Renal Cell Carcinoma: Recognition and Treatment of Synchronous Solitary Contralateral Adrenal Metastasis

Neal, Peter M.; Leach, Gary E.; Kaswick, Jon; Lieber, Michael M.

doi:10.1016/s0022-5347(17)52786-x

Cited by 30 publications

(5 citation statements)

References 9 publications

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“…Table 2 [ 4–22 ] summarizes the patient characteristics, interval between the primary surgery and CAM, and outcome for 56 patients treated surgically for CAM, including the present 11 patients. The age range was 43–82 years (not stated for 12 patients) and there were 33 men and 12 women (not stated for 11).…”

Section: Resultsmentioning

confidence: 99%

Contralateral adrenal metastasis of renal cell carcinoma: treatment, outcome and a review

Lau¹,

Zincke²,

Lohse

et al. 2003

BJU International

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OBJECTIVETo report the surgical treatment of patients with renal cell carcinoma (RCC) metastatic to the contralateral adrenal gland and compare our experience with previous reports, as such metastases are found in 2.5% of patients with metastatic RCC at autopsy, and the role of resecting metastatic RCC at this site is not well defined. PATIENTS AND METHODSWe retrospectively identified 11 patients who had surgery for metastatic RCC to the contralateral adrenal gland between October 1978 and April 2001. The patients' medical records were reviewed for clinical, surgical and pathological features, and the patients' outcome. RESULTSThe mean (median, range) age of the patients at primary nephrectomy was 60.9 (64, 43-79) years; all had clear cell (conventional) RCC. Synchronous contralateral adrenal metastasis occurred in two patients. The mean (median, range) time to contralateral adrenal metastasis after primary nephrectomy for the remaining nine patients was 5.2 (6.1, 0.8-9.2) years. All patients were treated with adrenalectomy; there were no perioperative complications or mortality. Seven patients died from RCC at a mean (median, range) of 3.9 (3.7, 0.2-10) years after adrenalectomy for contralateral adrenal metastasis; one died from other causes at 3.4 years, one from an unknown cause at 1.7 years and two were still alive at the last follow-up. CONCLUSIONSThe surgical resection of contralateral adrenal metastasis from RCC is safe; although most patients died from RCC, survival may be prolonged in individual patients. Hence, in the era of cytoreductive surgery, the removal of solitary contralateral adrenal metastasis seems to be indicated.

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Section: Resultsmentioning

confidence: 99%

Contralateral adrenal metastasis of renal cell carcinoma: treatment, outcome and a review

Lau¹,

Zincke²,

Lohse

et al. 2003

BJU International

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“…The contralateral gland is rarely affected (7,8,16,18,20,22,26,28). Beyond computer assisted tomography and sonography, Wright (1974) and Kahn (1968) have shown that selective angiography is of diagnostic value although this method is no longer considered to be a routine clinical examination (10,17,30).…”

Section: Renal Cell Carcinoma With Contralateral Adrenal Metastasismentioning

confidence: 99%

“…Der Befall der Nebennieren ist seltener. Wir beobachteten 2 Patienten mit Absiedlungen in der kontralateralen Nebenniere, eine Konstellation, die in der Literatur ausgesprochen selten beschrieben wurde (7,8,16,18,20,22,26,28 (7,8,16,18,20,22,26,28). Zur Abklärung hat sich neben der Computertomographie und der Sonographie in Überein-stimmung mit Wright (1974) und Kahn (1968) die selektive Angiographie bewährt, die jedoch im Rahmen der klinischen Routinediagnostik in den Hintergrund getreten ist (10,17,30).…”

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Hypernephroides Nierenzellkarzinom und kontralaterale Nebennierenmetastase

Winter¹,

Villasante²,

Stauffenberg³

1987

Aktuel Urol

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“…Überlebenszeiten z.B. 5, 20, 24 und 36 Monate (12,14,18). Eine bei mehreren Patienten durchgeführte Lymphknotendissektion ergab Metastasenfreiheit (12,14).…”

Section: Introductionunclassified

“…5, 20, 24 und 36 Monate (12,14,18). Eine bei mehreren Patienten durchgeführte Lymphknotendissektion ergab Metastasenfreiheit (12,14). Soweit dies anhand des kleinen in der Literatur beschriebenen Patien-` tengutes ablesbar ist, scheinen zumindest Patienten ohne Lymphknotenmetastasen offensichtlich von der Operation zu profitieren (12,18).…”

Section: Introductionunclassified