Renal cell carcinomas in haemodialysis patients: does haemodialysis duration influence pathological cell types and prognosis?

Sassa, Naoto; Hattori, Ryohei; Tsuzuki, Toyonori; Watarai, Yoshihiko; Fukatsu, Atsushi; Katsuno, Satoshi; Nishikimi, Toshinori; Fujita, Takashi; Ohmae, Kenji; Gotoh, Momokazu

doi:10.1093/ndt/gfq529

Cited by 48 publications

(56 citation statements)

References 19 publications

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“…20,21 In some recent publications, a long duration of dialysis (>10 y) has had a stronger association with ACD-RCC compared with other subtypes of RCC arising in this setting, [22][23][24] although such an association was not identified in another large series. 5,[20][21][22]24,25 Most tumor cells have abundant granular eosinophilic cytoplasm, with round to oval nuclei showing vesicular chromatin and prominent nucleoli. The noncystic tumors are well circumscribed and may be surrounded by a thick fibrous capsule showing dystrophic calcification.…”

Section: Proposed New Epithelial Neoplasms Tubulocystic Renal Cell Camentioning

confidence: 96%

“…20 The tumors often appear as nodules arising from cyst walls, occasionally completely filling these cysts, or as solid masses separate from the cysts. One characteristic feature is the presence of intracellular and/or intercellular microscopic lumina (holes), imparting a cribriform/sieve-like appearance 5,20,22,24,25 (Fig. Cut surfaces are tan to yellow, and hemorrhage and necrotic/friable areas are commonplace.…”

Section: Proposed New Epithelial Neoplasms Tubulocystic Renal Cell Camentioning

confidence: 99%

See 1 more Smart Citation

The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia

Srigley¹,

Delahunt²,

Eble³

et al. 2013

American Journal of Surgical Pathology

946

727

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The classification working group of the International Society of Urological Pathology consensus conference on renal neoplasia was in charge of making recommendations regarding additions and changes to the current World Health Organization Classification of Renal Tumors (2004). Members of the group performed an exhaustive literature review, assessed the results of the preconference survey and participated in the consensus conference discussion and polling activities. On the basis of the above inputs, there was consensus that 5 entities should be recognized as new distinct epithelial tumors within the classification system: tubulocystic renal cell carcinoma (RCC), acquired cystic disease-associated RCC, clear cell (tubulo) papillary RCC, the MiT family translocation RCCs (in particular t(6;11) RCC), and hereditary leiomyomatosis RCC syndrome-associated RCC. In addition, there are 3 rare carcinomas that were considered as emerging or provisional new entities: thyroid-like follicular RCC; succinate dehydrogenase B deficiency-associated RCC; and ALK translocation RCC. Further reports of these entities are required to better understand the nature and behavior of these highly unusual tumors. There were a number of new concepts and suggested modifications to the existing World Health Organization 2004 categories. Within the clear cell RCC group, it was agreed upon that multicystic clear cell RCC is best considered as a neoplasm of low malignant potential. There was agreement that subtyping of papillary RCC is of value and that the oncocytic variant of papillary RCC should not be considered as a distinct entity. The hybrid oncocytic chromophobe tumor, which is an indolent tumor that occurs in 3 settings, namely Birt-Hogg-Dubé Syndrome, renal oncocytosis, and as a sporadic neoplasm, was placed, for the time being, within the chromophobe RCC category. Recent advances related to collecting duct carcinoma, renal medullary carcinoma, and mucinous spindle cell and tubular RCC were elucidated. Outside of the epithelial category, advances in our understanding of angiomyolipoma, including the epithelioid and epithelial cystic variants, were considered. In addition, the apparent relationship between cystic nephroma and mixed epithelial and stromal tumor was discussed, with the consensus that these tumors form a spectrum of neoplasia. Finally, it was thought that the synovial sarcoma should be removed from the mixed epithelial and mesenchymal category and placed within the sarcoma group. The new classification is to be referred to as the International Society of Urological Pathology Vancouver Classification of Renal Neoplasia.

