Renal cell cancer in the solitary or sole-functioning kidney

Grabstald, Harry; Aviles, Enero

doi:10.1002/1097-0142(196811)22:5<973::aid-cncr2820220512>3.0.co;2-5

Cited by 49 publications

(5 citation statements)

References 35 publications

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“…In reviewing 45 patients with carcinoma in a solitary kidney, Grabstald and Aviles noted that 18% were not situated near either pole. 20 Some authors are skeptical of enucleative surgery in that it conflicts with the postulates of radical removal of a neoplasm. Rosenthal et al and Marshall et al showed in the enucleation of tumors, there were residual tumor cells with the pseudo~apsule.~~~ Graham and Glenn,' Carini et a1., 6 and Novick et al,7 however, have shown survival statistics equivalent to those of most partial nephrectomy series.…”

Section: Morbiditymentioning

confidence: 99%

Enucleation of tumor versus partial nephrectomy as conservative treatment of renal cell carcinoma

Stephens

Graham

1990

Cancer

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In patients with renal insufficiency, solitary kidney, or bilateral renal malignancies, conservative surgery for renal cell carcinoma has been suggested. The authors treated 17 such patients with either enucleation of tumor or partial nephrectomy. Overall survival from disease in this series was 58.8%. Seventy percent of patients undergoing enucleation and 42.9% undergoing partial nephrectomy survived with a mean follow-up period of 5 years. Survival or local recurrence rate after enucleative surgery is an effective treatment of renal carcinoma in selected patients, and despite concerns about tumor invasion of the pseudocapsule, the clinical data do not indicate any difference in survival. There was no significant difference between enucleation of tumor and partial nephrectomy regarding morbidity, mortality, or recurrence rate.

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Section: Morbiditymentioning

confidence: 99%

Enucleation of tumor versus partial nephrectomy as conservative treatment of renal cell carcinoma

Stephens

Graham

1990

Cancer

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“…In 1968, Grabstald and Aviles [11] reported that 23 of 30 patients treated with partial nephrectomy for RCC were free of tumors. In another publication, Schiff et al [12] examined their institutional experience in addition to reviewing the literature.…”

Section: Early Results Of Nephron-sparing Surgerymentioning

confidence: 99%

The evolving role of partial nephrectomy in the management of renal cell carcinoma

Gilbert

Russo²,

Benson³

et al. 2003

Curr Oncol Rep

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The surgical management of renal cell carcinoma has undergone critical review over the past decade. Initially treated with radical nephrectomy, renal cell carcinoma is now approached with nephron-sparing surgical techniques. Improved imaging modalities have substantially increased the number of incidental renal tumors detected, and with the increasing number of incidentally detected kidney tumors, a size and stage migration has occurred in renal cell carcinoma. Early studies showed that disease-free survival rates were similar between cancers treated with radical and partial nephrectomy. The standard now is to offer partial nephrectomy as a surgical option to all patients with renal lesions measuring 4.0 cm or smaller in the setting of a normal contralateral kidney. More recent issues regarding partial nephrectomy concern complication rates and management, renal cell carcinoma multifocality, margin status and distance to normal renal parenchyma, cost analysis, and the development of laparoscopic techniques that duplicate open partial nephrectomy. The purpose of this review is to outline and analyze these more recent concerns regarding partial nephrectomy.

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“…Treatment of a carcinoma in a solitary kidney, especially as in this case, raises problems. The treatment of choice is partial nephrectomy (Grabstald and Aviles, 1968;Parker et al, 1969). Where this is not possible the choice lies between radiotherapy and renal transplantation.…”

Section: Discussionmentioning

confidence: 99%