Renal adaptation to alteration in dietary amino acid intake

Friedman, Amy L.; Albright, Patti W.; Gusowski, Naomi; Padilla, Marcia L.; Chesney, Russell W.

doi:10.1152/ajprenal.1983.245.2.f159

Cited by 18 publications

(25 citation statements)

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“…The composition of the diet is described in detail elsewhere (3,4,17). Briefly each diet (LTD, HTD, or normal taurine diet (NTD)] is isoproteinic and contains soy protein which contains limited amounts of methionine and cysteine.…”

Section: Methodsmentioning

confidence: 99%

“…Evidence for the adaptive response occurs within 72 h after initiation of diet (1 7) and is completely established within 6 days. Animals consuming the LTD, which is limiting in methionine and cysteine are 13 k 2% smaller at the end of the 14 days (3,4,17). No attempts are made to pair-feed these animals since the LTD-fed group actually ingests more food.…”

Section: Methodsmentioning

confidence: 99%

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Membrane Fluidity and Phospholipid Composition in Relation to Sulfur Amino Acid Intake in Brush Border Membranes of Rat Kidney

1986

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ABSTRAn. The transport of ions and solutes across PS, phosphatidylserine biological membranes may relate to changes in the lipid PE, phosphatidylethanolamine microenvironment of the membrane which could alter the PG, phosphatidylglycerol activity or configuration of transport sites. Changes in the ANOVA, analysis of variance sulfur amino acid content of diets fed to young rats results in an increase in Na+-taurine symport in brush border membranes isolated from animals fed a low sulfur amino acid diet and a reduction in symport after a high taurine diet in comparison to uptake by membranes from normally fed animals ("the renal adaptive response"). We explored the possibility that diet-induced changes in brush border membrane symport relate to altered membrane fluidity and phospholipid composition in response to diet. An Arrhenius plot of initial rate (15 s) taurine uptake in breakpoint at 22" C, but no change in relation to dietary alteration.Fluorescence polarization data employing the probe 1-6-diphenyl-1,3,5-hexatriene best fits a two-phase linear model employing a computer model fitting program. Dietary manipulations did not change the breakpoint upper segment slope or lower segment slope after incubating fresh membranes with DPH over the temperature range 4-56" C. No change was evident in membrane phospholipid composition in relation to diet. This study indicates that the changes in initial rate Na+-taurine symport in relation to diet are less likely to be due to changes in the configuration of the transporter from an alteration of the lipid microenvironment of the membrane. (Pediatr Res 20: 1305-1309, 1986 Abbreviations LTD, low sulfur amino acid diet NTD, normal sulfur amino acid diet HTD, high taurine diet DPH, 1,6-diphenyl-1,3,5-hexatriene tPnA, transparanic acid TMA-DPH, 1,-(4-trimethylammoniumphenyl)-6-phenyl- Renal tubular epithelium is capable of adapting to changes in the dietary intake of various nutrients. This renal adaptive response has been demonstrated for the @-amino acid, taurine, which is conserved following diminished sulfur amino acid intake and hyperexcreted in the urine after dietary taurine excess (1-3). Studies employing isolated luminal brush border membrane vesicles are consistent with these changes in urinary excretion of taurine occurring as the consequence of a membrane-related event (3, 4), since the LTD appears to increase the Vmax of initial Naf-taurine symport and the HTD decrease the Vmax of uptake into vesicles. We conducted these studies to determine if these diets influence the microviscosity and phospholipid composition of these vesicles.Changes in the physical status or in the lipid composition of biological membranes can alter the movement of ions and solutes across these membranes (5). The technique of fluorescence polarization has been employed to define the "fluidity" of hepatic, erythrocyte, bacterial cell, gastrointestinal, and renal plasma membranes (6-1 1). The importance of the lipid microenvironment of biological membranes is also of interest since the activ...

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Membrane Fluidity and Phospholipid Composition in Relation to Sulfur Amino Acid Intake in Brush Border Membranes of Rat Kidney

1986

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“…There are few pathways for taurine metabolism in humans (7,8,22), and urinary taurine excretion may play an important role in regulating body taurine pools (23)(24)(25)(26). Both group 1 and group 2 patients showed a remarkable degree of renal conservation of taurine; their urinary taurine excretion averaged 16% of normal (Table 4).…”

Section: Plasma Taurine (Pmoles/liler)mentioning

confidence: 99%

Taurine Concentrations in Plasma, Blood Cells, and Urine of Children Undergoing Long-Term Total Parenteral Nutrition

