han, Huan; Ohl, Claus-Dieter; Zuo, Zhigang; Liu, Shuhong

doi:10.1016/j.ultsonch.2024.107011

Ultrasonics Sonochemistry

2024

DOI: 10.1016/j.ultsonch.2024.107011

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Removal of surface-attached micro- and nanobubbles by ultrasonic cavitation in microfluidics

Zibo Ren,

Peng Xu,

Huan Han

et al.

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Cited by 2 publications

References 55 publications

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Investigating the bacterial cleaning performance on Zr-BMG with LIPSS after ultrasonic vibration assisted cleaning

Li,

Mo,

2024

Proc Inst Mech Eng H

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High-efficiency and high-quality sterilization technologies for medical materials can significantly reduce iatrogenic infection. This study investigates the synergistic effects of laser-induced periodic surface structures (LIPSS) and ultrasonic cleaning on the removal of bacteria from medical material surfaces. We specifically examined how ultrasonic parameters and structural defects in LIPSS impact the effectiveness of bacterial removal. As an emerging medical metal, Zr-BMG was chosen for the target material. Femtosecond laser processing was employed to create LIPSS with both complete linear arrays and discontinuous linear arrays structures featuring surface defects by adjusting the scanning overlap rate. A high-concentration solution of S. aureus was used for co-cultivation, resulting in a surface bacterial coverage rate exceeding 95%. The study analyzed the synergistic sterilization effect of microstructured surfaces through variations in ultrasonic cleaning power and duration. The results indicated that surfaces with microstructures demonstrated significantly improved bacterial removal following ultrasonic cleaning. The bacterial removal rate was found to be proportional to the ultrasonic vibrator power, and the surface with a LIPSS structure outperformed the discontinuous LIPSS surface in bacterial removal efficiency. Optimal results were achieved with the LIPSS surface after 30 min of cleaning at 100 W ultrasonic power. However, there was minimal difference in bacterial removal between 10 and 30 min at the same power level. This study aims to provide methodological insights and data support for the efficient and high-quality cleaning of medical metal surfaces.

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Investigating the bacterial cleaning performance on Zr-BMG with LIPSS after ultrasonic vibration assisted cleaning

Li,

Mo,

2024

Proc Inst Mech Eng H

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Clinical Applications of Micro/Nanobubble Technology in Neurological Diseases

Patel,

Latt,

Ravi

et al. 2024

Biomimetics

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Nanomedicine, leveraging the unique properties of nanoparticles, has revolutionized the diagnosis and treatment of neurological diseases. Among various nanotechnological advancements, ultrasound-mediated drug delivery using micro- and nanobubbles offers promising solutions to overcome the blood-brain barrier (BBB), enhancing the precision and efficacy of therapeutic interventions. This review explores the principles, current clinical applications, challenges, and future directions of ultrasound-mediated drug delivery systems in treating stroke, brain tumors, neurodegenerative diseases, and neuroinflammatory disorders. Additionally, ongoing clinical trials and potential advancements in this field are discussed, providing a comprehensive overview of the impact of nanomedicine on neurological diseases.

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Removal of surface-attached micro- and nanobubbles by ultrasonic cavitation in microfluidics

Cited by 2 publications

References 55 publications

Investigating the bacterial cleaning performance on Zr-BMG with LIPSS after ultrasonic vibration assisted cleaning

Investigating the bacterial cleaning performance on Zr-BMG with LIPSS after ultrasonic vibration assisted cleaning

Clinical Applications of Micro/Nanobubble Technology in Neurological Diseases

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