Renal cell carcinoma metastases to the skin: a not so rare case?

Kouroupakis, D.; Patsea, Eleni; Sofras, F.; Apostolikas, N.

doi:10.1111/j.1464-410x.1995.tb07411.x

Cited by 37 publications

(30 citation statements)

References 8 publications

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“…In recent times, a few case reports have appeared in the literature describing the rarity of presentation and the need for a high index of suspicion in evaluating a patient presenting with a skin tumor [1][2][3][4][5]]. Recently, Kouroupakis et al [6] have suggested that such patients usually present with synchronous skin metastasis rather than metachronous metastasis. We reviewed our experience with 306 cases of renal cell carcinoma (RCC) treated at our center over the last 12 years in order to determine the incidence and implications of cutaneous metastasis from RCC.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Metastases in Renal Cell Carcinoma

Dorairajan¹,

Hemal²,

Aron³

et al. 1999

Urol Int

100

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Cutaneous metastasis from renal cell carcinoma is believed to be rare. We present our experience with 10 (3.3%) cases seen in the last 12 years among 306 cases of renal adenocarcinoma treated at our center. There were 9 males and 1 female. Age ranged from 30 to 65 years (average 45 years). 5 patients had skin metastases at the time of presentation (stage IV). In one of them the skin nodule, rather than urologic symptoms, was the presenting complaint. 5 patients presented with skin metastasis during follow-up after nephrectomy. The average time to skin metastasis was 51 months for patients in stage I and 13 months in stage IIIb. The scalp was the most common site of metastasis followed by chest and abdomen. 90% of patients had secondaries in at least one other site, most commonly in lungs (4 cases) and bones (5 cases). 4 patients were treated with interferon-α 6 MIU, subcutaneously, three times a week for varying periods from 3 to 4 months but there was no response. In conclusion, cutaneous secondaries from RCC, though uncommon, are not very rare. A few patients may present with a skin mass before detection of the renal tumor. Patients with low-stage disease at presentation may also develop cutaneous secondaries, therefore a prolonged follow-up is required. The commonest site for cutaneous metastasis from RCC is the scalp and face. Most patients had at least one other site of systemic metastasis, hence they were not candidates for curative therapy. Interferon therapy was not helpful. Mean survival after detection of cutaneous metastasis was 7 months.

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Section: Introductionmentioning

confidence: 99%

Cutaneous Metastases in Renal Cell Carcinoma

Dorairajan¹,

Hemal²,

Aron³

et al. 1999

Urol Int

100

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“…When renal cancer has already produced metastases, its prognosis is poor, because it can be cured with neither radiation therapy, nor traditional antineoplastic drugs (chemotherapy), nor hormones. 4,8 Our patient died without undergoing specific treatment for renal tumor.…”

Section: Discussionmentioning

confidence: 91%

“…A small epidermal invagination delimits the lesion from the normal dermis. 8 Some protein antigens are evidenced by use of immunohistochemistry, such as the epithelial membrane antigen (EMA), vimentin, keratin, and carcinoembryonic antigen (CEA). The positive results with vimentin, EMA, and keratin are high-probability indicators of renal cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…The positive results with vimentin, EMA, and keratin are high-probability indicators of renal cell carcinoma. 8 The differential diagnoses of renal lesions are as follows: angiomyolipoma; transitional cell carcinoma of the renal pelvis; adrenal gland tumor; and renal abscess. Regarding the cutaneous lesion, the differential diagnoses are as follows: sebaceous carcinoma; sweat gland tumor; and melanoma.…”

Section: Discussionmentioning

confidence: 99%

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Carcinoma de células renais com metástase cutânea: relato de caso

Paula¹,

Silva²,

Berriel³

2010

J. Bras. Nefrol.

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Renal cell carcinoma or hypernephroma is the third most common neoplasia of the genitourinary tract. Its most common type, representing 60% of the cases, is the clear cell carcinoma, with an incidence peak between 50 and 70 years. Metastases are present at the time of diagnosis in approximately 30% of the patients, the major sites being lungs, bones, skin, liver, and brain. We report the case of a male patient with renal cell carcinoma, whose age, clinical findings, and tumor histological type matched with the most common ones for that pathology. Nevertheless, he already had distant metastasis in an uncommon site at the time of diagnosis. The patient died without undergoing specific treatment for renal cell carcinoma.

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“…Cutaneous metastases from RCC are frequently present in patients with previous history of such malignancy, being exceptional the reported cases in which skin affection was first clinical manifestation [5]. Cutaneous metastases from RCC are usually located in head however that can be found in thorax and upper limbs; most of them are unique described as a rapid growing tumor, red-bluish, lobulated, of well defined edges, ulcerated at times [6].…”

Section: Cutaneous Metastases and Right Hemiplegia As First Manifestamentioning

confidence: 99%

Cutaneous Metastases and Right Hemiplegia as First Manifestations of Renal Cell Carcinoma

Sangines¹

2017

Ann Hematol Oncol

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Renal Cell Carcinoma accounts for 3% of all malignancies, more than half of patients have disseminated disease at diagnosis, such disease characterizes for showing a wide range of clinical presentations, being cutaneous an exceptional example. When skin affection is the only manifestation, it constitutes a major diagnostic challenge. We expose a case of 83 year old patient with multiple cutaneous tumors on head and neck of 4 month evolution, arriving at emergency department for sudden right hemiplegia, in which dermatological approach was crucial for diagnosis.

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Renal cell carcinoma metastases to the skin: a not so rare case?

Abstract: Metastases to the skin from a renal cell carcinoma as first evidence of the disease may not be as rare as the literature describes. Definite proof of the origin of the tumour requires specialized immunohistochemical techniques.

Cited by 37 publications

References 8 publications

Cutaneous Metastases in Renal Cell Carcinoma

Cutaneous Metastases in Renal Cell Carcinoma

Carcinoma de células renais com metástase cutânea: relato de caso

Cutaneous Metastases and Right Hemiplegia as First Manifestations of Renal Cell Carcinoma

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