Renal Artery Stenosis in Childhood Neurofibromatosis

Tilford, David; Kelsch, Robert C.

doi:10.1001/archpedi.1973.02110190537016

Cited by 19 publications

(11 citation statements)

References 20 publications

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“…Riccardi [1] hypothesized an association between hypertension and large plexiform neurofibroma or numerous neurofibromas, explaining this by increased catecholamine production by the neurofibroma. These findings derive from a few studies all based on casual BP measurement [11,18,35,36]. Among our patients, a 16-year-old boy had hypertension and a large cervical plexiform neurofibroma, but he did not have increased urinary catecholamine levels.…”

Section: Discussionmentioning

confidence: 59%

Blood pressure and cardiovascular involvement in children with neurofibromatosis type1

Lama

Graziano

Calabrese

et al. 2004

Pediatric Nephrology

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We evaluated blood pressure in a sample of patients with neurofibromatosis type 1 (NF1), using ambulatory blood pressure monitoring (ABPM), to determine whether ABPM, when compared with casual BP recordings, allowed the detection of a higher risk for hypertension. We also evaluated the correlation between BP and vascular abnormalities. We studied 69 NF1 patients (36 males and 33 females) with a mean age of 11+/-4 years, divided into group A, with 24-h mean systolic blood pressure (SBP) or diastolic blood pressure (DBP) <95th percentile, and group B, with mean SBP or DBP >95th percentile. Standard electrocardiography and M-mode, two-dimensional echocardiography were performed and all patients were in sinus rhythm. ABPM identified 11 hypertensive patients (16%); 5 had a mean SBP >95th percentile, 3 mean SBP-DBP >95th percentile, and 3 a mean DBP >95th percentile. Laboratory and other investigations to exclude secondary hypertension were normal. Cardiac abnormalities were found in 13 of the 69 patients (18.8%) with NF1. There were no significant clinical and cardiac differences between the normotensive and hypertensive group. Our data emphasize the importance of periodic ABPM in NF1 patients to diagnose hypertension early and avoid target organ damage and increased mortality.

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Section: Discussionmentioning

confidence: 59%

Blood pressure and cardiovascular involvement in children with neurofibromatosis type1

Lama

Graziano

Calabrese

et al. 2004

Pediatric Nephrology

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“…For these two reasons, we could neither biopsy nor resect the tumors. Since renovascular hypertension in neurofibromatosis was first reported in 1952 [6], approximately 100 cases have been reported: Tilfford et al [7] and Elias et al [8] described these patients and the relevant literature. In Japan, since the first report in 1973 [9], 9 cases were reported including the present case (table 5) [10][11][12][13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

A Case of Renovascular Hypertension Associated with Neurofibromatosis

Hirayama

Kobayashi

Yamaguchi

et al. 1996

Nephron

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We report a case of renovascular hypertension associated with neurofibromatosis complicated by moderate proteinuria. A 16-year-old female was admitted to Kensei General Hospital with a complaint of headache and a blood pressure of 230/120 mm Hg. She was referred to us for further evaluation of the hypertension. On examination, cafe-au-lait spots were seen over her extremities and flank, and a bruit was heard in the right upper abdomen. The urinary protein excretion was 2.1 g/day. The plasma renin activity (PRA) and plasma aldosterone concentration were high, but the levels of catecholamines were normal. The renogram was asymmetric and on venous sampling, the PRA in the right renal vein was 58.3 ng/ml/h and that in the left was 22.1 ng/ml/h. CT scan detected an approximately 10-mm mass in the proximal right renal artery. Arteriography disclosed severe stenosis in the right renal artery and the superior mesenteric artery. Therefore, we concluded that her hypertension resulted from stenosis of the right renal artery due to neurofibromatosis. Accordingly, she underwent an operation to reconstruct that artery. After the operation, her blood pressure and PRA normalized without administration of any anti-hypertensive drug and urinary protein disappeared.

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“…Pheo chromocytoma is the more frequent cause of hyperten sion in neurofibromatosis patients over 18 years of age. Renal artery stenosis is 7 times more likely than pheo chromocytoma in the group under 18 years of age and is the only cause of hypertension under 12 years of age [6], From the literature we collected 102 cases of renovascu lar hypertension in neurofibromatosis including 7 Japa nese cases. The patients were between 1 and 46 years old, with a mean age of 13.9 years.…”

Section: Discussionmentioning

confidence: 99%

Neurofibromatosis Associated with Renovascular Hypertension due to Stenosis and Aneurysm of the Left Renal Segmental Artery: Report of a Case

Kuo

Okada²,

Takeuchi³

et al. 1989

Urol Int

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We report a case of renovascular hypertension due to renal segmental artery stenosis and aneurysm seen in a 16-year-old boy with neurofibromatosis. Hypertension was successfully treated with partial nephrectomy. Histopathologic examination disclosed proliferation of arterial intima not only in the stenotic portion and the aneurysm but also in intralobular arteries of the kidney. Review of the literature revealed that treatment for such patients has varied.

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Renal Artery Stenosis in Childhood Neurofibromatosis

Cited by 19 publications

References 20 publications

Blood pressure and cardiovascular involvement in children with neurofibromatosis type1

Blood pressure and cardiovascular involvement in children with neurofibromatosis type1

A Case of Renovascular Hypertension Associated with Neurofibromatosis

Neurofibromatosis Associated with Renovascular Hypertension due to Stenosis and Aneurysm of the Left Renal Segmental Artery: Report of a Case

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