Renal cell carcinoma with bilateral ovarian metastasis

Kidney Carcinoma Ovarian Metastasis: Review of the Literature

“…Regarding the presenting symptoms, 11 patients were asymptomatic with metastasis found on scheduled postoperative imaging. Seven patients presented with an abdominal mass [7,8,10,16,22,32], four with weight loss [7,11,13,34], three with vaginal bleeding [10,12,19], two with fever [14,20], two with irregular menses [18,21], two with an abdominal distension [11,26], two with ascites [8,15], abdominal pain [20,36], weight gain [15], fatigue [13], weakness [14], shortness of breath [8,36], pelvic pain [26], generalized malaise and decreased energy [30], flank pain [34], bone fracture [24], and thyroid metastasis [16]. In 26 patients, ovarian metastases were detected three months to 21 years after kidney involvement.…”

“…In difficult cases when ovarian metastasis is the first presentation of the disease, immunohistochemistry can provide diagnostic solutions, and such an approach was followed in 11 of 35 published cases [10-11,21,26-27,31-34,36]. Among the most useful immunohistochemical markers are cluster of differentiation (CD)-10 (Figure 2a) and RCCma (Figure 2b).…”

“…Liang et al mention four patients receiving chemotherapy without providing more details [34]. Systemic adjuvant therapy was used in our case [36] consisting of the administration of sunitinib initially, later changed to sorafenib, which was stopped two months later due to intolerance and toxicity. Subsequently, pazopanib was administered showing a poor response, followed by nivolumab until the patient succumbed to the disease.…”