Renal cell carcinoma in Ireland: rising mortality and survival

Abstract

The objective of this study was to evaluate the rising trend in the incidence and mortality of renal cell carcinoma in Ireland. Methods: Data from the National Cancer Registry of Ireland on primary adenocarcinomas of the kidney from 2003 to 2013 were evaluated. Statistical analysis was performed on the data using IBM SPSS statistics V24 software package and Microsoft Excel Software. Results: There were 3801 cases of adenocarcinoma of the kidney with 29% of tumours (n=1103) being found incidentally. The age-adjusted incidence rate of renal cell carcinoma in 2003 was 4.66 per 100,000 women and 8.78 per 100,000 men. These figures have risen to 5.78 and 13.14 in 2013, respectively. There was an annual percentage change of +2.2% for women and +4.1% for men from the years 2003 to 2013. For both sexes the age-standardised all-cause mortality rate for renal adenocarcinoma increased from 1.07 per 100,000 in 2003 to 4.32 ± 0.06 per 100,000 in 2013, an annual percentage change of +15%. Age-adjusted mortality rates in the female population in Ireland increased from 0.78 to 2.66, an annual percentage change of +13.1% and from 1.41 to 6.04 in men, an annual percentage change of +15.8%. Conclusion: There is a paradox emerging in Ireland, with both rising survival rates for renal cell carcinoma and rising mortality rates. While the increased incidence of renal cell carcinoma in Ireland can be attributed somewhat to the increased use of various imaging modalities, it may also be attributed to the significant rise in modifiable risk factors as seen in other developed countries, namely hypertension, obesity, and smoking.

Comparing the outcomes of open, laparoscopic and robot‐assisted partial nephrectomy: a network meta‐analysis

“…In recent years, there has been an increase in the incidence of lower-staged RCC, largely secondary to advances in imaging modalities and their improved accessibility [3,4]. Our study aimed to compare the various surgical techniques of NSS: OPN, LPN and RAPN.…”

“…Renal cell carcinoma (RCC) is becoming an increasingly prominent health concern internationally; rates of both incidence and mortality are continuing to rise [1,2]. This is felt to be likely secondary to both increased incidental tumour diagnoses on imaging as well as a rise in modifiable risk factors (hypertension, obesity, smoking) [3].…”

“…Alongside more advanced imaging techniques increased widespread use of CT and MRI has led to a rising number of small and localised RCCs diagnosed [3,4]. For these smaller T1-staged tumours not suitable for active surveillance current European Association of Urology (EAU) guidelines recommend offering patients a partial nephrectomy (PN) [5].…”