Renal Cell Carcinoma in the Allograft: What Is the Role of Polyomavirus

Neirynck, Valerie; Claes, Kathleen; Naesens, Maarten; Wever, Liesbeth De; Pirenne, Jacques; Vanrenterghem, Yves; Poppel, Hendrik Van; Kabanda, André; Lerut, Evelyne

doi:10.1159/000341917

Cited by 22 publications

(22 citation statements)

References 18 publications

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“…Two cases were poorly differentiated RCCs and two were collecting duct carcinomas, one each of a native kidney and a transplanted kidney; additional details on the clinical and pathologic features of these cases are provided in the published reports. [38][39][40][41] In our study, the four kidney cancers in recipients with tBKVN for which we had data were all diagnosed in the native kidney.…”

Section: Discussionmentioning

confidence: 97%

Treatment for presumed BK polyomavirus nephropathy and risk of urinary tract cancers among kidney transplant recipients in the United States

Gupta

Kuppachi

Kalil

et al. 2018

American Journal of Transplantation

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Recent case series describe detection of BK polyomavirus (BKV) in urinary tract cancers in kidney transplant recipients, suggesting that BKV could contribute to the development of these cancers. We assessed risk for urinary tract cancers in kidney recipients with or without treatment for presumed BKV nephropathy (tBKVN) using data from the United States Transplant Cancer Match Study (2003-2013). Among 55 697 included recipients, 2015 (3.6%) were reported with tBKVN. Relative to the general population, incidence was similarly elevated (approximately 4.5-fold) for kidney cancer in recipients with or without tBKVN, and incidence was not increased in either group for prostate cancer. In contrast, for invasive bladder cancer, incidence was more strongly elevated in recipients with versus without tBKVN (standardized incidence ratios 4.5 vs. 1.7; N = 48 cases), corresponding to an incidence rate ratio (IRR) of 2.9 (95% confidence interval [CI] 1.0-8.2), adjusted for sex, age, transplant year, and use of polyclonal antibody induction. As a result, recipients with tBKVN had borderline increased incidence for all urothelial cancers combined (renal pelvis, ureter, and bladder cancers: adjusted IRR 2.2, 95% CI 0.9-5.4; N = 89 cases). Together with reports describing BKV detection in tumor tissues, these results support an association between BKV and urothelial carcinogenesis among kidney transplant recipients.

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Section: Discussionmentioning

confidence: 97%

Treatment for presumed BK polyomavirus nephropathy and risk of urinary tract cancers among kidney transplant recipients in the United States

Gupta

Kuppachi

Kalil

et al. 2018

American Journal of Transplantation

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“…What is more, the BKV DNA was detected in human brain tumors, in neuroblastoma, in urinary tract tumors, in carcinomas of the uterine cervix, vulva, lips and tongue, and in Kaposi's sarcoma. (Tognon et al, 2003;Neirynck et al, 2012;Schowalter et al, 2012;Raeesi et al, 2012;Konietzny et al, 2012). The correlation between BKV and metastatic bladder carcinoma among immunosuppressed transplant recipients, and among BKV and prostate and bladder carcinoma was analyzed.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Polyoma BK Virus (BKPyV) , Epstein-Barr Virus (EBV) and Human Papilloma Virus (HPV) in Oropharyngeal Cancer

Polz-Gruszka¹,

Morshed²,

Jarzynski³

et al. 2015

Pol J Microbiol

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A b s t r a c tThe aim of this study was to analyze the prevalence of BK virus, Human Papillomavirus and Epstein-Barr virus in oropharyngeal cancer, and to test our hypothesis that BKV/HPV/EBV co-infection plays a role in oropharyngeal squamous cell carcinoma. The correlation between viral infection, OSCC, anatomic location, pre-treatment staging, evidence of metastases to lymph nodes, and grading was also investigated. The examination samples were collected from 62 patients from paraffin tissue blocks. Males (90.3%) with, smoking (83.9%) and alcohol abuse (67.7%) problems prevailed in the studied group. G2 histological type was recognized in 80.6% cases. T4 (77.4%) and N2 (56.5%) traits occurred in the majority of patients. No cases of metastasis were observed (M0 100%). HPV -24.2%, EBV -27.4% and BKV 17.7% were detected in the studied samples. We observed co-infection EBV/BKV in 8% of cases, HPV/BKV in 4.8%, and HPV/EBV in 9% cases. Only in two cases co-infection of all three viruses was found.

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“…However, the most serious complication of BKV in these patients is the development of urologic malignancies. Fortunately, such complications are rare and only 36 cases of urothelial carcinoma (UC) (Table ), and several renal cell carcinomas, including collecting duct carcinomas were reported to date …”

Section: Discussionmentioning

confidence: 99%

Unusual BK polyomavirus‐associated urologic malignancies in renal transplant recipients: Report of two cases and review of the literature

Odetola

Isaila

Pambuccian

et al. 2018

Diagnostic Cytopathology

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Renal transplant recipients are at increased risk of developing urologic malignancies, some of which are associated with prolonged BK virus infection. We report two cases of BK virus-associated carcinoma with variant morphological patterns (clear cell adenocarcinoma of the bladder and micropapillary urothelial carcinoma of the pelvicaliceal system) arising in the urinary tract of renal transplant recipients. In both cases, the diagnosis was initially established on cytologic specimens: on urine cytology in one patient and on fine needle aspiration of an inguinal lymph node in the other patient. The unusual cytologic features of both cases (multiple morphologies in one patient and micropapillary pattern in the other), co-occurrence of decoy cells in the urine of one patient and the occurrence of these tumors in renal transplant recipients raised the possibility of BK polyomavirus-associated malignancy and led to confirmatory SV40 immunostains that were positive. These cases expand the morphologic variants of BK virus-associated urologic malignancies diagnosed in solid organ transplant patients. While differentiating BK virus-infected cells from malignant cells in urine cytology specimens is a diagnostic challenge, greater awareness of their possible co-existence is vital, as this could be the only chance for an early diagnosis.

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Renal Cell Carcinoma in the Allograft: What Is the Role of Polyomavirus

Cited by 22 publications

References 18 publications

Treatment for presumed BK polyomavirus nephropathy and risk of urinary tract cancers among kidney transplant recipients in the United States

Treatment for presumed BK polyomavirus nephropathy and risk of urinary tract cancers among kidney transplant recipients in the United States

Prevalence of Polyoma BK Virus (BKPyV) , Epstein-Barr Virus (EBV) and Human Papilloma Virus (HPV) in Oropharyngeal Cancer

Unusual BK polyomavirus‐associated urologic malignancies in renal transplant recipients: Report of two cases and review of the literature

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