2021
DOI: 10.1021/acs.est.1c06232
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Renaissance for Phage-Based Bacterial Control

Abstract: Bacteriophages (phages) are an underutilized biological resource with vast potential for pathogen control and microbiome editing. Phage research and commercialization have increased rapidly in biomedical and agricultural industries, but adoption has been limited elsewhere. Nevertheless, converging advances in DNA sequencing, bioinformatics, microbial ecology, and synthetic biology are now poised to broaden phage applications beyond pathogen control toward the manipulation of microbial communities for defined f… Show more

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Cited by 21 publications
(9 citation statements)
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“…Currently, many Erwinia species are described as economically important plant pathogens, including E. pyrifoliae [ 2 ], E. tracheiphila [ 3 ], and E. psidii [ 4 ]. The management of Erwinia disease in plants includes the use of antibiotics, such as streptomycin, but the emergence of bacterial resistance [ 5 ] and policies to restrict its use makes necessary the development of alternative control strategies, such as bacteriophage control [ 6 , 7 ].…”
Section: Introductionmentioning
confidence: 99%
“…Currently, many Erwinia species are described as economically important plant pathogens, including E. pyrifoliae [ 2 ], E. tracheiphila [ 3 ], and E. psidii [ 4 ]. The management of Erwinia disease in plants includes the use of antibiotics, such as streptomycin, but the emergence of bacterial resistance [ 5 ] and policies to restrict its use makes necessary the development of alternative control strategies, such as bacteriophage control [ 6 , 7 ].…”
Section: Introductionmentioning
confidence: 99%
“…Other techniques suggest altering selective pressures to improve strain survival . Recent progress has also been made in “niche clearing” using bacteriophages . Employing this technique, researchers can perform precise microbiome editing, allowing for the suppression of specific microbial activities, which may open niches for inoculated strains.…”
Section: Genetically Modified Plants Bacteria and Editing The Microbiomementioning
confidence: 99%
“… 85 Recent progress has also been made in “niche clearing” using bacteriophages. 87 Employing this technique, researchers can perform precise microbiome editing, allowing for the suppression of specific microbial activities, which may open niches for inoculated strains. Furthermore, this technique may improve various plant traits, such as increased drought and disease resistance.…”
Section: Genetically Modified Plants Bacteria and Editing The Microbiomementioning
confidence: 99%
“…While lytic phages are generally preferred for phage therapy and biocontrol applications 21 , concerns around endotoxin release during bacterial lysis have prompted a search for alternative non-lytic strategies 22 , including the use of chronic phages. Chronic phages have been used to deliver regulatory RNAs to silence antibiotic resistance genes in bacteria 23 , edit microbiomes 15 , or even kill targeted bacteria by non-lytic means 12,22 .…”
Section: Introductionmentioning
confidence: 99%