Renal Behçet's Disease: An Update

Tekin, Mustafa; Dilek, Melda; Aksu, Kenan; Keser, Gökhan; Toprak, Ömer; Ci̇ri̇t, Mustafa; Oğuz, Yusuf; Taşkapan, Hülya; Adibelli̇, Zelal; Akar, Harun; Tokgöz, Bülent; Arıcı, Mustafa; Çeli̇ker, Hüseyin; Di̇ri̇, Banu; Akpolat, İlkser

doi:10.1016/j.semarthrit.2007.11.001

Cited by 53 publications

(55 citation statements)

References 37 publications

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“…6 BD-related amyloidosis is more common in Mediterranean countries, and in Turkey, it accounts for 3.6% of secondary amyloidosis, although some of these patients may have Familial Mediterranean fever mutations. 7 Akpolat et al 8 have published one of the largest series, with 33 patients diagnosed with BD and renal involvement. Of these, 11 patients present AA amyloidosis and, unlike our case, almost 90% are males.…”

Section: Discussionmentioning

confidence: 99%

Tocilizumab Treatment for Nephrotic Syndrome Due to Amyloidosis in Behcet’s Disease

et al. 2013

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Renal involvement is an unusual but significant Behcet´s disease (BD) complication and AA amyloidosis appears to be the most common etiology. IL-6 is a pro-inflammatory cytokine with an important role in AA amyloidosis development. Tocilizumab (TCZ) is a humanized anti-IL-6 receptor antibody that has emerged as an effective and specific treatment in AA amyloidosis secondary to chronic inflammatory disorders. We report on a patient diagnosed with BD who developed nephrotic syndrome caused by renal AA amyloidosis with an excellent response to TCZ therapy.

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Section: Discussionmentioning

confidence: 99%

Tocilizumab Treatment for Nephrotic Syndrome Due to Amyloidosis in Behcet’s Disease

et al. 2013

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“…The first presentation is often incidentally found proteinuria or haematuria caused by glomerulonephritis [7][8][9]. Crescenteric and proliferative glomerulonephritis, as well as IgA nephritis, have also been reported in some cases [7,8,10,11]. Moreover, nephrotic syndrome might be present in over 83% of patients with amyloidosis, and renal failure is common at the time of diagnosis [7,8,10].…”

Section: Discussionmentioning

confidence: 99%

A severe renal bleeding as a complication of coumarin therapy in Behçet's disease

Remková

Milatová²,

Fuchsbergerová³

2010

Blood Coagulation &Amp; Fibrinolysis

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Behçet's disease is a systemic inflammatory disease, which predisposes patients to venous or arterial thrombosis. We report a case of 41-year-old patient who presented for several years with recurrent fevers, arthralgias, episodes of skin eruptions and recurrent bilateral deep venous ileofemoral thromboses, extending into the inferior vena cava, despite the oral anticoagulant therapy. Additionally, he also reported recurrent aphthous oral and genital lesions, and eye problems. A laboratory picture of chronic inflammation, normocytic anaemia and a finding of lupus anticoagulant/antiphospholipid antibodies were observed. PET raised a high suspicion of vasculitic PTT-lupus anticoagulant process, involving the large vessels. During an anticoagulant therapy by warfarin (dose in upper limit of therapeutic range), the left kidney had to be removed because of acute retroperitoneal haemorrhage. On histologic examination, the picture of nephritis was described. A detailed retrospective reevaluation of complex history as well as other clinical findings strongly raised the suspicion of a systemic vasculitic syndrome, such as Behçet's disease, accompanied by antiphospholipid syndrome. The patient responded well to the combination of colchicine and anticoagulant therapy by low-molecular-weight heparin. The episodes of fever, skin eruptions and other symptoms disappeared. We assume that this is a case of an unusual course of Behçet's disease presenting with a rare kidney involvement. Kidney disorder complicated the oral anticoagulant therapy for recurrent venous thromboses and led to the excessive renal bleeding, requiring nephrectomy. Recognition that nephritis is associated with Behçet's disease may be useful to prevent severe renal bleeding in relation to anticoagulant therapy.

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“…Amyloidosis in Behçet's disease is usually associated with renal failure and patients with amyloidosis have a five-year survival of 46%. 13 Male sex, prolonged disease duration, recurrent arthritis, multiple systemic involvement and peripheral vessel or pulmonary artery involvement were important predictors of amyloidosis. 9 Our patient also had vascular and arthritic involvement.…”

Section: Case Reportmentioning

confidence: 98%

A Case with Sjogren’s Syndrome and Behçet’s Disease Developing Secondary Amyloidosis

Erten¹,

İnal²,

Percinel³

et al. 2012

Turkiye Klinikleri J Med Sci

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Renal Behçet's Disease: An Update

Cited by 53 publications

References 37 publications

Tocilizumab Treatment for Nephrotic Syndrome Due to Amyloidosis in Behcet’s Disease

Tocilizumab Treatment for Nephrotic Syndrome Due to Amyloidosis in Behcet’s Disease

A severe renal bleeding as a complication of coumarin therapy in Behçet's disease

A Case with Sjogren’s Syndrome and Behçet’s Disease Developing Secondary Amyloidosis

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