Renal cell carcinoma metastases to the pancreas and the thyroid gland 19 years after the primary tumour

Wolf, Sylwia; Obołończyk, Łukasz; Sworczak, Krzysztof; Czapiewski, Piotr; Śledziński, Zbigniew

doi:10.5114/pg.2015.49000

Cited by 7 publications

(39 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1,4,15 Metastasis is either synchronous (25-30%) or metachronous (25-50%), or its initial manifestation. 2,4,5,7,8 Consequently, longterm follow-up for RCC is integral in patient management. 2 Multi-organ metastasis usually indicates poor prognosis, 2 and rarely occurs; for example metachronous RCC reported involving contralateral adrenal gland and urinary bladder, 3 and pancreas and thyroid.…”

Section: Discussionmentioning

confidence: 99%

“…4 Late metastasis many years following radical nephrectomy is well-documented and may cause diagnostic problems. [2][3][4][6][7][8]20 Pancreatic metastasis is uncommon in clinical studies 4.5%; nonetheless, 11% in autopsies. 19 Malignancies are now followed with PET-CT for detection and further evaluation of new lesions as primary versus metastatic.…”

Section: Discussionmentioning

confidence: 99%

“…2,4,5,7,8 Consequently, longterm follow-up for RCC is integral in patient management. 4 Recent US-FNA series cited RCC as the most frequent primary. 8 Completely resected solitary metastasis confers long-term survival with 35-60% 5-year survival.…”

Section: Discussionmentioning

confidence: 99%

“…19 Malignancies are now followed with PET-CT for detection and further evaluation of new lesions as primary versus metastatic. [10][11][12][13][14] Typically metachronous, with latency period 10 years, 4,[9][10][11]13,14 and ranges from 5 months to 29 years 10 with longest reported as 36 years. [2][3][4][6][7][8]20 Pancreatic metastasis is uncommon in clinical studies 4.5%; nonetheless, 11% in autopsies.…”

Section: Discussionmentioning

confidence: 99%

“…3 CCRCC comprises 75% of RCC. 4 Contralateral adrenal metastasis is extremely rare. 4 Contralateral adrenal metastasis is extremely rare.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Cytology diagnosis of metastatic clear cell renal cell carcinoma, synchronous to pancreas, and metachronous to thyroid and contralateral adrenal: Report of a case and literature review

Bokhari

Tiscornia-Wasserman

2016

Diagnostic Cytopathology

View full text Add to dashboard Cite

Renal cell carcinoma metastases to pancreas, thyroid, and contralateral adrenal gland are decidedly uncommon. Clear cell renal cell carcinoma (CCRCC) is the most frequent subtype. Cytology diagnosis may be challenging. A 74-year-old male with remote history of vocal cord malignancy and hypertension presented with abdominal pain. Computed tomography (CT) revealed 8.4 cm left renal mass highly suspicious for renal cell carcinoma, a 1.8 cm mass within vessels near left adrenal and a 2.5 cm mass in pancreatic tail. Right pulmonary middle lobe showed two small nodules. Metastatic CCRCC was diagnosed on preoperative transgastric, endoscopic ultrasound guided fine-needle aspiration cytology of pancreatic tail mass. Left radical nephrectomy and distal pancreatectomy and splenectomy confirmed CCRCC (pT3bNxM1), with metastases in adrenal and pancreatic tail. The 3p deletion identification in pancreatic tumor suggested CCRCC origin. Follow-up positron emission tomography-CT (PET-CT) scan revealed left thyroid lower pole mass. Thyroid ultrasound showed three clustered 6 mm nodules in left mid pole. Ultrasound-guided fine needle aspiration (US-FNA) biopsies, 4-month post-nephrectomy, were consistent with metastatic renal cell carcinoma in lower, and atypia of undetermined significance in mid poles respectively. Left lobectomy and isthmus and pyramidal lobe resections confirmed metastatic renal cell carcinoma. One year post-radical nephrectomy, contralateral adrenal lesion noted on PET-CT was interpreted as metastatic CCRCC on CT-guided core biopsy with touch imprints. Rapid on-site evaluation was implemented, and immunoprofile typical of CCRCC substantiated cytomorphology at all three sites. Previously reported cases of renal cell carcinoma metastases to organs as in the described case are reviewed as well. Diagn. Cytopathol. 2017;45:161-167. © 2016 Wiley Periodicals, Inc.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…3 CCRCC comprises 75% of RCC. 4 Contralateral adrenal metastasis is extremely rare. 4 Contralateral adrenal metastasis is extremely rare.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cytology diagnosis of metastatic clear cell renal cell carcinoma, synchronous to pancreas, and metachronous to thyroid and contralateral adrenal: Report of a case and literature review

