Renal and perirenal space involvement in acute pancreatitis: An MRI study

Li, Xing Hui; Zhang, Xiao Ming; Ji, Yi Fan; Jing, Zong Lin; Huang, Xiao; Yang, Lin; Zhai, Zhao Hua

doi:10.1016/j.ejrad.2012.04.032

Cited by 13 publications

(11 citation statements)

References 17 publications

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“…The criteria for exclusion were the following: (1) chronic pancreatitis; (2) intra- or retroperitoneal tumors, inflammation or hemorrhagic diseases; (3) poor compliance in MR examination and (4) hypoproteinemia [1]. 12 patients met the exclusion criteria (3 met Condition 1, 2 met Condition 2, 5 met Condition 3, 2 met Condition 4) and were excluded from the final study.…”

Section: Methodsmentioning

confidence: 99%

“…The incidence of AP is increasing worldwide with approximately 210,000 people admitted to the hospital in the United States annually of which about 5% die [1, 2]. Among all the AP patients, 20–30% of AP patients develop severe necrosis pancreatitis with high morbidity and mortality rate up to 20% -45% [3, 4].…”

Section: Introductionmentioning

confidence: 99%

“…Among all the methods, CTSI based on combined assessment of peripancreatic fluid collections and the degree of pancreatic necrosis, was considered as the golden standard to assess the degree of severity, extent of necrosis, local complications and prognosis of clinical outcome [21]. Nevertheless, CT involves radiation exposure and iodinated contrast media, which is not suitable for patients with functional renal impairment or a history of allergic-type reactions to iodinated contrast material[1]. Arvanitakis M et al [22] and Stimac D et al [23] demonstrated that MRSI had a significant correlation with CTSI on C-reactive protein (CRP) levels 48 hours after admission, clinical outcome, length of hospital stay.…”

Section: Introductionmentioning

confidence: 99%

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Preliminary Study of MR Diffusion Tensor Imaging of Pancreas for the Diagnosis of Acute Pancreatitis

Zhuang

Zhang

et al. 2016

PLoS ONE

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ObjectivesTo evaluate the feasibility of differentiating between acute pancreatitis (AP) and healthy pancreas using diffusion tensor imaging (DTI) and correlate apparent diffusion coefficient (ADC) /fractional anisotropy (FA) values with the severity of AP.Material and Methods66 patients diagnosed with AP and 20 normal controls (NC) underwent DTI sequences and routine pancreatic MR sequences on a 3.0T MRI scanner. Average ADC and FA values of the pancreatic were measured. Differences of FA and ADC values between the AP group and the NC group with AP and healthy pancreas were compared by two-sample independent t-test. The severity of AP on MRI was classified into subgroups using MR severity index (MRSI), where the mean FA and ADC values were calculated. Relationship among the FA values, ADC values and MRSI were analyzed using Spearman's rank correlation coefficients.ResultsThe pancreatic mean ADC value in the AP group (1.68 ± 0.45×10−3mm2/s) was significantly lower than in the NC group (2.09 ± 0.55×10−3mm2/s) (P = 0.02); the same as mean FA value (0.39 ± 0.23 vs 0.54 ± 0.12, P = 0.00). In the subgroup analysis, the pancreatic ADC and FA value of edema AP patients was significantly higher than necrosis AP patients with P = 0.000 and P = 0.001respectively. In addition, as severity of pancreatitis increased according to MRSI, lower pancreatic ADC (r = -0.635) and FA value (r = -0.654) were noted.ConclusionBoth FA and ADC value from DTI can be used to differentiate AP patients from NC. Both ADC and FA value of pancreas have a negative correlation with the severity of AP.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preliminary Study of MR Diffusion Tensor Imaging of Pancreas for the Diagnosis of Acute Pancreatitis

Zhuang

Zhang

et al. 2016

PLoS ONE

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“…ERCP necessity can adduce continuing inflammation owing to bile duct obstruction, due to impacted stone and this condition can increase the severity of ABP. But despite sphincterotomy performed with ERCP for gallstone in the ABP patients, and cholecystectomy treatment, recurrent pancreatitis may develop due to an unknown etiology 34353640. Even though laparoscopic cholecystectomy is curative when gallbladder stones or sludge are detected, several patients who have undergone cholecystectomy present repeated attacks of pancreatitis 41.…”

Section: Discussionmentioning

confidence: 99%

IL-8 gene polymorphism in acute biliary and non biliary pancreatitis: probable cause of high level parameters?

