Renal angiomyolipoma: a radiological classification and update on recent developments in diagnosis and management

Jinzaki, Masahiro; Silverman, Stuart G.; Akita, Hirotaka; Nagashima, Yoji; Mikami, Shuji; Oya, Mototsugu

doi:10.1007/s00261-014-0083-3

Cited by 282 publications

(296 citation statements)

References 91 publications

(188 reference statements)

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“…Table 1 shows the radiological characteristics of patients diagnosed with PEComa in a study of 32 cases (4). The table also presents radiological characteristics of AML types (11,12,13). MRI was used as the imaging modality in our case but it failed to provide a definitive preoperative diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Perivascular Epithelioid Cell Tumor of the Kidney: A Rare Case Report

Karakoç¹,

Çelik²,

Bozkurt³

et al. 2017

jus

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IntroductionPerivascular epithelioid cell tumors (PEComas) of the kidney are a group of tumor family covering classical angiomyolipoma (AML), microscopic AML (microhamartoma), intraglomerular lesions, cystic AML, epithelioid AML, oncocytoma-like AML and lymphangiomyomatosis of the renal sinus. The World Health Organization (WHO) defines PEComa as a "mesenchymal tumor that contains perivascular epithelioid cells presenting histological and immunohistochemical differences". While classical AML is benign, epithelioid AMLs are defined as potentially malign mesenchymal lesions for their capacity to develop local recurrence and metastasis (1,2,3). Surgical treatment may be required in AML for symptoms such as hemorrhage and pain, or for the risk of malignancy in tumors that cannot be differentiated from AML in the case of PEComa and certain variants of AML (3,4,5).This case report aimed to present a patient who undergone retroperitoneoscopic partial nephrectomy due to a renal mass and diagnosed with PEComa after pathological examination. Case PresentationWe planned magnetic resonance imaging (MRI) in a 25-year-old male patient, who was admitted to our clinic due to left-sided flank pain, with no pathological finding during the examination and laboratory tests, however, with a suspicious mass lesion located at the inferior pole of the left kidney detected during ultrasonographic examination. It was decided to perform surgical excision after detection of a 4 cm tumoral lesion in the inferior pole of the left kidney on MRI (Figure 1). We performed left retroperitoneoscopic partial nephrectomy in our clinic. The total operative time was 90 minutes with the warm ischemia time Böbreğin perivasküler epiteloid hücre tümörleri nadir görülen histolojik ve immünohistokimyasal olarak farklı perivasküler epiteloid hücrelerden oluşan mezenkimal tümörlerdir. Çoğunluğu benign tümörlerdir; fakat malign olanları agresif seyredebilir ve metastaza yol açabilir. Standart tedavi yöntemi ise cerrahi eksizyondur. Olgumuzda 25 yaşında sol böbrek alt polünde 4 cm kitle saptanan ve cerrahi olarak eksize ettiğimiz hastayı sunmayı amaçladık. Anahtar Kelimeler: Böbrek tümörü, perivasküler epiteloid hücre tümörü, parsiyel nefrektomi Perivascular epithelioid cell tumors are rare mesenchymal tumors composed of histologically and immunohistochemically distinctive perivascular epithelioid cells. They are mostly benign, however, malignant tumors with aggressive behavior and distant metastasis can also occur. The standard treatment is surgical excision. Here, we report a case of a 25-year-old male with a 4 cm-mass located in the inferior pole of the left kidney, treated by surgical excision.

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Section: Discussionmentioning

confidence: 99%

Perivascular Epithelioid Cell Tumor of the Kidney: A Rare Case Report

Karakoç¹,

Çelik²,

Bozkurt³

et al. 2017

jus

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“…Because it is benign in nature, asymptomatic cases can be managed by active surveillance [1,2]. Approximately 60% of patients with large AMLs present with a combination of acute bleeding, flank pain, hematuria, and palpable mass.…”

Section: Discussionmentioning

confidence: 99%

“…Renal AML is an uncommon benign tumor, and approximately 20% cases are associated with the TS complex [1][2][3][4]. Because it is benign in nature, asymptomatic cases can be managed by active surveillance [1,2].…”

Section: Discussionmentioning

confidence: 99%

“…Because AMLs are usually asymptomatic, tumors of >4-cm diameter are usually symptomatic and present with retroperitoneal and/or urinary bleeding, which can be life threatening [1,3,4]. The standard treatment option in symptomatic patients with AML is nephron-sparing surgery [1,2,5]. However, in the past two decades, selective arterial embolization (SAE) has been used as the first-line treatment option in patients presenting with acute bleeding as well as prophylactically to prevent future bleeding complications [3,6].…”

Section: Introductionmentioning

confidence: 99%

“…Approximately 20% of AMLs are associated with the tuberous sclerosis (TS) complex [1,2]. Because AMLs are usually asymptomatic, tumors of >4-cm diameter are usually symptomatic and present with retroperitoneal and/or urinary bleeding, which can be life threatening [1,3,4].…”

Section: Introductionmentioning

confidence: 99%

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Selective Arterial Embolization of Giant Renal Angiomyolipoma Associated with Tuberous Sclerosis Complex Using Particular and Liquid Embolic Agents

Kocakgol

Cayli²,

Oguz

et al. 2018

Eurasian J Med

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Renal angiomyolipoma (AML) is a benign hamartomatous tumor that is sometimes associated with the tuberous sclerosis complex. We report a 23-year-old man who presented with acute abdominal pain and hematuria. Computed tomography (CT) revealed large heterogeneous right renal mass of 17×13×13-cm diameter, consistent with AML, and acute and subacute hemorrhages. Digital subtraction angiography revealed massive tumor vascularization and multiple aneurysms associated with right renal artery branches. First, polyvinyl alcohol particles were used for the selective embolization of AML. Then, N-butyl cyanoacrylate (glue) mixed with lipiodol in a 1:3 ratio was injected for the permanent embolization of AML. CT scan revealed 59% reduction in size at 5 months after embolization. This case illustrates the selective embolization of giant renal AML with the combination of particular and liquid embolic agents with a significant reduction in size during the follow-up period.

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Diagnostic value of imaging in patients with clear cell papillary renal cell carcinoma: A case series and literature review

Song,

Yang,

Zhang

et al. 2024

J of Clinical Ultrasound

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Clear cell papillary renal cell carcinoma (CCPRCC) is a newly classified renal cell carcinoma with a low degree of malignancy. Its imaging features have not been studied deeply. Therefore, we reviewed the imaging features of CCPRCC. Solid CCPRCC shows high echo or isoecho mass on conventional ultrasound. Contrast enhanced ultrasound shows “fast forward and slow backward, uneven high enhancement”. Computed tomography shows high enhancement and maximum enhancement in the cortical‐medullary phase. Magnetic resonance imaging shows slightly low T1WI and high T2WI. This article aims to improve the understanding of CCPRCC by clinical radiologists and promote the accurate.

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Renal angiomyolipoma: a radiological classification and update on recent developments in diagnosis and management

Cited by 282 publications

References 91 publications

Perivascular Epithelioid Cell Tumor of the Kidney: A Rare Case Report

Perivascular Epithelioid Cell Tumor of the Kidney: A Rare Case Report

Selective Arterial Embolization of Giant Renal Angiomyolipoma Associated with Tuberous Sclerosis Complex Using Particular and Liquid Embolic Agents

Diagnostic value of imaging in patients with clear cell papillary renal cell carcinoma: A case series and literature review

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