Renal Biopsy Findings in Acute Renal Failure in the Cohort of Patients in the Spanish Registry of Glomerulonephritis

López‐Gómez, Juan M.; Rivera, Francisco

doi:10.2215/cjn.04441007

Cited by 62 publications

(52 citation statements)

References 31 publications

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“…The high frequency of this crescentic GN was also reported in multiple additional studies on the elderly (3,9,14,18,20), and by Haas et al (4), who found that pauciimmune GN was the cause of AKI in 27% of patients over 80 yr old. Our series also found pauci-immune GN in 10% of patients presenting with chronic-progressive renal failure, similar to a previous study by Ferro et al (5).…”

Section: Discussionsupporting

confidence: 66%

“…Other studies regarding renal biopsies in the elderly included patients over 60 or 65 yr old; in most of the studies (4,5,14,16 -19), nephrotic proteinuria was the most common indication for renal biopsy, followed by AKI (including acute nephritic syndrome). In a recent report from the Spanish Registry of GN (20), AKI was the most frequent indication for renal biopsy in the elderly if AKI and acute nephritic syndrome were included in the same group. Nevertheless, it has been stated that renal biopsy in elderly patients presenting with AKI may not be required in most patients (21).…”

Section: Discussionmentioning

confidence: 99%

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Renal Biopsy in the Very Elderly

Moutzouris¹,

Herlitz²,

Appel³

et al. 2009

Clinical Journal of the American Society of Nephrology

141

140

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Background and objectives: Data regarding renal biopsy in the very elderly (>age 80 yr) are extremely limited. The aim of this study was to examine the causes of renal disease and their clinical presentations in very elderly patients who underwent native renal biopsy.Design, setting, participants, & measurements: All native renal biopsies (n ‫؍‬ 235 including 106 men, 129 women) performed in patients aged >80 yr over a 3.67-yr period were retrospectively identified. Results were compared with a control group of 264 patients aged 60 to 61 who were biopsied over the same period.Results: The indications for biopsy were acute kidney injury (AKI) in 46.4%, chronic-progressive kidney injury in 23.8%, nephrotic syndrome (NS) in 13.2%, NS with AKI in 9.4%, and isolated proteinuria in 5.5%. Pauci-immune GN was the most frequent diagnosis (19%), followed by focal segmental glomerulosclerosis secondary to hypertension (7.6%), hypertensive nephrosclerosis (7.1%), IgA nephropathy (7.1%) and membranous nephropathy (7.1%). Comparison with the control group showed pauci-immune GN to be more frequent (P < 0.001) and diabetic glomerulosclerosis (P < 0.001) and membranous nephropathy (P < 0.05) less frequent in the very elderly. Diagnostic information had the potential to modify treatment in 67% of biopsies from the very elderly, particularly in those with AKI or NS.Conclusions: Renal biopsy in very elderly patients is a valuable diagnostic tool that should be offered in clinical settings with maximal potential benefit. Advanced age per se should no longer be considered a contraindication to renal biopsy.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Renal Biopsy in the Very Elderly

Moutzouris¹,

Herlitz²,

Appel³

et al. 2009

Clinical Journal of the American Society of Nephrology

141

140

View full text Add to dashboard Cite

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“…These data are consistent with most studies in patients over 65 years [5,[15][16][17], in which membranous nephropathy is the most common diagnosis, followed by amyloidosis and MCD, with a markedly lower frequency. As abovementioned it has been also reported relatively high frequencies of FSGS in nephrotic patients over 65 years [18,19].…”

Section: Discussionsupporting

confidence: 92%

“…In a previous study of the same age group [6], AKI was the second most frequent clinical presentation after NS; however, in that study, acute nephritic syndrome and rapidly progressive renal failure were classified separately, while in our present analysis these groups were classified as AKI. Other studies regarding renal biopsies in the elderly included patients over 60 or 65 years; in most of those studies [11][12][13][14][15][16], nephrotic proteinuria was the most common indication for renal biopsy, followed by AKI. Lopez-Gomez et al [15], in a Spanish Registry of GN, reported that AKI was the most frequent biopsy indication in the elderly when AKI and acute nephritic syndrome were included in the same clinical presentation group.…”

Section: Discussionmentioning

confidence: 99%

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Kidney Biopsy Patterns in a Brazilian Elderly Population

Marujo¹,

Romero²,

Moscoso-Solorzano³

et al. 2012

UCMS

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Background:The elderly population is increasing all over the world. Several chronic diseases are observed in such aging group, including kidney diseases, and their histological patterns are not widely documented. Methods: We retrospectively reviewed native kidney biopsies (bx) evaluated in the Department of Pathology of the Federal University of Sao Paulo from 2000 to 2005, selecting 222 of patients > 65 years (ys); 128 bx had diagnosis of glomerulonephritis (GN), and 94 of renal tumors. Results: Fifty-five per cent of the patients were males, and median age was 70 ± 5 ys (range 65-90). The most frequent bx indication was hematuria (50%), followed by acute kidney injury (AKI) (20%), nephrotic syndrome (NS) (19%) and non nephrotic proteinuria (11%). Among patients with GN, mean age was 69 ± 5 ys, and 74/128, males; main bx indications were AKI (35%) and NS (33%), without statistical differences between genders for all clinical presentations. Conclusion: In this study, it was reinforced the important role of renal biopsy in elderly patients, defining main histological patterns of glomerulopathies (membranous nephropathy, amyloidosis) and other renal diseases in this age range in a Brazilian population. Besides being a useful tool for diagnosis, kidney biopsy certainly contributes to the best management of such patients.

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Acute Tubulointerstitial Nephritis

Muthuppalaniappan

Ball

2022

Primer on Nephrology

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Renal Biopsy Findings in Acute Renal Failure in the Cohort of Patients in the Spanish Registry of Glomerulonephritis

Cited by 62 publications

References 31 publications

Renal Biopsy in the Very Elderly

Renal Biopsy in the Very Elderly

Kidney Biopsy Patterns in a Brazilian Elderly Population

Acute Tubulointerstitial Nephritis

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