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Section: Proposed New Epithelial Neoplasms Tubulocystic Renal Cell Camentioning

confidence: 96%

Section: Proposed New Epithelial Neoplasms Tubulocystic Renal Cell Camentioning

confidence: 99%

The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia

Srigley¹,

Delahunt²,

Eble³

et al. 2013

American Journal of Surgical Pathology

946

727

View full text Add to dashboard Cite

show abstract

“…[83][84][85][86][87] Duration of dialysis has been associated with ACKD, which is an important risk factor for RCC. [88][89][90][91][92] RCC might also develop in the native kidneys of renal transplant recipients, even in those who have good graft function. 93 than sporadic RCCs.…”

Section: Future Researchmentioning

confidence: 99%

Risk of chronic kidney disease after cancer nephrectomy

Li¹,

Lau²,

Rhee³

et al. 2014

Nat Rev Nephrol

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The incidence of early stage renal cell carcinoma (RCC) is increasing and observational studies have shown equivalent oncological outcomes of partial versus radical nephrectomy for stage I tumours. Population studies suggest that compared with radical nephrectomy, partial nephrectomy is associated with decreased mortality and a lower rate of postoperative decline in kidney function. However, rates of chronic kidney disease (CKD) in patients who have undergone nephrectomy might be higher than in the general population. The risks of new-onset or accelerated CKD and worsened survival after nephrectomy might be linked, as kidney insufficiency is a risk factor for cardiovascular disease and mortality. Nephron-sparing approaches have, therefore, been proposed as the standard of care for patients with type 1a tumours and as a viable option for those with type 1b tumours. However, prospective data on the incidence of de novo and accelerated CKD after cancer nephrectomy is lacking, and the only randomized trial to date was closed prematurely. Intrinsic abnormalities in non-neoplastic kidney parenchyma and comorbid conditions (including diabetes mellitus and hypertension) might increase the risks of CKD and RCC. More research is needed to better understand the risk of CKD post-nephrectomy, to develop and validate predictive scores for risk-stratification, and to optimize patient management.

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“…The choice of RRT or dialysis duration might modify the risk of cancer [9], [10]. Patients undergoing hemodialysis (HD) longer than ten years have greatly increased risk of developing RCC with a sarcomatoid component than those with shorter than ten years [11]. Moreover, the different histologic spectrum of RCC occurs according to the duration of dialysis [12].…”

Section: Introductionmentioning

confidence: 99%

Sex Differences in the Development of Malignancies among End-Stage Renal Disease Patients: A Nationwide Population-Based Follow-Up Study in Taiwan

et al. 2012

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Increasing evidence indicates that end-stage renal disease (ESRD) is associated with the morbidity of cancer. However, whether different dialysis modality and sex effect modify the cancer risks in ESRD patients remains unclear. A total of 3,570 newly diagnosed ESRD patients and 14,280 controls matched for age, sex, index month, and index year were recruited from the National Health Insurance Research Database in Taiwan. The ESRD status was ascertained from the registry of catastrophic illness patients. The incidence of cancer was identified through cross-referencing with the National Cancer Registry System. The Cox proportional hazards model and the Kaplan–Meier method were used for analyses. A similar twofold increase in cancer risk was observed among ESRD patients undergoing hemodialysis (HD) or peritoneal dialysis (PD) after adjusting for other potential risk factors. Patients with the highest cancer risk, approximately fourfold increased risk, were those received renal transplants. Urothelial carcinoma (UC) had the highest incidence in HD and PD patients. However, renal cell carcinoma (RCC) had the highest incidence in the renal transplantation (RT) group. In addition, female patients undergoing RT or PD had a higher incidence of RCC and UC, respectively. Male patients under HD had both higher incidence of RCC and UC. In conclusion, different dialysis modality could modify the cancer risks in ESRD patients. We also found sex effect on genitourinary malignancy when they are under different dialysis modality.

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Renal cell carcinomas in haemodialysis patients: does haemodialysis duration influence pathological cell types and prognosis?

Cited by 48 publications

References 19 publications

The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia

The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia

Risk of chronic kidney disease after cancer nephrectomy

Sex Differences in the Development of Malignancies among End-Stage Renal Disease Patients: A Nationwide Population-Based Follow-Up Study in Taiwan

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