Bokhari

Tiscornia-Wasserman

2016

Diagnostic Cytopathology

View full text Add to dashboard Cite

show abstract

The role ofCRPandATG9Bexpression in clear cell renal cell carcinoma

Qi²,

Shan

et al. 2017

Bioscience Reports

View full text Add to dashboard Cite

The purpose of the study is to investigate the correlation between the expression of C-reactive protein (CRP) and autophagy-related 9B (ATG9B) and pathological features of clear cell renal cell carcinoma (CCRCC) patients. We also intended to explore the effects of manipulated expression of CRP and ATG9B on the apoptosis and cell cycle progression of CCRCC cell line. ATG9B expression in CCRCC tissues and adjacent renal tissues was analyzed by immunohistochemistry (IHC). Gene expression was determined at transcription and translational levels using real-time quantitative PCR (RT-qPCR) and Western blot. The association between CRP/ATG9B expression and clinical-pathological parameters including age, gender, pathological grades, TNM stage and distant metastasis of the patients was assessed by correlation analysis. siRNA and overexpression plasmids construction were used to manipulate the expression of CRP in human CCRCC cell line 786-O. Cell apoptosis and cell cycle progression were determined using flow cytometry (FCM) and Hoechst 33258 staining. CRP expression correlates with ATG9B expression. The expression of CRP and ATG9B are significantly correlated with TNM staging, distant metastasis, and survival time of CCRCC patients. A high-level of CRP indicates a poor overall survival (OS). In addition, CRP expression influences cell cycle and apoptosis of CCRCC cells. The study reveals that CRP might be a CCRCC development promoter. In addition, there is a close relationship between CRP and ATG9B in CCRCC carcinogenesis.

show abstract

CT diagnosis for metastasis of clear cell renal cell carcinoma to the pancreas

Yu¹,

Kan

Zhoupeng

et al. 2018

Medicine

View full text Add to dashboard Cite

Rationale:Clear cell renal cell carcinoma (CCRCC) metastasis to pancreas is clinically rare. Misdiagnosis for these cases is frequently due to the low incidence, lack of specific clinical symptoms, and laboratory results.Patient concerns:Three female patients aged 47 years, 69 years, and 76 years, respectively, were admitted to hospital for routine examination after resection of clear cell carcinoma of kidney for 69 months, 57 months, and 123 months, respectively. All 3 cases had no specific clinical symptoms. Routine laboratory tests and common tumor markers including CEA, AFP, CA19-9, and CA125 showed no obvious abnormality.Diagnosis:All 3 cases were finally diagnosed with CCRCC metastasis to pancreas on the basis of CT and pathological findings. On unenhanced CT, foci of the pancreas showed single or multiple nodules or masses with mildly low or equal density and obscure boundary. On enhanced CT, the enhanced mode of foci was similar to CCRCC and showed “fast in fast out.” The main body was confined in the pancreas. The peripheral structure was clear relatively. Obstruction of common bile duct, main pancreatic duct, and local infringement of foci cannot be seen. Additional metastases of right adrenal gland can be seen in one case.Interventions:All 3 cases underwent CT examination and surgical treatment, with complete removal of metastatic tumors.Outcomes:All 3 cases underwent surgical treatment successfully, and recovered successfully after operation.Lessons:The manifestations of pancreatic metastases from CCRCC on CT show certain characteristics, which may be useful to assess the histological features of pancreatic metastases from CCRCC and facilitate the preoperative diagnosis.

show abstract

Renal cell carcinoma metastases to the pancreas and the thyroid gland 19 years after the primary tumour

Cited by 7 publications

References 19 publications

Cytology diagnosis of metastatic clear cell renal cell carcinoma, synchronous to pancreas, and metachronous to thyroid and contralateral adrenal: Report of a case and literature review

Cytology diagnosis of metastatic clear cell renal cell carcinoma, synchronous to pancreas, and metachronous to thyroid and contralateral adrenal: Report of a case and literature review

The role ofCRPandATG9Bexpression in clear cell renal cell carcinoma

CT diagnosis for metastasis of clear cell renal cell carcinoma to the pancreas

Contact Info

Product

Resources

About