Renal Amyloid

Heptinstall, R. H.; Joekes, A. M.

doi:10.1136/ard.19.2.126

Cited by 40 publications

(8 citation statements)

References 8 publications

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“…Besides, intermittent albuminuria was observed with a severe degree of amyloid deposition. Almost similar findings, although based on a smaller number of cases, were also recorded by Heptinstall & Joekes (1960) in renal amyloidosis, and by Berman & Voglestrong (1963) and Cohen & Levitt (1963), in cases of glomerulonephritis.…”

Section: Discussionsupporting

confidence: 70%

“…Most of these have been done in glomerulonephritis and comparatively few in renal amyloidosis, although the disease is not uncommon in India as well as in the West (Briggs, 1961;Vaishnava, Gulati & Aurora, 1969). However, in recent years, a few reports indicating divergent views on the correlation of glomerular changes with functional alterations in amyloid disease of the kidney have appeared in the literature (Bell, 1950;Heptinstall & Joekes, 1960;Bergstrand & Bucht, 1961).…”

Section: Introductionmentioning

confidence: 99%

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Correlation of clinical, biochemical and functional parameters with histological lesions in secondary renal amyloidosis

Gulati

Mathur

Aurora

et al. 1970

Postgraduate Medical Journal

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Summary The records of fifty-five patients with secondary renal amyloidosis have been scrutinized in order to evaluate statistically the correlation of the various clinical features and biochemical alterations with the severity of histological lesions in this disease. An ‘amyloid factor’, calculated on the basis of the extent of glomerular amyloid deposition, was utilized for the grading of the latter. A significant correlation of the histological grading was observed with the duration of predisposing illness (P <0·02), alteration of total serum protein (P <0·001) and functional impairment as determined by the creatinine clearance test (P <0·002). There was, however, no significant correlation between the extent of glomerular lesions and clinical severity, the duration of oedema, the degree of proteinuria and the levels of blood urea, serum albumin and serum cholesterol.

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Section: Discussionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Correlation of clinical, biochemical and functional parameters with histological lesions in secondary renal amyloidosis

Gulati

Mathur

Aurora

et al. 1970

Postgraduate Medical Journal

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“…Nevertheless, our findings show that the fine granular deposits in the mesangium correspond to protein precipitates which, according to Olsen, could precede the increase of basement membrane-like substance in this region. Amyloid deposits (Teilum and Lindahl, 1954;Heptinstall and Joekes, 1960;Olsen, 1972;Lendrum, Slidders, and Fraser, 1972) could neither be demonstrated by light nor by electron microscopy in our cases. Thus, although we have not completely clarified the nature of these nodules of plasmacytoma, our electron microscopic results point strongly toward a structure consisting of protein deposits and a scanty collagen fibre synthesis in the marginal sections of the glomerulus.…”

Section: Discussioncontrasting

confidence: 63%

Glomerular nodules and long-spacing collagen in kidneys of patients with multiple myeloma

Schubert

Adam

1974

J Clin Pathol

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Light microscopic examination of the kidneys in 170 patients with multiple myeloma revealed three from patients without diabetes with glomerular nodules that were indistinguishable from those of diabetic glomerular sclerosis. Electron microscopic studies showed the nodules to be deposits of fine-grained material that corresponded to precipitations of protein but lacked the basement-membrane-like material characteristic of nodular glomerulosclerosis in diabetics. What is more, a unique collagen was observed in the marginal area of the nodules and in the periglomerular interstitium. The possible causes of the origin and distribution of this collagen not so far described in the human kidney are discussed.

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“…Approximately 50% of the present patients had presented with a nephrotic syndrome. The reported incidence of this complication varies from 32-68 % (Heptinstall and Joekes, 1960;Brandt et al, 1968;Triger and Joekes, 1973;Kennedy et al, 1974;Kyle and Bayrd, 1975). Heavy proteinuria is not uncommon and 30 out of 233 patients (12-9%) in the present series had a 24-hr protein excretion of more than 10 g. Amyloidosis is one condition in which heavy proteinuria may persist even when there has been a considerable decline in the glomerular filtration rate (Brandt et al, 1968).…”

Section: Discussionmentioning

confidence: 63%

“…In some studies, tuberculosis has been reported as accounting for more than 80% of cases of secondary amyloidosis (Dahlin, 1949;Heptinstall and Joekes, 1960). Although most studies have reported that secondary amyloidosis is much more common than the primary variety (Brandt et al, 1968;Triger and Joekes, 1973), a more recent report by Kyle and Bayrd (1975) recorded only 19 cases of secondary amyloidosis in their series of 236 patients.…”

Section: Discussionmentioning

confidence: 98%

Pattern of renal amyloidosis in Indian patients

Chugh

Datta

et al. 1981

Postgraduate Medical Journal

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SummaryTwo hundred and thirty-three patients with renal amyloidosis were studied in an attempt to identify the incidence and pattern of the disease in northern India. The incidence of amyloidosis was 1 01% of 6431 postmortems and 8-4 % of 1980 renal biopsies from patients who presented with clinical evidence of glomerular disease. Two hundred and three patients (87 1 %) had secondary amyloidosis, 22 (9-4 %) had primary amyloid and 8 patients (3 5 %) had amyloidosis associated with multiple myeloma. Tuberculosis of various organs was the commonest predisposing disease accounting for 59 1% of secondary amyloidosis, followed by chronic suppurative lung disease in 241 %. Rheumatoid arthritis, chronic osteomyelitis and lepromatous leprosy were seen in a small percentage of patients (2 to 8 %). Proteinuria of varying degree was present in all the 233 patients and 12-9 % of them had a daily protein excretion of more than 10 g.Post-mortem examination of 65 patients with renal amyloidosis showed that 75-3 % also had amyloid deposit in the spleen, 63 % in the liver, and 50 8 % in the adrenals.

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Renal Amyloid

Cited by 40 publications

References 8 publications

Correlation of clinical, biochemical and functional parameters with histological lesions in secondary renal amyloidosis

Correlation of clinical, biochemical and functional parameters with histological lesions in secondary renal amyloidosis

Glomerular nodules and long-spacing collagen in kidneys of patients with multiple myeloma

Pattern of renal amyloidosis in Indian patients

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