Renal and adrenal responses to converting-enzyme inhibition in fetal and newborn life

Robillard, J; Weismann, Douglas N.; Gómez, R. Ariel; Ayres, Nancy A.; Lawton, William J.; VanOrden, D

doi:10.1152/ajpregu.1983.244.2.r249

Cited by 43 publications

(49 citation statements)

References 35 publications

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“…However, the absence of significant changes in plasma A-I1 concentrations in the present study is against a role for the reninangiotensin system to influence changes in renal hemodynamics and renal function during the transition from fetal to newborn life. In this respect, the present findings confirm previous results suggesting that the renin-angiotensin system plays a minor role in controlling GFR in newborn animals (32,33).…”

Section: Bloodsupporting

confidence: 92%

Renal Hemodynamics and Functional Changes during the Transition from Fetal to Newborn Life in Sheep

et al. 1987

Pediatr Res

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Section: Bloodsupporting

confidence: 92%

Renal Hemodynamics and Functional Changes during the Transition from Fetal to Newborn Life in Sheep

et al. 1987

Pediatr Res

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“…The renin angiotensin system is highly activated at birth and during the maturation of renal hemodynamics (43-45). However, the contribution of angiotensin I1 as a vasoconstrictor in maintaining immature renal hemodynamics has not been demonstrated (14)(15)(16). The participation of vasodilators in the maturation of renal hemodynamics has received limited examination.…”

Section: 'mentioning

confidence: 99%

“…facilitates the matu---, rational increase in renal blood flow, remain largely unexplained. Previous investigations to explain the developmental phenomenon of renal hernodynamics have focused o n vasoconstrictor mechanisms such as an increased sympathoadrenergic response (8)(9)(10)(11)(12)(13), the highly activated renin angiotensin system (14)(15)(16), or activation of the prostanoid thromboxane ( 17). Prostaglandins, the only vasodilators examined, may participate in fetal renal hemodynamics (18) but have not been proven to regulate basal renal hemodynamics in the developing animal (1 5).…”

mentioning

confidence: 99%

Endothelium-Derived Nitric Oxide Modulates Renal Hemodynamics in the Developing Piglet

1993

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ABSTRACT. The developing mammal exhibits lower renal blood flow (RBF) and higher renal vascular resistance (RVR) than its adult counterpart. The maturational pattern of renal hemodynamics involves the synchronous increase in RBF and decrease in RVR with age. In spite of considerable investigation, the mechanisms involved in the regulation of renal hemodynamics in the developing animal remain largely unexplained. Specifically, the role of the vasodilator endotheliumderived nitric oxide (EDNO) in the regulation of developing renal hemodynamics is not known. These experiments examined the intrarenal effect on the renal hemodynamics of the developing piglet and adult pig of the EDNO competitive inhibitor N-nitro-Larginine methylester (L-NAME) at three doses (50,5, and 3 pg/kg/min). During basal conditions, the developing piglet exhibited lower RBF and higher RVR than the adult pig. All doses of intrarenal L-NAME produced significant decreases in RBF and increases in RVR in both groups. The 3-pg/kg/min L-NAME dose did not change mean arterial pressure. The developing piglet exhibited significantly greater changes at all doses. After the 50-pg/kg/min infusion, piglet RBF decreased 45% and adult pig RBF decreased 29%; piglet RVR increased 128% and adult pig RVR increased 51%. After a 5-pg/kg/min infusion, RBF

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“…However, it has been demonstrated that inhibition of kininase I1 using captopril does not modify urinary sodium and water excretion (34).…”

Section: Discussionmentioning

confidence: 99%

Effects of Aldosterone on Urinary Kallikrein and Sodium Excretion during Fetal Life

et al. 1985

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ABSTRACT. The present study was designed to investigate the effect of acute (2 h) and chronic aldosterone (4 days) infusion on urinary kallikrein excretion rate and on renal handling of Na+ and K+ in chronically catheterized fetal lambs e l 1 5 days gestation (n = 6) and >I25 days gestation (n = 7). Chronic aldosterone infusion decreased plasma renin activity in both groups of fetuses. Both acute and chronic aldosterone infusion produced significant decreases in UNa + V in fetuses >I25 days and in the majority of fetuses e l 1 5 days gestation (five of six). Aldosterone infusion did not increase K+ excretion in either group of fetuses. It is also demonstrated that chronic aldosterone infusion induced an increase in urinary kallikrein excretion rate in both groups of fetuses. Taken together, these results demonstrate that aldosterone has antinatriuretic but no kaliuretic effects during fetal life, but produces a rise in urinary kallikrein excretion rate during the last trimester of gestation in fetal lambs. (Pediatr Res 19: 1048-1052,1985 Abbreviations UKall, urinary kallikrein PRA, plasma renin activity HUK, human urinary kallikrein 'H-TAME, N-(p-tosy1)-1-arginine-PHI-methyl ester-hydrochlorideAldosterone acts on the kidney to increase sodium reabsorption in exchange for either potassium or hydrogen ion (I) and to stimulate renal kallikrein production (2). However, the role of aldosterone on the fetal renal function is not well defined. In respect to sodium metabolism, it has been shown that the percentage of filtered sodium excreted is elevated during fetal life (3,4) and in premature infants (5) suggesting a partial unresponsiveness of the distal nephron to aldosterone.On the other hand, it has been demonstrated that UKall excretion rate increases significantly during the last trimester of gestation in fetal lambs (6). Since this rise correlated with an increase in plasma aldosterone concentration, it was suggested that aldosterone may be an important modulator of renal kallikrein production during renal maturation (6).The present study was designed to explore in detail the effect of acute and chronic administration of aldosterone on UKall excretion rate during the last trimester of gestation in chronically Received April 5, 1985; accepted June 4, 1985 catheterized fetal lambs. Moreover, the quantitative relationship between plasma levels of aldosterone and renal handling of sodium and potassium was also evaluated. METHODSAnimal preparation and surgical procedures. The fetuses of 13 pregnant sheep of Dorset and Suffolk mixed breeding were studied. Six fetuses were between 99 and 107 days gestation (group I) and seven fetuses were between 125 and 13 1 days gestation (group 11) (term was 145 days) at the time of surgery. Gestational ages were based on the induced ovulation technique as described previously (7).Prior to surgery, the animals were fasted for 48 h. Anesthesia of the ewe and surgery of the fetus were performed as described previously (8). Briefly, the pregnant ewe was anesthetized using a mixture of...

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Renal and adrenal responses to converting-enzyme inhibition in fetal and newborn life

Cited by 43 publications

References 35 publications

Renal Hemodynamics and Functional Changes during the Transition from Fetal to Newborn Life in Sheep

Renal Hemodynamics and Functional Changes during the Transition from Fetal to Newborn Life in Sheep

Endothelium-Derived Nitric Oxide Modulates Renal Hemodynamics in the Developing Piglet

Effects of Aldosterone on Urinary Kallikrein and Sodium Excretion during Fetal Life

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