Renal Cell Carcinoma is More Aggressive in Turkish Patients with the Metabolic Syndrome

Abstract

Background: Metabolic syndrome (MetS) is a multifactorial disease characterized by impaired glucose tolerance/diabetes, obesity, high triglyceride levels, low HDL levels, and hypertension. In this study we evaluate the relationship between tumor size and grade, and presence of the metabolic syndrome in patients with renal cell carcinoma. Materials and Methods: Between 2007-2013, radical nephrectomy was performed for 310 patients with renal tumors in our clinic and those with pathology reported renal cell carcinoma were enrolled and divided into two groups, with and without metabolic syndrome diagnosed on the basis of the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) criteria. The relationship between tumor size and grade of the two groups (Fuhrman nuclear degree) was evaluated statistically. Results: The metabolic syndrome was found in 70 patients, with a mean age of 65.5 (40-87), as compared to 58.8 (31-84) years in the non-metabolic syndrome group. Tumor size over 7 cm was found in 54% and 33%, respectively, and tumor grade over Fuhrman 3 in 56% and 32% of patients. Patients with metabolic syndrome had significantly higher tumor size and grade (p<0.05). In the presence of hypertension, diabetes and high triglyceride levels, significant assocations were again observed (p<0.05). Tumor size and degree also increased with increasing body mass index but this was not statistically significant (p>0.05). Conclusions: Renal cancer is more aggressive in patients with metabolic syndrome. Lifestyle and risk factors were revealed to be significant influences in renal cancer patients.

Metabolic Syndrome Prevalence in Renal Cell Cancer Patients

“…The MetS (Ozbek et al, 2013) and diabetes mellitus itself have been shown to be associated with aggressive RCC in terms of higher tumor size and nuclear (Fuhrman) grade in recent studies that performed also in Turkish population. Their results point out a possible association between MetS and tumor carsinogenesis, eventhough we did not confirm any link either between MetS and nuclear grade or between MetS and RCC subtype.…”

Changing the Stage, Grade and Histological Subtypes of Renal Cell Carcinomas during 10 Years Period

“…Patients with RCCs are usually older, with the mean age at diagnosis of 60 years (Ozbek et al, 2013). The highest incidence of this disease is found in North America and Europe.…”

“…Higher grade is associated with the biological aggressiveness and increased metastatic potential of the tumour. Most of the RCCs are classified as grade II in the studies (Pichler et al, 2012;Ozbek et al, 2013). The proportion of grade II tumours was between 43 and 61.5%.…”

Risk of Cancer Mortality according to the Metabolic Health Status and Degree of Obesity

“…Notably, cancer is the leading cause of death and is associated with the largest disease burden in Korea Jung et al, 2014). Many studies have suggested that obesity is related to all-cause mortality and cancer mortality (Calle et al, 2013;Flegal et al, 2013;Ozbek et al, 2013). Indeed, the risk of death from cancer increases with body mass index (BMI) (Jee et al, 2006;.…”