Renal Blood Flow and Renin Activity in Renal Venous Blood in Essential Hypertension

Blaufox, M. Donald; Fromowitz, Arthur J.; Lee, Hyo Bok; Meng, Chien-Hsing; Elkin, Milton

doi:10.1161/01.res.27.6.913

Cited by 41 publications

(10 citation statements)

References 20 publications

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“…Also, Hollenberg et al (12) and Blaufox and coworkers (13) have demonstrated superficial redistribution of blood flow in human subjects on high salt diets using the krypton washout technique.…”

Section: Introductionmentioning

confidence: 99%

“…The only previous experiments on blood flow distribution during dietary variations in salt load have been those of Hollenberg and coworkers (12) and Blaufox et al (13), both of whom demonstrated a superficial redistribution of blood flow on high salt as compared with low salt diets. These studies were performed in human subjects using inert gas washout techniques.…”

mentioning

confidence: 99%

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Effect of variation in dietary NaCl intake on the intrarenal distribution of plasma flow in the rat

Blantz¹,

Wallin²,

Rector³

et al. 1972

J. Clin. Invest.

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A B S T R A C T The effect of dietary variation in sodium chloride intake on the intrarenal distribution of plasma flow was investigated in rats using the antiglomerular base~ment membrane antibody technique. Rats were placed on a liquid diet containing either 9.86 (n = 9) or 0 (i = 9) mEq NaCl/daily portion for 2 wk. Labeled antibody was injected and the diets were reversed. After an additional 2 wk period, antibody labeled with a different radionuclide was injected and the animals were sacrificed. Fractional plasma flow distribution was then calculated for each dietary period. No change in flow to any cortical region could be detected. In six additional awake rats on identical dietary regimen, total plasma flow was estimated by the clearance of hippuran-'I. No change in this parameter occurred with changes in NaCl intake. We conclude, therefore, that no change in either total renal plasma flow or intracortical distribution of plasma flow occurs with wide variations in dietary sodium chloride intake in the rat. The implications of this constancy of regional plasma flow are discussed with reference to presumed concomitant alterations in the intrarenal distribution of nephron filtration rate.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Effect of variation in dietary NaCl intake on the intrarenal distribution of plasma flow in the rat

Blantz¹,

Wallin²,

Rector³

et al. 1972

J. Clin. Invest.

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“…Plasma renin concentrations has been found to be inversely cor related with renal vascular resistance and filtration frac tion [8,29], but the effect of ageing both on plasma renin and renal hemodynamics could possibly be the basis for such a relationship. The lack of correlations between RBF and plasma renin activity does not exclude a mu tual interrelationship, since it seems that the common denominator between renin secretion and RBF may be the intrarenal distribution of blood flow rather than total flow [30].…”

Section: Mechanisms Of the Renal Hypoperfusion In Hypertensionmentioning

confidence: 97%

Renal Blood Flow in Man with Essential Hypertension

London¹,

Safar²,

Marchais³

1986

Am J Nephrol

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Abnormalities in renal blood flow in man with sustained essential hypertension are reviewed with emphasis on four points: (1) renal blood flow is decreased not only per unit square meter but also as a fraction of cardiac output, a result which is not observed in other organs, (2) the relationship between cardiac output and renal blood flow is reset, so that restriction of arteriolar renal vessels is dominantly preglomerular in origin, (3) the renal abnormalities may be reversed by α-blockade, suggesting an important contribution of the autonomic nervous system, and, finally, (4) the normal sodium balance in steady-state conditions is achieved through adaptive mechanisms involving the venous system and resulting in decreased venous compliance and increased postglomerular and venous hydrostatic pressures.

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“…The renin-angiotensin-aldosterone system is known to play an important role in the regulation of blood pressure and in sodium homeostasis in the adult animal and human (4,13,19,20,23,31). It also has been implicated in the phenomenon of autoregulation of renal blood flow, single nephron glomerular filtration rate, and intrarenal distribution of blood flow (1,21,22,28).…”

Section: Speculationmentioning

confidence: 99%

The Renin Angiotensin System in Newborn Dogs: Developmental Patterns and Response to Acute Saline Loading

Drukker

Spitzer

et al. 1980

Pediatr Res

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SummaryPlasma renin (PRC) and aldosterone concentrations are known to be high during early postnatal life. Whether this is related to the low rates of renal blood flow or to sodium homeostasis remains unknown. Measurements of PRC, renal Mood flow, and its intrarenal distribution were performed in 1-to Iwk-dd puppies subjected to maneuvers known to stimulate or inhibit renin release. In the awake state, PRC was observed to be higher in t w k d puppies than in older or younger dogs, (P < 0.0001). Signincant differences in PRC were also found between Utters (P < 0.0001), but they did w t account for the age-related changes. Anesthesia resulted in a 3-to 5-fold rise in PRC, whereas saline expansion suppressed PRC at all ages, the fall tending to become progressively greater with age (P < 0.09). There was no significant correlation between the age-related changes in PRC and those in renal blood flow or its intrarenal distribution. The results of these experiments demonstrate that in the newborn from a aualitative poht of view, PRC changes appropriately in response io various stimuli. However, quantitative age-related differences exist in this regard, reflecting an initial immaturity of the feedback system. SpeculationThe lack of correlation between plasma renin concentration and the intrarenal distribution of blood flow, corroborated with the existence of a relationship between plasma renin and the state of the extracellular fluid volume, suggest that during development the renin-Pogiotensin-aldosteme system is geared toward the maintenance of the positive sodium balance intrinsic to the process of growth.The renin-angiotensin-aldosterone system is known to play an important role in the regulation of blood pressure and in sodium homeostasis in the adult animal and human (4,13,19,20,23,31). It also has been implicated in the phenomenon of autoregulation of renal blood flow, single nephron glomerular filtration rate, and intrarenal distribution of blood flow (1,21,22,28). In the newborn period, plasma renin levels are higher by about one order of magnitude than they are later in life (5,9, 11,18). This may relate to the low rates of total renal blood flow (2, 14) and outer cortical blood flow (2) observed at this age. It is known that the rcninangiotensin system can be stimulated in the newborn by peritoneal dialysis or by administration of diuretics (9, 11,29), but there is a relative paucity of information regarding its responsiveness to agents known to suppress it in adults (1 1, 15, 27), and the results of these studies conflict with each other. Another asDect that needs to be investigated is the relationship between the ienin-angiotensin-aldosterone system and sodium homeostasis. The limited natriuretic response of the newborn following volume expansion might be related to the high plasma concentration of aldosterone. In the present study, normal values of immunoassayable plasma renin concentrations (PRC) were established, the developmental pattern was assessed, and the effect of acute volume expansion on PRC was...

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Renal Blood Flow and Renin Activity in Renal Venous Blood in Essential Hypertension

Cited by 41 publications

References 20 publications

Effect of variation in dietary NaCl intake on the intrarenal distribution of plasma flow in the rat

Effect of variation in dietary NaCl intake on the intrarenal distribution of plasma flow in the rat

Renal Blood Flow in Man with Essential Hypertension

The Renin Angiotensin System in Newborn Dogs: Developmental Patterns and Response to Acute Saline Loading

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