2024
DOI: 10.1038/s41598-024-64484-9
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Renal autocrine neuropeptide FF (NPFF) signaling regulates blood pressure

Hewang Lee,
Bibhas Amatya,
Van Anthony M. Villar
et al.

Abstract: The kidney and brain play critical roles in the regulation of blood pressure. Neuropeptide FF (NPFF), originally isolated from the bovine brain, has been suggested to contribute to the pathogenesis of hypertension. However, the roles of NPFF and its receptors, NPFF-R1 and NPFF-R2, in the regulation of blood pressure, via the kidney, are not known. In this study, we found that the transcripts and proteins of NPFF and its receptors, NPFF-R1 and NPFF-R2, were expressed in mouse and human renal proximal tubules (R… Show more

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