et al. 1987

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ABSTRACT. Taurine concentrations in plasma, platelets, lymphocytes, granulocytes, erythrocytes, and urine were measured in 19 children who were undergoing long-term home parenteral nutrition for 27.4 k 7.1 (SEM) months. The parenteral solutions contained methionine, but not taurine or cysteine. The patients' plasma, platelet, and urine taurine concentrations were significantly reduced to 54, 48, and 16%, respectively, of the values from normal children of similar ages. The most significant reductions in plasma and platelet taurine concentrations were observed in the children who were estimated to absorb less than 5% of their daily calorie needs from the enteral tract. Lymphocyte and erythrocyte taurine levels tended to be lower but were not significantly different from those in normal children. The patients' plasma methionine and cystine levels were not different from normal. There was a direct correlation between plasma and platelet taurine concentrations and between plasma and urine taurine. Both plasma and platelet taurine tended to be directly correlated with age and, after the 1st yr of total parenteral nutrition, with the duration of total parenteral nutrition therapy. The question of whether taurine (2-aminoethanesulfonic acid) may be an indispensable amino acid for humans has been the subject of much research in recent years. Studies in premature and term infants have shown that a low or absent dietary taurine intake (either from formula feedings or parenteral nutrition solutions) is associated with low plasma and urine taurine levels (1-5). We have previously reported that children undergoing long-term TPN at home with solutions that do not contain taurine have low plasma taurine levels and abnormal ERG (6). These studies suggest that taurine is an indispensable amino acid.However, taurine, which is one of the most abundant free amino acids (i.e. not bound in peptides or protein) in the human body, resides almost entirely within the cell. Intracellular taurine

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“…Thus, the renal adaptive response to changes in sulfur amino acid intake is found in the brush border membrane, but the urinary excretion pattern is only partially adapted. It is possible that delayed emux of taurine across the basolateral surface accounts for this excessive taurinuria, since our previous studies have indicated reduced basallateral efflux in immature rats (4,6,7).Although the adaptive response has been shown to partially exist in terms of urinary excretion and to fully exist at the apical surface in 28-day-old rats, little is known about the response in nursing animals at this membrane surface. Herein we describe the influence of the altered amino acid diets fed to the mothers of nursing rats on the renal handling and brush border accumu-…”

mentioning

confidence: 99%

mentioning

confidence: 99%

Development Aspects of Renal β-Amino Acid Transport. V Brush Border Membrane Transport in Nursing Animals—Effect of Age and Diet

et al. 1986

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ABSTRACT. This study examines the Na+-dependent accumulation of the &amino acid, taurine, by brush border membrane vesicles isolated from nursing animals compared to uptake in adult animals. The diets fed to the mothers nursing these pups were altered so as to provide a low sulfur amino acid intake or a high taurine diet as well as conventional sulfur amino acid intake. Taurinuria is greater in nursing animals than in adult controls, but animals of all ages respond to exposure to the low sulfur amino acid intake by conservation of taurine and to the high taurine diet by hyperexcretion of taurine. Taurine uptake at 10 pM by brush border membrane vesicles is influenced by age in all groups and by diet in 14-and 21-day-old animals. A precession of uptake is seen both in terms of initial and peak rate of uptake with the lowest values in 7-day-old animals to the highest in adult. Greater brush border membrane vesicle uptake is found in 14-and 21-day-old rats after exposure to the low sulfur amino acid intake and reduced uptake after the HTD, whereas no dietary influence on uptake was found in 7-day-old rats. Neither the pattern of the time course of uptake nor the uptake values at equilibrium (45 min) are affected by age or diet. Kinetic analyses of concentration dependent uptake show that the maturational process involves a change in the Vmax of initial uptake. Kinetic analysis of the adaptive response reveals an increase in Vmax after low sulfur amino acid intake and a decline after high taurine diet in 14-and 21-day-old pups, but not in 7-day-old pups. Uptakes at high taurine concentrations (5 mM) which are 10-fold higher than the Km are uninfluenced by age or diet. This study indicates that the physiologic taurinuria of immature rats may relate, in part, to a lower rate of uptake at the brush border surface, but that after 1 wk and before 2 wk of age the kidney can adapt to changes in sulfur amino acid intake. (Pediatr Res 202390-894,1986 The renal tubular epithelium is involved in the reabsorption of various ions and nutrients, including amino acids that arise by virtue of filtration across the glomerular basement membrane. A "physiologic" aminoaciduria is evident in the young of all mammalian species. On the surface, aminoaciduria seems inappropriate in view of the need for a young, rapidly growing animal to conserve compounds that are important in growth (I, 2). Our lab has been concerned with those factors that contribute to the development of amino acid transport processes in the maturing animal and we hope to understand more fully whether maturation of the transport process can be accelerated by various physiologic manipulations (3-7). We have used as a transport probe, the p-amino acid, taurine, since one can manipulate the dietary intake of sulfur amino acids which results in a renal adaptive response for taurine (5,(8)(9)(10)(11)(12)(13).Full grown rats fed a limited sulfur amino acid intake reduce their urinary taurine excretion, a finding which is paralleled in vitro by augmented uptake of taurine by c...

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Renal adaptation to alteration in dietary amino acid intake

Cited by 18 publications

References 0 publications

Membrane Fluidity and Phospholipid Composition in Relation to Sulfur Amino Acid Intake in Brush Border Membranes of Rat Kidney

Membrane Fluidity and Phospholipid Composition in Relation to Sulfur Amino Acid Intake in Brush Border Membranes of Rat Kidney

Taurine Concentrations in Plasma, Blood Cells, and Urine of Children Undergoing Long-Term Total Parenteral Nutrition

Development Aspects of Renal β-Amino Acid Transport. V Brush Border Membrane Transport in Nursing Animals—Effect of Age and Diet

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