Renal amyloidosis complicating multidrug-resistant tuberculosis

Chong, Sy Giin; Herron, Malcolm; Dorman, Anthony; Little, Mark A.; Donnelly, Seamas C.; Keane, Joseph; McLaughlin, Anne Marie

doi:10.5588/ijtld.16.0823

Cited by 3 publications

(1 citation statement)

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“…In human cases of infection where irreversible kidney damage occurs, there are commonly co‐morbidities. Amyloidosis is one such co‐morbidity, particularly recognized across India, which predisposes to glomerulonephritis and potentially fatal nephrotic syndrome (Chong et al., ; Sanz‐Martín, Samillán‐Sosa Kdel, De Miguel, & Martínez‐Miguel, ). This may also be the case for dogs; Foxhounds have previously been reported to be affected by renal amyloidosis (Mason & Day, ), and this kennel has had previously confirmed clinical cases, and one of the M. bovis infected hounds was found to be positive for renal amyloidosis (data not shown).…”

Section: Discussionmentioning

confidence: 99%

An outbreak of tuberculosis due toMycobacterium bovisinfection in a pack of English Foxhounds (2016-2017)

O’Halloran

Hope

Dobromylskyj³

et al. 2018

Transbound Emerg Dis

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Mycobacterium bovis can cause tuberculosis (TB) in social mammals including lions, cattle and man, but canine infections are considered rare. In 2016/17 we investigated a M. bovis TB outbreak in a pack of approximately 180 Foxhounds within the bovine TB Edge Area of England. We employed a combination of immunological tests including an interferon gamma release assay (IGRA) and a serological assay (DPP VetTB, Chembio). Test‐positive hounds were euthanased and subjected to post‐mortem examination (PME). Overall 164 hounds were tested; 97 (59%) responded positively to at least one test. Eighty‐five (52%) dogs responded to M. bovis antigens by IGRA while only 21 (12.9%) had detectable serological responses. At PME three hounds (3.1%) had visible lesions (VL) due to M. bovis infection, later confirmed by culture. Samples from 24 non‐VL hounds were cultured and M. bovis infection was confirmed in a further three hounds (11%). This study is the first investigation and report of an outbreak of M. bovis TB in a canine species. We establish that, in principle, diagnostic tests used for identifying infected individuals of other species can effectively be used in the dog. Further work is urgently needed to establish the sensitivity and specificity of the testing approach used in this study for future clinical application.

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Section: Discussionmentioning

confidence: 99%