Renal biomarkers in cats: A review of the current status in chronic kidney disease

Kongtasai, Thirawut; Paepe, Dominique; Meyer, Evelyne; Mortier, Femke; Marynissen, Sofie; Stammeleer, Lisa; Defauw, Pieter; Daminet, Sylvie

doi:10.1111/jvim.16377

Cited by 20 publications

(23 citation statements)

References 248 publications

(759 reference statements)

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“…Serum Cystatin C ist ein niedermolekulares Protein (13 kDa), das kontinuierlich von allen kernhaltigen Zellen produziert wird. Es ist nicht proteingebunden, wird frei glomerulär filtriert und anschließend im proximalen Tubulus reabsorbiert und katabolisiert 20 . Es ist ein nützlicher Faktor zur Evaluation der GFR in der Humanmedizin.…”

Section: Renale Biomarker – Welche Sind Hilfreich?unclassified

Früherkennung der chronischen Nierenerkrankung bei der Katze

Eichberger,

Guntermann,

Rolinger

2023

veterinär spiegel

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Section: Renale Biomarker – Welche Sind Hilfreich?unclassified

Früherkennung der chronischen Nierenerkrankung bei der Katze

Eichberger,

Guntermann,

Rolinger

2023

veterinär spiegel

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“…Хронічна хвороба нирок (ХХН) у котів -це тривалий процес, що характеризується незворотною втратою метаболічної, ендокринної та екскреторної функцій нирок, як правило, внаслідок розвитку нефросклерозу. Загальна поширеність хронічної хвороби нирок у котів становить приблизно від 2 % до 4 % і зростає до 30-40 % у котів старших 10 років та посідає друге місце серед основних причин їх смерті Brown et al, 2016;Holovakha et al, 2020;Kongtasai et al, 2022).…”

Section: вступunclassified

“…Проте вироблення і метаболізм симетричного диметиларгініну (СДМА) може бути змінений дисфункцією щитовидної залози незалежно від швидкості клубочкової фільтрації (Peterson et al, 2019;Ostrovs'kyj & Slivins'ka, 2021;Kongtasai et al, 2022).…”

Section: вступunclassified

Prevalence and features of early diagnosis of chronic kidney disease in cats

Ostrovskyi,

Slivinska

2023

SMLNUVMB

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Chronic kidney disease (CKD) in cats is a long-term process characterized by the irreversible loss of metabolic, endocrine, and excretory functions of the kidneys, usually due to the development of nephrosclerosis. The overall prevalence of CKD in cats is approximately 2 % to 4 % and increases to 30–40 % in cats older than 10 years. It is the second leading cause of death. CKD can occur due to polycystic disease, pyelonephritis, glomerulonephritis, neoplasia, amyloidosis, viral infections, urolithiasis and is the most common cause of hypertension in cats, accounting for 20 to 60 % of cases. Cats often have a combined course of hyperthyroidism and CKD. For CKD in cats, hyporexia (64.8 %), polyuria and polydipsia (56.7 %), anemia of mucous membranes (67.5 %), impaired coordination of movements (35 %), vomiting (43 %), ulcerative stomatitis were most often noted (37.8 %). Polyuria, polydipsia, polyphagia, nausea, and vomiting were detected in cats with combined course of hyperthyroidism. It was established that the 1st stage of CKD passes without pronounced changes in the blood serum but with the preservation of the symptoms of the disease. The concentration of cystatin C in the blood serum of cats with impaired kidney function at all stages was higher (P > 0.001) compared to clinically healthy animals by 13.9, 34.7, and 73.6 %. In cats at II-IV stages, a significant increase in azotemia was established, accompanied by an increase in creatinine and urea content (P > 0.001) compared to clinically healthy animals. A clear tendency to decrease the rate of glomerular filtration was established at different stages of CKD: at II – 115.8 ± 1.43 ml/min/1.73; the third – 101.7 ± 1.02; IV – 83.9 ± 1.20 ml/min/1.73. The level of SDMA in the blood serum of cats was higher (P < 0.001) in stage II (21.30 ± 0.64 μg/dl), III (30.96 ± 1.17 μg/dl), and IV (91.87 ± 12.54 μg/dL) compared to the control group. A violation of mineral and bone metabolism was established, even in the early stages of the disease, which was characterized by a decrease (Р < 0.001) in the level of total calcium and an increase in the level of inorganic phosphorus and potassium in the blood serum of cats. In the combined course of CKD and hyperthyroidism, an increase (Р < 0.001) in the level of the total hormone T4 in blood serum was found in diseased cats in stages II and IV. Arterial hypertension was established in 16 cats, the risk of which increased from moderate (148 ± 4.7/98 ± 3.8 mmHg at the II stage of the course) to high at the IV stage (188 ± 3.8 mmHg. and 116.7 ± 4.06 mm Hg). The development of anemic syndrome, microcytic hyperchromic anemia, and changes in the physical properties and chemical composition of urine were established.

