Renal Biopsy Interpretation

Amoueian, Sakineh; Attaranzadeh, Armin

doi:10.5772/26316

Cited by 4 publications

(4 citation statements)

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“…There is a question of how many glomeruli, tubules, and vessels are necessary for an accurate diagnosis of kidney disease. When diffuse glomerular diseases such as amyloidosis and membranous glomerulonephropathy are suspected, one glomerulus is theoretically sufficient for diagnosis [ 12 , 13 ]. Some researchers insist on a minimum of two tissue cores [ 12 , 14 ], whereas others have said that at least 25 glomeruli are needed for most accurate diagnoses [ 13 , 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…When diffuse glomerular diseases such as amyloidosis and membranous glomerulonephropathy are suspected, one glomerulus is theoretically sufficient for diagnosis [ 12 , 13 ]. Some researchers insist on a minimum of two tissue cores [ 12 , 14 ], whereas others have said that at least 25 glomeruli are needed for most accurate diagnoses [ 13 , 15 , 16 ]. Considering the random distribution of focal glomerular diseases, many more glomeruli are needed.…”

Section: Discussionmentioning

confidence: 99%

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Safety and tissue yield for percutaneous native kidney biopsy according to practitioner and ultrasound technique

et al. 2014

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BackgroundAlthough percutaneous renal biopsy remains an essential tool in the diagnosis and treatment of renal diseases, in recent times the traditional procedure of nephrologists has been performed by non-nephrologists rather than nephrologists at many institutions. The present study assessed the safety and adequacy of tissue yield during percutaneous renal biopsy according to practitioners and techniques based on ultrasound.MethodsThis study included 658 native renal biopsies performed from 2005 to 2010 at a single centre. The biopsies were performed by nephrologists or expert ultrasound radiologists using the ultrasound-marked blind or real-time ultrasound-guided techniques.ResultsA total of 271 ultrasound-marked blind biopsies were performed by nephrologists, 170 real-time ultrasound-guided biopsies were performed by nephrologists, and 217 real-time ultrasound-guided biopsies were performed by radiologists during the study period. No differences in post-biopsy complications such as haematoma, need for transfusion and intervention, gross haematuria, pain, or infection were observed among groups. Glomerular numbers of renal specimens from biopsies performed by nephrologists without reference to any technique were higher than those obtained from real-time ultrasound-guided biopsies performed by expert ultrasound radiologists.ConclusionsPercutaneous renal biopsy performed by nephrologists was not inferior to that performed by expert ultrasound radiologists as related to specimen yield and post-biopsy complications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Safety and tissue yield for percutaneous native kidney biopsy according to practitioner and ultrasound technique

et al. 2014

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“…While adequate tissue supply is important for optimal histomorphological evaluation in patients with renal biopsy indication, how much of the removed tissue should represent the cortex versus the medulla and how many glomeruli and arteries should be in biopsy samples is not agreed upon. In addition to studies reporting that 1 glomerulus is adequate for the diagnosis of amyloidosis or membranous glomerulonephritis 8,9 , there are also studies suggesting that at least 25 glomeruli should be present for the exclusion of focal diseases 9,21,22 . Some researchers think that at least 2 core kidney biopsies should be taken [8][9][10] , as even if the disease can be diagnosed with 1 glomerulus, more kidney tissue is needed to reveal the spread and whether other glomerular pathologies are present and to examine signs of chronicity in the tubulointerstitial compartment and vascular structures.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to studies reporting that 1 glomerulus is adequate for the diagnosis of amyloidosis or membranous glomerulonephritis 8,9 , there are also studies suggesting that at least 25 glomeruli should be present for the exclusion of focal diseases 9,21,22 . Some researchers think that at least 2 core kidney biopsies should be taken [8][9][10] , as even if the disease can be diagnosed with 1 glomerulus, more kidney tissue is needed to reveal the spread and whether other glomerular pathologies are present and to examine signs of chronicity in the tubulointerstitial compartment and vascular structures. At our center, a minimum of 2 and a maximum of 4 core kidney biopsies are taken.…”

Section: Discussionmentioning

confidence: 99%

How does the presence of the pathologist affect the tissue adequacy and what are the factors affecting the pathologist in proficiency assessment, during percutaneous kidney biopsy?

KAYA

Şenol

Dursun

et al. 2023

CMJ

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Objectives: For optimal histomorphological examination, adequacy of kidney biopsy tissue should be obtained. In this study, the effect of a pathologist informing the radiologist about tissue adequacy during the biopsy procedure on obtaining tissue adequacy was examined. Furthermore, we aimed to determine the criteria that the pathologist considered in determining tissue adequacy and the conditions affecting the decision to increase the number of core biopsies, as these have not been previously examined in the literature. Materials and Methods: Tissues containing less than 10 glomeruli were considered inadequate. In some patients, a pathologist accompanied the radiologist during the procedure. Tissue adequacy ratios and biopsy sample numbers were calculated between the two conditions. In the samples taken with the pathologist, the factors affecting the locality decision of the pathologist (cortex/medulla amount, presence of glomerular pathology(global, segmental, crescentic glomeruli) presence of tubular injury, proteinuria; interstitial inflammation and interstitial fibrosis/tubular atrophy ratios, account of normal glomeruli) were examined. Results: Giving tissue adequacy information during the biopsy procedure had a positive effect on tissue adequacy. The amount of cortex is one of the qualification criteria for the pathologist. The presence of proteinuria and 50% or more inflammation in tissues with sufficient cortex increased the number of biopsy samples. Conclusion: Determination of tissue adequacy during kidney biopsy is an important and necessary method. The amount of cortex is one of the important parameters in tissue adequacy.

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Semi-Supervised Segmentation of Renal Pathology: An Alternative to Manual Segmentation and Input to Deep Learning Training

Kline

Chung

Rahmani

et al. 2021

2021 43rd Annual International Conference of the IEEE Engineering in Medicine &Amp; Biology Society (EMBC)

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Renal Biopsy Interpretation

Cited by 4 publications

References 57 publications

Safety and tissue yield for percutaneous native kidney biopsy according to practitioner and ultrasound technique

Safety and tissue yield for percutaneous native kidney biopsy according to practitioner and ultrasound technique

How does the presence of the pathologist affect the tissue adequacy and what are the factors affecting the pathologist in proficiency assessment, during percutaneous kidney biopsy?

Semi-Supervised Segmentation of Renal Pathology: An Alternative to Manual Segmentation and Input to Deep Learning Training

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