Renal cell carcinoma with vascular invasion: Mortality and prognostic factors

Rodríguez-Cabello, Miguel Ángel; Laso-García, I.; Donis-Canet, F.; Gómez-Dos-Santos, Victoria; Varona-Crespo, C.; Burgos-Revilla, F.J.

doi:10.1016/j.acuroe.2016.12.008

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…Renal cell carcinoma (RCC) is one of the most common malignant tumor in urinary system with high mortality [ 1 ]. Increased incidence was observed during the last decades [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Reduced E-cadherin facilitates renal cell carcinoma progression by WNT/β-catenin signaling activation

et al. 2017

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Reduced expression of E-cadherin was observed in renal cell carcinoma (RCC). However, its potential clinical value and correlation with WNT/β-catenin signaling in RCC progression was still unclear. Immunohistochemical staining was performed in RCC tissue microarray to examine the expression status and prognosis value of E-cadherin and β-catenin. The potential role of E-cadherin in β-catenin translocation was analyzed with immunobloting assays. A significant negative correlation was observed between E-cadherin and β-catenin expression in RCC tissues. E-cadherin inhibits β-catenin translocation from membrane to cytoplasm in RCC tissues, which was an important step for WNT/β-catenin signaling. Reduced E-cadherin expression was associated with poor prognosis. More importantly, E-cadherin-/β-catenin+ was an independent detrimental factor for survival estimation of RCC patients. Reduced E-cadherin expression in RCC promoted cancer progression via WNT/β-catenin signaling pathway activation. E-cadherin/β-catenin provides a valuable prognosis marker for RCC, which may be an effective target for RCC therapy.

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“…Renal cell carcinoma (RCC) is one of the most common malignant tumor in urinary system with high mortality [ 1 ]. Increased incidence was observed during the last decades [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Reduced E-cadherin facilitates renal cell carcinoma progression by WNT/β-catenin signaling activation

et al. 2017

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Postsurgical complications in patients with renal tumors with venous thrombosis treated with surgery

Caño-Velasco¹,

Herranz-Amo²,

Bernardos³

et al. 2018

Actas Urológicas Españolas (English Edition)

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The Impact of Frailty on Morbidity and Mortality following Open Emergent Colectomies

Congiusta

Palvannan

Merchant

2017

BioMed Research International

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Background Elderly and frail patients undergo open emergency colectomies and are at greater risk for complications. The relationship between frailty and open emergent colectomies is yet unexplored. Objective The purpose of this study was to evaluate the relationship between frailty and outcomes after open emergent colorectal surgery. Design Using the American College of Surgeons National Quality Improvement Program database, a validated modified frailty index was used, along with logistic regression, to assess the relationship between frailty and outcomes. Main Outcome Measures Outcomes included mortality (primary), Clavien-Dindo Complication Grade >3, reintubation, ventilator >48 hours, and reoperation (secondary). Results The rates for 30-day mortality, Clavien-Dindo Grade >3, reintubation, ventilator > 48 hours, and reoperation in our cohort were 16.6%, 36.9%, 8.6%, 23.9%, and 15.0%, respectively. There was a statistically significant increase in prevalence of all outcomes with increasing frailty. Limitations A causal relationship between frailty and complications cannot be established in a retrospective analysis. Also, extrapolation of our data to reflect outcomes beyond 30 days must be done with caution. Conclusions Frailty is a statistically significant predictor of mortality and morbidity after open emergent colectomies and can be used in an acute care setting.

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Renal cell carcinoma with vascular invasion: Mortality and prognostic factors

Cited by 3 publications

References 29 publications

Reduced E-cadherin facilitates renal cell carcinoma progression by WNT/β-catenin signaling activation

Reduced E-cadherin facilitates renal cell carcinoma progression by WNT/β-catenin signaling activation

Postsurgical complications in patients with renal tumors with venous thrombosis treated with surgery

The Impact of Frailty on Morbidity and Mortality following Open Emergent Colectomies

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