Renal Cell Carcinoma in Adults 40 Years Old or Less: Young Age is an Independent Prognostic Factor for Cancer-Specific Survival

Taccoen, X.; Valéri, Antoine; Descotes, Jean‐Luc; Morin, Vincent; Stindel, Éric; Doucet, Laurent; Joulin, V.; Bocqueraz, Frédéric; Coulange, C.; Rambeaud, Jean‐Jacques; Fournier, Georges; Méjean, A.

doi:10.1016/j.eururo.2006.10.025

Cited by 87 publications

(95 citation statements)

References 21 publications

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“…Unfortunately, we cannot directly compare the results of our study with those in other cohorts becaused none used similar methodology. Despite the methodological distinctness of our study, we did corroborate the findings of Sánchez-Ortiz and colleagues 3 and of Taccoen and colleagues, 4 namely, that young age exerts a protective effect against RCC-SM. The novelty of our findings resides in the breakpoints that differ from previous studies that used the age of 40 years as a cut-off.…”

Section: Discussionsupporting

confidence: 81%

“…2 Recently, 2 groups of investigators assessed the effect of age on renal cell carcinoma-specific mortality (RCC-SM) in a combined cohort of 4880 patients. [3][4][5] Although these findings are interesting, the cut-offs used to assess the effect of age were not based on specific RCC biology. Instead they were adapted from literature addressing other types of cancer.…”

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confidence: 99%

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Age at diagnosis is a determinant factor of renal cell carcinoma– specific survival in patients treated with nephrectomy

Karakiewicz

Jeldres

Suardi

et al. 2008

CUAJ

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Objective: Based on combined data for 4880 patients, 2 previous studies reported that advanced age is a predictor of increased renal cell carcinoma-specific mortality (RCC-SM). We explored the effect of age in cubic spline analyses to identify the age groups with the most elevated risk for renal cell carcinoma (RCC). Methods:Our study included 3595 patients from 14 European centres who had partial or radical nephrectomies. We used the Kaplan-Meier method to compile life tables, and we performed Cox regression analyses to assess RCC-SM. Covariates included age at diagnosis, sex, TNM (tumour, node, metastasis) stage, tumour size, Fuhrman grade, symptom classification and histological subtype.

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Section: Discussionsupporting

confidence: 81%

mentioning

confidence: 99%

Age at diagnosis is a determinant factor of renal cell carcinoma– specific survival in patients treated with nephrectomy

Karakiewicz

Jeldres

Suardi

et al. 2008

CUAJ

Self Cite

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“…One possible explanation for this condition might be younger patients are generally healthier and are rarely admited for tumor screening [5]. In accordance with the literature [1,3,[5][6][7]10,11], 67.9% of our patients were symptomatic and prevailing symptoms were pain and hematuria. Similarly, Sanchez-Ortiz et al reported 81% incidence of symptomatic tumors in their series [11].…”

Section: Discussionsupporting

confidence: 73%

“…RCCs are rare in young adults and less than 10% of RCCs are seen in this age group [6]. Despite no agreement on the exact age limit in order to consider patients with RCC as young adults.…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathological features and survival rates of patients with renal cell carcinoma under 50 years of age

Atmaca¹,

Bayrak

Kandemir³

et al. 2008

Open Medicine

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AbstractWe analyzed the clinicopathological features and survival rates of the patients with renal cell carcinoma younger than 50 years old. Between 2004 and 2007, 28 patients between 19–49 years underwent surgery for renal cell carcinoma. Presenting symptoms, type of the surgery performed, postoperative outcomes and duration of follow-up were recorded. Mean age was 41.5±7.6 years and 75% of patients were male. The tumor was symptomatic in 19(67.9%) and incidental in 9(32.1%) patients. Radical nephrectomy and nephron-sparing surgery were performed in 18(64.3%) and 10(35.7%) patients, respectively. The most common histologic type was clear cell(67.9%). The mean tumor diameters were 3.5±0.95 and 7.4±5.2 cm in the incidental and symptomatic groups, respectively(p=0.035). Incidentally discovered tumors and tumors treated by NSS did not include Fuhrman grade 4. There were no differences regarding pathological stage and Fuhrman grades when patients were grouped according to their symptomatology(p=0.242 and p=0.265, respectively). Overall mortality was 17.9%(n=5) whereas 4 patients(14.3%) died because of cancer. The mean survival was 30.6 months and cancer specific survival rate was 85.2%. Most of the tumors in this age group were symptomatic and most common histologic subtype was clear cell carcinoma. Incidentally discovered tumors had statistically significant lower tumor size.

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Lymphadenectomy during pulmonary metastasectomy: Impact on survival and recurrence

Londero

Morelli

Parise

et al. 2019

Journal of Surgical Oncology

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Background and Objectives: Lymphadenectomy during pulmonary metastasectomy (PM) is widely carried out. We assessed the potential benefit on patient survival and tumor recurrence of this practice. Methods: One hundred eighty‐one patients undergoing a first PM were studied. Eighty‐six patients (47.5%) underwent lymphadenectomy (L+ group) whereas 95 (52.5%) did not undergo nodal harvesting (L−group). Main outcomes were overall survival (OS) and disease‐free survival (DFS). Median follow‐up was 25 months (interquartile range [IQR], 13‐49). Results: At follow‐up 84 patients (46.4%) died, whereas 97 (53.6%) were still alive with recurrence in 78 patients (43%). There was no difference in 5‐year survival (L+ 30.0% vs L− 43.2%; P = .87) or in the 5‐year cumulative incidence of recurrence (L + 63.2% vs L−80%; P = .07) between the two groups. Multivariable analysis indicated that disease‐free interval (DFI) less than 29 months (P < .001) and lung comorbidities (P = .003) were significant predictors of death. Metastases from non‐small–cell lung cancer increased the risk of lung comorbidities by a factor of 19.8, whereas the risk of DFI less than 29 months was increased nearly 11‐fold. Competing risk regression identified multiple metastases (P = .004), head/neck primary tumor (P = .009), and age less than 67 years (P = .024) as independent risk factors for recurrence. Conclusion: Associated lymphadenectomy showed not to give any additional advantage in terms of survival and recurrence after PM.

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Renal Cell Carcinoma in Adults 40 Years Old or Less: Young Age is an Independent Prognostic Factor for Cancer-Specific Survival

Cited by 87 publications

References 21 publications

Age at diagnosis is a determinant factor of renal cell carcinoma– specific survival in patients treated with nephrectomy

Age at diagnosis is a determinant factor of renal cell carcinoma– specific survival in patients treated with nephrectomy

Clinicopathological features and survival rates of patients with renal cell carcinoma under 50 years of age

Lymphadenectomy during pulmonary metastasectomy: Impact on survival and recurrence

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