Renal Aspergilloma Due to Aspergillus flavus

Khan, Zia U.; Gopalakrishnan, Ganesh; Al-Awadi, Khaleel A.; Gupta, Ram Kumar; Moussa, Sami A.; Chugh, T.D.; Krajčí, D

doi:10.1093/clinids/21.1.210

Cited by 20 publications

(14 citation statements)

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“…flavus has been reported as a cause of both native and prosthetic valve endocarditis, which is occasionally a manifestation of disseminated aspergillosis (Demaria et al, 2000;Rao & Saha, 2000;Irles et al, 2004). Occasional cases occur in patients with no overt risk factors (Kennedy et al, 1998;Khan et al, 1995). In postoperative Aspergillus endocarditis, A. flavus accounts for 11.2 % of cases (Pasqualotto & Denning, 2006).…”

Section: Endocarditis and Pericarditismentioning

confidence: 99%

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Aspergillus flavus: human pathogen, allergen and mycotoxin producer

et al. 2007

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Aspergillus infections have grown in importance in the last years. However, most of the studies have focused on Aspergillus fumigatus, the most prevalent species in the genus. In certain locales and hospitals, Aspergillus flavus is more common in air than A. fumigatus, for unclear reasons. After A. fumigatus, A. flavus is the second leading cause of invasive aspergillosis and it is the most common cause of superficial infection. Experimental invasive infections in mice show A. flavus to be 100-fold more virulent than A. fumigatus in terms of inoculum required. Particularly common clinical syndromes associated with A. flavus include chronic granulomatous sinusitis, keratitis, cutaneous aspergillosis, wound infections and osteomyelitis following trauma and inoculation. Outbreaks associated with A. flavus appear to be associated with single or closely related strains, in contrast to those associated with A. fumigatus. In addition, A. flavus produces aflatoxins, the most toxic and potent hepatocarcinogenic natural compounds ever characterized. Accurate species identification within Aspergillus flavus complex remains difficult due to overlapping morphological and biochemical characteristics, and much taxonomic and population genetics work is necessary to better understand the species and related species. The flavus complex currently includes 23 species or varieties, including two sexual species, Petromyces alliaceus and P. albertensis. The genome of the highly related Aspergillus oryzae is completed and available; that of A. flavus in the final stages of annotation. Our understanding of A. flavus lags far behind that of A. fumigatus. Studies of the genomics, taxonomy, population genetics, pathogenicity, allergenicity and antifungal susceptibility of A. flavus are all required.

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Section: Endocarditis and Pericarditismentioning

confidence: 99%

“…Urinary tract aspergillosis due to A. flavus is rare, with few cases reported (Khan et al, 1995;Perez-Arellano et al, 2001;Kueter et al, 2002). Usually a unilateral or bilateral fungal bezoar of the urinary pelvis is the presenting problem.…”

Section: Urinary Tract Infectionmentioning

confidence: 99%

Aspergillus flavus: human pathogen, allergen and mycotoxin producer

et al. 2007

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“…Haq et al (2007) described a case of localized renal aspergillosis in diabetic patients, Washawasky et al (1975) and Godec et al (1989) reported few cases of renal aspergillosis, while 7 cases were reported in the present study. Urinary tract aspergillosis due to A. flavus is rare with few reported cases (Khan et al, 1995;Perez-Arellano et al, 2001 andKueter et al, 2002) as we isolated 5 cases of A. falvus in this study.…”

Section: Discussionmentioning

confidence: 70%

Detection of Aflatoxin in AspergillusSpecies Isolated from Immunocompromised Hospitalized Patients

2015

Egypt. J. Microbiol.

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SPERGILLUS infections have grown in importance in the last few decades. However, most of the studies have focused on Aspergillus fumigatus, the most prevalent species in the human infections which is followed by Aspergillus flavus . Eventhough Aspergillus flavus was more common than A. fumigatus in some reports. Aspergillus niger came next to them causing invasive aspergillosis . Aspergillus flavus is a widely feared fungal pathogen capable of producing aflatoxin, the most potent mycotoxin . Two hundred and fifty hospitalized patients were studied for fungal infection. Out of the collected cases 109 were positive fungal infection representing 43.6% of the total cases. The age of the patients ranged from 22 to 68 years, of which 61% were male and 39% were female. Three species of the genus Aspergillus were collected from 18 cases representing 16.5% of the total positive. These isolates identified as Aspergillus flavus (11 cases ) followed by A .niger (5 cases ) and A. fumigatus ( 2 cases ) representing 10.1%, 4.6% and 1.8% , respectively. Identification was carried out using the traditional method and confirmed by the molecular techniques (amplification of the internal transcribed spacer 2 (ITS2) region and direct sequencing followed by comparative GenBank analysis ). All the isolates were tested for aflatoxin production using High Performance Liquid Chromatography (HPLC). Aflatoxins B1 and B2 were produced from A. flavus only while A. niger and A. fumigatus were non-producers. Voriconazole (200 mg/12h for 12 weeks) and Micafungin (100-150 mg/day for 12 weeks) were successfully used for treating all the cases.

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“…16,17 In the second, an immunodepressed status caused by several conditions such as malignant hemopathies, 18,19 transplants, 20,21 (including kidneys from donors, 22,23 ), AIDS, 24,25 and longstanding steroid therapy 26 has been also reported. 16,17 In the second, an immunodepressed status caused by several conditions such as malignant hemopathies, 18,19 transplants, 20,21 (including kidneys from donors, 22,23 ), AIDS, 24,25 and longstanding steroid therapy 26 has been also reported.…”

Section: Discussionmentioning

confidence: 99%