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“…A detailed review of these markers is available elsewhere. 5 Major oxidative stress markers, such as 8-hydroxy-2 ′deoxyguanosine and malondialdehyde (MDA), have been evaluated in human patients with CKD. One of the oxidative products of DNA, 8-OHdG, is also a sensitive biomarker of oxidative stress that reflects oxidative DNA damage.…”

Section: Introductionmentioning

confidence: 99%

8-Hydroxy-2′-deoxyguanosine and malondialdehyde in plasma and their association with disease severity in 20 cats with chronic kidney disease

Nishi

Harada

Hori

et al. 2023

Journal of Feline Medicine and Surgery

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Objectives Oxidative stress is associated with the development and progression of chronic kidney disease (CKD) in humans. The aim of this study was to evaluate the concentrations of oxidative stress markers, 8-hydroxy-2′-deoxyguanosine (8-OHdG) and malondialdehyde (MDA), in the plasma and urine of cats with different stages of CKD. Methods Plasma and urine samples were collected from cats with CKD that were referred to the Veterinary Medical Center of the University of Tokyo between April 2019 and October 2022. Plasma and urine samples were collected from healthy cats (n = 6 at most), cats with stage 2 CKD (n = 8) and stage 3–4 CKD (n = 12), and cats with idiopathic cystitis (disease control, n = 5). Plasma and urine concentrations of 8-OHdG and MDA were measured using ELISA and thiobarbituric acid reactive substances assay kits, respectively. Results The median plasma 8-OHdG concentrations were 0.156 ng/ml (<0.125–0.210 ng/ml) in the healthy group, <0.125 ng/ml (range <0.125 ng/ml) in the idiopathic cystitis group, 0.246 ng/ml (range 0.170–0.403 ng/ml) in cats with stage 2 CKD and 0.433 ng/ml (range 0.209–1.052 ng/ml) in cats with stage 3–4 CKD. Concentrations in stage 3–4 CKD were significantly higher than those in the healthy and disease control groups. Plasma MDA concentrations were low in the healthy and disease control groups and significantly higher in cats with stage 3–4 CKD. In every cat with CKD, plasma 8-OHdG and MDA concentrations were positively correlated with plasma creatinine concentrations (8-OHdG, rs = 0.68; MDA, rs = 0.67). Urinary 8-OHdG/urinary creatinine (u-CRE) and urinary MDA/u-CRE levels did not differ significantly between the groups; however, it was difficult to evaluate them because of the small sample size. Conclusions and relevance This report shows that plasma 8-OHdG and MDA concentrations increase with the severity of feline CKD. These markers may be useful for assessing oxidative stress in cats with CKD.

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Renal biomarkers in cats: A review of the current status in chronic kidney disease

Cited by 20 publications

References 248 publications

Früherkennung der chronischen Nierenerkrankung bei der Katze

Früherkennung der chronischen Nierenerkrankung bei der Katze

Prevalence and features of early diagnosis of chronic kidney disease in cats

8-Hydroxy-2′-deoxyguanosine and malondialdehyde in plasma and their association with disease severity in 20 cats with chronic kidney disease

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