Renal angiomyolipoma in Japanese tuberous sclerosis patients

Kitano, Yoshihiro; Honna, Toshiro; Nihei, Keiji; Miyauchi, Jun; Matsuoka, Kentarou; Kuroda, Takeshi; Tanaka, Kiyoshi; Morikawa, Nobuyuki; Fuchimoto, Yasushi

doi:10.1016/j.jpedsurg.2004.08.036

Cited by 6 publications

(4 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since its first description by Ishak in 1976, approximately 200 cases have been reported in the English literature 1. This type of tumor is usually seen in kidneys associated with tuberous sclerosis 2. Definite pathologic diagnosis is made by identification of the three different components and HMB-45 positive staining 3…”

Section: Introductionmentioning

confidence: 99%

Management of Hepatic Angiomyolipoma

Yang

Jeng

et al. 2007

Journal of Gastrointestinal Surgery

114

View full text Add to dashboard Cite

Preoperative diagnosis of hepatic angiomyolipoma is difficult, and the treatment for it remains controversial. The aim of this study is to review our experience in the treatment of hepatic angiomyolipoma and to propose a treatment strategy for this disease. We retrospectively collected the clinical, imaging, and pathological features of patients with hepatic angiomyolipoma. Immunohistochemical studies with antibodies for HMB-45, actin, S-100, cytokeratin, vimentin, and c-kit were performed. Treatment experience and long-term follow-up results are summarized. During a period of 9 years, 10 patients with hepatic angiomyolipoma were treated at our hospital. There was marked female predominance (nine patients). Nine patients received surgical resection without complications. One patient received nonoperative management with biopsy and follow-up. One patient died 11 months after surgery because of recurrent disease. We propose all symptomatic patients should receive surgical resection for hepatic angiomyolipoma. Conservative management with close follow-up is suggested in patients with asymptomatic tumors and meet the following criteria: (1) tumor size smaller than 5 cm, (2) angiomyolipoma proved through fine needle aspiration biopsy, (3) patients with good compliance, and (4) not a hepatitis virus carrier.

show abstract

Section: Introductionmentioning

confidence: 99%

Management of Hepatic Angiomyolipoma

Yang

Jeng

et al. 2007

Journal of Gastrointestinal Surgery

114

View full text Add to dashboard Cite

show abstract

“…Similarly, abdominal masses were palpable in 6% and 47%, respectively, and hematuria was noted in 12% and 27%, respectively 26 . Thus, a maximum tumor diameter of 4 cm may be a cut‐off value important for symptom appearance in patients with renal AML 26,27 …”

Section: Methodsmentioning

confidence: 99%

“…26 Thus, a maximum tumor diameter of 4 cm may be a cut-off value important for symptom appearance in patients with renal AML. 26,27 Hatano et al suggested the possibility that renal AML may rupture during pregnancy, promoting awareness. As etiological factors, they indicated the following points: estrogen/progesterone receptors appear on renal AML, and may rapidly increase during pregnancy; on the maternal side, the circulating blood volume increases during pregnancy, elevating the (1) Genetic diagnostic criteria The identification of either a TSC1 or TSC2 pathogenic mutation in DNA from normal tissue is sufficient to make a definite diagnosis of tuberous sclerosis complex.…”

Section: Overviewmentioning

confidence: 99%

Clinical Practice Guidelines for tuberous sclerosis complex‐associated renal angiomyolipoma by the Japanese Urological Association: Summary of the update

et al. 2023

View full text Add to dashboard Cite

New clinical issues have been raised through an interval of 7 years from the previous version (2016). In this study, we update the “Clinical Practice Guidelines for tuberous sclerosis complex‐associated renal angiomyolipoma” as a 2023 version under guidance by the Japanese Urological Association. The present guidelines were cooperatively prepared by the Japanese Urological Association and Japanese Society of Tuberous Sclerosis Complex; committee members belonging to one of the two societies or specializing in the treatment of this disease were selected to prepare the guidelines in accordance with the “Guidance for preparing treatment guidelines” published by Minds (2020 version). The “Introduction” consisted of four sections, “Background Questions (BQ)” consisted of four sections, “Clinical Questions (CQ)” consisted of three sections, and “Future Questions (FQ)” consisted of three sections (total: 14 sections). Concerning CQ, an agreement was confirmed through voting by the committee members based on the direction and strength of recommendation, accuracy of evidence, and recommendation comments. The present guidelines were updated based on the current evidence. We hope that the guidelines will provide guiding principles for the treatment of tuberous sclerosis complex‐associated renal angiomyolipoma to many urologists, becoming a foundation for subsequent updating.

show abstract

“…AML complicating tuberous sclerosis shows a rapid growth and its rupture is frequently associated with hemorrhagic shock as a result of profuse retroperitoneal bleeding, necessitating an aggressive therapeutic approach [1-3]. …”

Section: Introductionmentioning

confidence: 99%

Bilateral renal angiomyolipoma in a patient with tuberous sclerosis treated with resection of one kidney and transarterial embolization of other kidney using CT during selective arteriography: a case report

Katada

Umehara

Ohki

et al. 2009

Cases J

View full text Add to dashboard Cite

Renal AML complicating tuberous sclerosis shows a rapid growth and its rupture is frequently associated with hemorrhagic shock as a result of profuse retroperitoneal bleeding, necessitating an aggressive therapeutic approach. This report describes the long-term clinical progress of 28 year-old woman with tuberous sclerosis with a ruptured giant AML that underwent unilateral nephrectomy, who has been followed up after treatment with concomitant application of computed tomography during selective arteriography to conserve the remaining normal renal parenchyma, and in whom the need for initiation of dialysis has been successfully avoided, with conspicuous reduction of the tumor size.

show abstract

Renal angiomyolipoma in Japanese tuberous sclerosis patients

Cited by 6 publications

References 21 publications

Management of Hepatic Angiomyolipoma

Management of Hepatic Angiomyolipoma

Clinical Practice Guidelines for tuberous sclerosis complex‐associated renal angiomyolipoma by the Japanese Urological Association: Summary of the update

Bilateral renal angiomyolipoma in a patient with tuberous sclerosis treated with resection of one kidney and transarterial embolization of other kidney using CT during selective arteriography: a case report

Contact Info

Product

Resources

About