Anılır

Özen

Yildirim

et al. 2017

Ann Hepatobiliary Pancreat Surg

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Backgrounds/AimsInflammatory mediators of the innate immune response play fundamental roles in the pathogenesis of acute pancreatitis. The correlation between interleukin-8 (IL-8) gene polymorphism with types of acute pancreatitis and severity of pancreatitis, was evaluated in this study.MethodsAccording to the diagnostic criteria, 176 patients with acute pancreatitis were grouped into biliary (n=83) and nonbiliary pancreatitis (n=93). Healthy blood donors (n=100) served as controls. Serum alanine transaminase, aspartate transaminase, total and direct bilirubin, amylase, lypase, white blood cell count and c-reactive protein levels were evaluated to correlate with IL-8 rs4073 (-251T/A) polymorphism, which was analyzed using a real-time polymerase chain reaction method with melting point analysis.ResultsThe IL-8 AA genotype was detected with a significantly higher frequency among the patients with acute biliary pancreatitis having higher alanine transaminase levels than the median range. Homozygote alleles were significantly higher among patients with acute biliary pancreatitis having amylase levels higher than the median range.ConclusionsDetermination of the frequency of IL-8 polymorphism in acute pancreatitis is informative and provides further evidence concerning the role of IL-8 in laboratory tests.

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“…There was an attempt to determine the relationship between the involvement of renal and perirenal space and the severity of acute pancreatitis with magnetic resonance imaging (MRI) (Li et al, 2012). Superparamagnetic iron oxide (SPIO) nanoparticles have been used as cell labeling agent in both preclinical and clinical settings.…”

Section: Introductionmentioning

confidence: 99%

Clodronate-superparamagnetic iron oxide-containing liposomes attenuate renal injury in rats with severe acute pancreatitis

Dang

Zeng

Wang

et al. 2014

J. Zhejiang Univ. Sci. B

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Background and objective: It has been shown that macrophages play an important role in the development of severe acute pancreatitis (SAP), and eventually lead to multiple organ failure (MOF). Clodronate-liposome selectively depleted macrophages. This study was to investigate the role of renal macrophage infiltration in acute renal injury in rats with SAP and to evaluate the potential of superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance imaging (MRI) for diagnosis. Methods: Superparamagnetic Fe 3 O 4 nanoparticles were prepared by chemical coprecipitation. SPIO-liposomes and SPIO-clodronate-liposomes were prepared by the thin film method. SAP models were prepared by injection of sodium taurocholate into the subcapsular space of rat pancreas. Sprague-Dawley rats were randomly divided into a control group, SAP plus SPIO-liposome (P) group, and SAP plus SPIO-clodronatecontaining liposome (T) group. Kidney injury was evaluated by T2-weighted MRI scan. The levels of serum amylase (SAM), blood urea nitrogen (BUN), and serum creatinine (SCr) were measured by an automated enzymatic method. Serum tumor necrosis factor-α (TNF-α) was measured by enzyme-linked immunosorbent assay (ELISA). Pathological changes in the pancreas and kidney were observed using hematoxylin and eosin (H&E) staining, while cell apoptosis was detected with terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining. In addition, the macrophage markers (CD68) of the renal tissue were detected with immunohistochemistry. Results: The pathological changes in the pancreas and kidneys of rats in the T group were milder than those in the P group. The MRI signal intensity of the kidneys in the P and T groups was significantly lower than that in the control group. There were significant changes in the two experimental groups (P<0.01). The levels of SAM, Bun, SCr, and TNF-α in rats in the P group were higher than those in the control group (P<0.01) and in the T group (P<0.01). The apoptosis of the kidney in the T group was higher than that in the P group at 2 and 6 h (P<0.01). Conclusions: Clodronate-containing liposomes protected against renal injury in SAP rats, and SPIO can be used as a tracer for MRI examination to detect renal injury in SAP rats. SPIO-aided MRI provided an efficient non-invasive way to monitor the migration of macrophages after renal injury in rats with SAP.

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Renal and perirenal space involvement in acute pancreatitis: An MRI study

Cited by 13 publications

References 17 publications

Preliminary Study of MR Diffusion Tensor Imaging of Pancreas for the Diagnosis of Acute Pancreatitis

Preliminary Study of MR Diffusion Tensor Imaging of Pancreas for the Diagnosis of Acute Pancreatitis

IL-8 gene polymorphism in acute biliary and non biliary pancreatitis: probable cause of high level parameters?

Clodronate-superparamagnetic iron oxide-containing liposomes attenuate renal injury in rats with severe acute pancreatitis

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