Renal cell carcinoma metastatic to pancreas

Abbas, Maher A.; Collins, Joe M.; Mulligan, David C.

doi:10.1016/s0002-9610(01)00677-8

Cited by 13 publications

(7 citation statements)

References 4 publications

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“…In fact, half the lymphomas were misdiagnosed as a primary carcinoma. This is attributable to the fact that both lymphomas and renal cell carcinomas often formed solitary masses in the pancreas [1,3,7,8,18,19,24,57,70,71,92], with no obvious evidence of metastasis in other organs. Pancreatic metastases from colorectal carcinomas were also previously noted to mimic primary neoplasms, although this was not the case in our experience.…”

Section: Discussionmentioning

confidence: 99%

“…In a review of 752 renal cell carcinomas over a span of 38 years, it was found that 0.9% developed solitary pancreatic metastasis [65]. In many instances, the interval after the diagnosis to the development of metastasis was several years, sometimes even decades [1,3,4,15,18,21,23,26,28,30,31,34,65,66,71,74,83,86,87,89,93,94,98]. In our patients, the mean interval was 2.6 years; however, in two patients, the metastasis appeared after 5 years.…”

Section: Discussionmentioning

confidence: 99%

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Secondary tumors of the pancreas: an analysis of a surgical and autopsy database and review of the literature

et al. 2004

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The vast majority of pancreatic carcinomas are primary, and, among these, more than 90% are of ductal origin. However, a variety of extrapancreatic tumors may involve the pancreas secondarily and may manifest different clinicopathological characteristics and outcomes. In this study, pathology material from 973 surgical specimens and 4955 adult autopsy cases was reviewed to identify the tumors metastatic to or secondarily involving the pancreas. Biliary and periampullary neoplasms and tumors confined to peripancreatic soft tissue were excluded. In the autopsy series, the pancreas was involved by tumor in 190 cases, and 81 of these were secondary tumors. These were predominantly of epithelial origin, most commonly from lung (34), followed by GI tract (20), kidney (4), breast (3), liver (2), ovary (1), and urinary bladder (1). In addition, there were six tumors of hematopoietic origin, two melanomas, two sarcomas, and two mesotheliomas. Among the 973 surgical specimens, 38 cases contained metastatic tumors to the pancreas. Of these, 11 were lymphomas, and the others were carcinomas of stomach (7), kidney (6), lung (2), liver, prostate, ovary, uterus (1 case of each), and a Merkel cell carcinoma. In addition, there were three malignant gastrointestinal stromal tumors and one retroperitoneal leiomyosarcoma. In conclusion, lung cancer is the most common source of metastasis to pancreas, followed by gastrointestinal carcinomas and lymphomas. These tumors are usually seen in patients with disseminated disease and are detected mainly in autopsies. Secondary tumors constitute about 4% of pancreatic specimens in the authors' surgical database. Approximately one-third of them are clinically mistaken as primary tumors of the pancreas. These are predominantly hematopoietic malignancies or carcinomas of renal or gastric origin. Secondary tumors should be entertained in both the clinical and pathological differential diagnosis of pancreatic neoplasia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Secondary tumors of the pancreas: an analysis of a surgical and autopsy database and review of the literature

et al. 2004

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“…However diagnosis is imperative as long-term survival has been reported after surgical resection, and chemotherapy can be tailored to the diagnosis. 26,27 In our series, both pancreatic metastases could be characterized accurately by EUS-FNA. After the diagnosis, the patient with metastasis from rhabdomyosarcoma underwent debulking surgery followed by chemotherapy, and the patient with me tastasis from lung adenocarcinoma received curative resection.…”

Section: Discussionmentioning

confidence: 54%

Rare pancreatic neoplasms: the utility of endoscopic ultrasound-guided fine-needle aspiration—a large single center study

et al. 2009

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“…[1][2][3] Extension of the tumor into the main pancreatic duct (MPD) and common bile duct (CBD) is rare. Five cases of metastatic renal cell carcinoma in the pancreas with extension into the MPD were also reported, [4][5][6] and one of the tumors extended not only into the MPD but also the CBD. 5 Non-functioning endocrine tumors and a minute mixed ductal-endocrine carcinoma were also reported in intraductal growth of the pancreas.…”

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confidence: 99%

Pancreatic acinar cell carcinoma extending into the common bile and main pancreatic ducts

Yamaguchi

Okabe

Jimi³

et al. 2006

Pathology International

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Acinar cell carcinoma (ACC) of the pancreas is relatively rare, accounting for only approximately 1% of all exocrine pancreatic tumors. A 69-year-old man was found to have a mass lesion measuring approximately 4 cm in diameter in the pancreatic head on ultrasound, abdominal dynamic CT, and percutaneous transhepatic cholangiography. Magnetic resonance cholangiopancreatography showed defect of the lower common bile duct (CBD) due to obstruction by the tumor cast. Histopathologically, the pancreatic head tumor invaded the main pancreatic duct (MPD) and CBD with extension into the CBD in a form of tumor cast. The tumor cells consisted of a solid proliferation with abundant eosinophilic cytoplasm and round nuclei in an acinar and trabecular fashion. A 55-year-old man with upper abdominal pain and nausea, had a cystic lesion approximately 3 cm in size in the pancreatic tail on CT. Histopathologically, the tumor was encapsulated by fibrous capsule and had extensive central necrosis with solid areas in the tumor periphery, and invaded with extension into the MPD in a form of tumor cast. The tumor cells resembled acinar cells in solid growths. Two resected cases of ACC with unusual tumor extension into the CBD and the MPD, respectively, are reported.

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Renal cell carcinoma metastatic to pancreas

Cited by 13 publications

References 4 publications

Secondary tumors of the pancreas: an analysis of a surgical and autopsy database and review of the literature

Secondary tumors of the pancreas: an analysis of a surgical and autopsy database and review of the literature

Rare pancreatic neoplasms: the utility of endoscopic ultrasound-guided fine-needle aspiration—a large single center study

Pancreatic acinar cell carcinoma extending into the common bile and main pancreatic ducts

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