Renal cell carcinoma of native kidney in renal transplant recipients

Moudouni, S.; Lakmichi, A.; Tligui, M.; Rafii, Arach; Tchala, K; Haab, F.; Gattegno, B; Thibault, Philippe; Doublet, Jean‐Dominique

doi:10.1111/j.1464-410x.2006.06267.x

Cited by 57 publications

(53 citation statements)

References 32 publications

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“…Although renal papillary carcinoma comprises 25%-40% of the histologic subtypes seen in transplantation patients ( 6,(23)(24)(25)(26), compared with the 10%-15% of these subtypes seen in the general population ( 6 ), this incidence reached 85% (17 of 20) of the solid tumors in our series. While the cause of this phenomenon is not fully understood, the higher incidence of papillary carcinoma may be due to the prior long-term dialysis that many of these patients have received ( 6 ).…”

Section: Vascular and Interventional Radiology: Outcomes After Ablatimentioning

confidence: 88%

“…For example, in France, from 2000 to 2006, the percentage of donors 50-64 years old and older than 65 years increased from 26% to 35% and from 6.6% to 19%, respectively ( 6 ). Therefore, at present, the real age of a renal transplant (corresponding to donor age) is close to the median age at which RCC is diagnosed in the general population.…”

Section: Patientsmentioning

confidence: 93%

“…The role of immunosuppression in the development of these tumors is still quite controversial ( 34 ): Some studies suggest an increased incidence of tumors in the transplantation population, depending more on the primary renal disease and on the duration of hemodialysis rather than on the degree of immunosuppression ( 6 ). Modifi cation of the immunosuppression regimen for transplant recipients treated for carcinoma is still under debate.…”

Section: Vascular and Interventional Radiology: Outcomes After Ablatimentioning

confidence: 99%

“…Thus, it is desirable, whenever possible, to conserve as much of the transplanted kidney for as long as possible, if small de novo primary renal tumors arise, to maintain quality of life and life expectancy ( 8 ). While surgical nephronsparing and radical nephrectomy have been traditional treatments for these patients ( 6,9 ), percutaneous ablative therapy, which is minimally invasive with lower morbidity and is now considered as a well-established therapeutic approach in the treatment of patients with RCC , should be considered in this group of patients as well ( 6,10 ). As only a few case reports of ablative treatment for carcinomas arising in renal transplants have been published to date ( 3,(10)(11)(12)(13)(14)(15), we sought to pool our experience to retrospectively evaluate the midterm outcome of patients treated for primary RCCs arising in kidney transplants with minimally invasive techniques.…”

Section: Vascular and Interventional Radiology: Outcomes After Ablatimentioning

confidence: 99%

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De Novo Renal Tumors Arising in Kidney Transplants: Midterm Outcome after Percutaneous Thermal Ablation

Cornelis

Buy²,

André³

et al. 2011

Radiology

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Purpose:To retrospectively evaluate the midterm outcome of patients treated for primary renal cell carcinomas arising in kidney transplants with minimally invasive techniques. Materials and Methods:The institutional review board of each participating institution approved this retrospective study and waived informed consent . This study was HIPAA compliant. A request for cases through the European Society of Urogenital Radiology network was made to institutions for patients who fi t the requirements outlined by the authors, and a prospective follow-up of recipients was performed. Twenty-four tumors were identifi ed that developed in the renal allograft of 20 patients from 11 institutions who were treated with radiofrequency ablation ( n = 19) or cryoablation ( n = 5) between 2003 and 2010. Maximal diameter of masses was 6-40 mm (median, 19.5 mm). Twenty masses were solid, and four were type 4 cystic masses. Preablation biopsy was performed for solid tumors only. All images and biologic and biopsy reports were retrospectively reviewed. Significant differences were determined by using a paired t test before and after ablation. Results:Mean follow-up was 27.9 months (range, 7-71 months). Histopathologic examination revealed papillary carcinoma in 17 patients and clear cell carcinoma in three. Tumors were successfully treated with ultrasonographic guidance in six patients, with computed tomographic guidance in 10 patients, and with both in four patients. One case of infection of the tumor site and one case of transitory genitofemoral nerve injury were the only reported complications.No signifi cant change of renal function was noted. Subsequent imaging follow-up did not reveal any case of recurrence in the ablative site. Conclusion:Percutaneous thermal ablation of renal tumors occurring in renal grafts is effective, with low morbidity.q RSNA, 2011

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Section: Vascular and Interventional Radiology: Outcomes After Ablatimentioning

confidence: 88%

Section: Patientsmentioning

confidence: 93%

Section: Vascular and Interventional Radiology: Outcomes After Ablatimentioning

confidence: 99%

Section: Vascular and Interventional Radiology: Outcomes After Ablatimentioning

confidence: 99%

See 2 more Smart Citations

De Novo Renal Tumors Arising in Kidney Transplants: Midterm Outcome after Percutaneous Thermal Ablation

Cornelis

Buy²,

André³

et al. 2011

Radiology

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“…Minimization or withdrawal of Calcineurin inhibitors and replace it with mTOR inhibitor (Sirolimus or Everolimus) is recommended [23]. However, some authors prefer to maintain similar immunosuppressive schemes without modifications, as this will lead to decrease in the rejection risk and hence no clear correlation between immunosuppression and tumours in some reported literatures [26].…”

Section: Treatmentmentioning

confidence: 99%

Case Report: Renal Cell Carcinoma of First Kidney Allograft in Transplanted Recipient for Second Time

Alnour¹,

Alalawi²,

Khalifa³

et al. 2016

UNOAJ

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The uses of immunosuppressive therapy to preserve the new allograft function can significantly increases the incidence of malignancies in transplanted recipients compared with that of general population. The ability to identify and prevent solid organ tumours in the transplant patients, particularly early stages carcinomas depends on regular screening examinations and strict adherence to prophylactic measures. Screening of the patient and donor prior to transplant can help to detect any underlying pre-existing malignancy. Identification of tumor in renal allograft are usually accidental following ultrasonography, CT scan or MRI imaging, so special attention is essential during any imaging examination of renal allograft to detect an early probable tumours.We hereby, present a case record of 51 years old male who had his first kidney transplant in 1987 on the right side from living unrelated donor; he had approached ESRD in 2006 and underwent his second renal transplantation in June 2006 on the left side from living unrelated donor. Though he had stable kidney function, he started to have intermittent haematuria with lump at right lower loin. Allograft sonography had revealed a big mass in the first right transplanted kidney. CT scan with contrast demonstrated a large lobulated enhancing mass arising from the iliac fossa of first transplanted kidney with local, right common iliac vein metastasis and lungs metastasis. Due to above finding patient underwent right allograft nephrectomy.

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Epidemiology, Screening, and Clinical Staging

2013

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Renal cell carcinoma of native kidney in renal transplant recipients

Abstract: There appears to be a greater risk of RCC of the native kidney in patients with end-stage renal disease. The present results suggest that an annual examination of the native kidney before and after renal transplantation is essential.

Cited by 57 publications

References 32 publications

De Novo Renal Tumors Arising in Kidney Transplants: Midterm Outcome after Percutaneous Thermal Ablation

De Novo Renal Tumors Arising in Kidney Transplants: Midterm Outcome after Percutaneous Thermal Ablation

Case Report: Renal Cell Carcinoma of First Kidney Allograft in Transplanted Recipient for Second Time

Epidemiology, Screening, and Clinical Staging

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